After its game against Ohio State, Rutgers returned home to face Michigan in Michigan's first road game of the season. Michigan defeated Rutgers 49–16 in the previous meeting.
Michigan won in a historic blowout, 78–0. Michigan opened the scoring in the first quarter via a four-yard touchdown run from Ty Isaac. Michigan added to its lead via a 30-yard touchdown pass from Speight to Chesson. Michigan added 29 points in the second quarter via a seven-yard touchdown run from Peppers, two one-yard touchdown runs from Hill, a two-point conversion Garrett Moores rush, and a four-yard touchdown run from Peppers, which made the score 43–0 in favor of Michigan at half-time. Michigan added 14 points in the third quarter via an 11-yard touchdown pass from John O'Korn to Hill, and a 15-yard touchdown run from Karan Higdon. Michigan added 21 points in the fourth quarter via a 13-yard touchdown run from Bobby Henderson, a 44-yard touchdown run from Higdon, and a 34-yard touchdown run from Isaac.
The game was a statistical domination for Michigan. Michigan accumulated 600 yards of offense and eleven touchdowns (nine rushing, two passing); the nine rushing touchdowns tied for the most in modern program history. Khalid Hill recorded three touchdown scores, making him the first Michigan player with three or more scores since Chesson had four in 2015 against Indiana. Michigan improved to 6–0 for the first time since 2011 and recorded its first shutout since the previous season against Northwestern. Michigan's defense held Rutgers to only 39 total yards, two first downs, 14 three-and-outs and 0-for-17 on third down. Michigan recorded its largest margin of victory—during either conference or non-conference play—since it defeated Chicago 85–0 in 1939. This was also the largest margin of victory in any Big Ten game since the same Michigan victory over Chicago. The defeat was Rutgers' worst loss since an 82–0 loss to Princeton in 1888.
^Note: Claims that Michigan's nine touchdowns are a program record ignore the accomplishments of Fielding H. Yost's "Point-a-Minute" teams that scored more than nine touchdowns on multiple occasions. Michigan's single-game record is actually 22 touchdowns, a feat accomplished twice – on October 26, 1901, against University of Buffalo and on October 24, 1904, against West Virginia. These games occurred before the forward pass was legalized in 1906; therefore, all points scored would have been via rushing touchdowns.