David Martin and Rajeev Ram were the defending champions.
Ram chose not to participate, Martin partnered up with Lester Cook, but they lost to Andrew Anderson and Fritz Wolmarans in the semifinals.
South African players won this tournament. They defeated qualifiers Brett Joelson and Chris Klingemann 6–2, 6–3 in the final.
| Doubles | |
|---|---|
| 2010 USTA Challenger of Oklahoma | |
| Champions |  Andrew Anderson Fritz Wolmarans |
| Runners-up |  Brett Joelson  Chris Klingemann |
| Score | 6–2, 6–3 |
Seeds edit
Lester Cook / David Martin (semifinals)
Pierre-Ludovic Duclos / Vasek Pospisil (semifinals)
Nikolaus Moser / 
Artem Sitak (quarterfinals)- Alex Kuznetsov / Jesse Witten (first round)
Draw edit
Key edit
- Q = Qualifier
- WC = Wild card
- LL = Lucky loser
- Alt = Alternate
- SE = Special exempt
- PR = Protected ranking
- ITF = ITF entry
- JE = Junior exempt
- w/o = Walkover
- r = Retired
- d = Defaulted
- SR = Special ranking
Draw edit
| First round | Quarterfinals | Semifinals | Finals | ||||||||||||||||||||||||
| 1 | L Cook D Martin
| 7 | 6 | ||||||||||||||||||||||||
K Kim D Yoo
| 5 | 0 | 1 | L Cook D Martin
| 7 | 62 | [10] | ||||||||||||||||||||
Ashwin Kumar F Martin
| Ashwin Kumar F Martin
| 5 | 7 | [6] | |||||||||||||||||||||||
| J Levine Greg Ouellette
| w/o | 1 | L Cook D Martin
| 7 | 3 | [8] | |||||||||||||||||||||
| 3 |  N Moser A Sitak
| 7 | 6 | A Anderson F Wolmarans
| 5 | 6 | [10] | ||||||||||||||||||||
| J Cox D Young
| 65 | 4 | 3 | N Moser A Sitak
| 4 | 1 | |||||||||||||||||||||
| A Anderson F Wolmarans
| 6 | 7 | A Anderson F Wolmarans
| 6 | 6 | ||||||||||||||||||||||
| B Reynolds T Smyczek
| 1 | 61 | A Anderson F Wolmarans
| 6 | 6 | ||||||||||||||||||||||
E Nunez A Sadecky
| 6 | 7 | Q | B Joelson C Klingemann
| 2 | 3 | |||||||||||||||||||||
| WC |  R Biktyakov O Nedovyesov
| 2 | 64 | E Nunez A Sadecky
| w/o | ||||||||||||||||||||||
| Q | Brett Joelson Chris Klingemann
| 6 | 7 | Q | B Joelson C Klingemann
| ||||||||||||||||||||||
| 4 | A Kuznetsov J Witten
| 4 | 5 | Q | B Joelson C Klingemann
| 2 | 7 | [10] | |||||||||||||||||||
| WC |  M Arévalo Ashley Watling
| 0 | 6 | [10] | 2 | P-L Duclos V Pospisil
| 6 | 65 | [3] | ||||||||||||||||||
| B Evans P Simmonds
| 6 | 4 | [7] | WC | M Arévalo A Watling
| 4 | 4 | ||||||||||||||||||||
| WC |  A Dăescu Will Gray
| 3 | 2 | 2 | P-L Duclos V Pospisil
| 6 | 6 | ||||||||||||||||||||
| 2 | P-L Duclos V Pospisil
| 6 | 6 | ||||||||||||||||||||||||