2,3-dihydroxybenzoate 3,4-dioxygenase

In enzymology, a 2,3-dihydroxybenzoate 3,4-dioxygenase (EC 1.13.11.14) is an enzyme that catalyzes the chemical reaction

2,3-dihydroxybenzoate 3,4-dioxygenase
Identifiers
EC no.1.13.11.14
CAS no.9032-31-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins
2,3-dihydroxybenzoate + O2 3-carboxy-2-hydroxymuconate semialdehyde

Thus, the two substrates of this enzyme are 2,3-dihydroxybenzoate and O2, whereas its product is 3-carboxy-2-hydroxymuconate semialdehyde.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is 2,3-dihydroxybenzoate:oxygen 3,4-oxidoreductase (decyclizing). Other names in common use include o-pyrocatechuate oxygenase, 2,3-dihydroxybenzoate 1,2-dioxygenase, 2,3-dihydroxybenzoic oxygenase, and 2,3-dihydroxybenzoate oxygenase. This enzyme participates in benzoate degradation via hydroxylation.

References

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  • Ribbons DW (1966). "Bacterial oxidation of 2,3-dihydroxybenzoic acid - a new oxygenase". Biochem. J. 99: 30.