Zinc finger protein 536

Zinc finger protein 536 is a protein that in humans is encoded by the ZNF536 gene.

ZNF536
Identifiers
Aliases	ZNF536, zinc finger protein 536
External IDs	OMIM: 618037; MGI: 1926102; HomoloGene: 8813; GeneCards: ZNF536; OMA:ZNF536 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q12 Start 30,228,290 bp End 30,713,538 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 B2-B3 Start 37,318,024 bp End 37,773,641 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell retinal pigment epithelium corpus callosum inferior ganglion of vagus nerve cerebellar vermis sural nerve pons medulla oblongata C1 segment Brodmann area 46 Top expressed in epithelium of lens neural layer of retina retinal pigment epithelium sciatic nerve ciliary body lumbar subsegment of spinal cord ventricular zone Rostral migratory stream iris pelvic ganglion More reference expression data BioGPS n/a
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific retinoic acid-responsive element binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process negative regulation of retinoic acid receptor signaling pathway multicellular organism development regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II negative regulation of neuron differentiation signal transduction transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9745 243937 Ensembl ENSG00000198597 ENSMUSG00000043456 UniProt O15090 Q8K083 RefSeq (mRNA) NM_014717 NM_001352260 NM_001376110 NM_001376111 NM_172385 RefSeq (protein) NP_055532 NP_001339189 NP_001363039 NP_001363040 NP_759017 NP_001391020 NP_001391022 NP_001391023 NP_001391024 NP_001391025 NP_001391026 NP_001391028 NP_001391029 Location (UCSC) Chr 19: 30.23 – 30.71 Mb Chr 7: 37.32 – 37.77 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Qin Z, Ren F, Xu X, Ren Y, Li H, Wang Y, Zhai Y, Chang Z (July 2009). "ZNF536, a novel zinc finger protein specifically expressed in the brain, negatively regulates neuron differentiation by repressing retinoic acid-induced gene transcription". Molecular and Cellular Biology. 29 (13): 3633–43. doi:10.1128/MCB.00362-09. PMC 2698762. PMID 19398580.
• Dugas JC, Tai YC, Speed TP, Ngai J, Barres BA (October 2006). "Functional genomic analysis of oligodendrocyte differentiation". The Journal of Neuroscience. 26 (43): 10967–83. doi:10.1523/JNEUROSCI.2572-06.2006. PMC 6674672. PMID 17065439.
• Benjamin EJ, Dupuis J, Larson MG, Lunetta KL, Booth SL, Govindaraju DR, Kathiresan S, Keaney JF, Keyes MJ, Lin JP, Meigs JB, Robins SJ, Rong J, Schnabel R, Vita JA, Wang TJ, Wilson PW, Wolf PA, Vasan RS (September 2007). "Genome-wide association with select biomarker traits in the Framingham Heart Study". BMC Medical Genetics. 8 (Suppl 1): S11. doi:10.1186/1471-2350-8-S1-S11. PMC 1995615. PMID 17903293.
• Low SK, Chung S, Takahashi A, Zembutsu H, Mushiroda T, Kubo M, Nakamura Y (August 2013). "Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan". Cancer Science. 104 (8): 1074–82. doi:10.1111/cas.12186. PMC 7657179. PMID 23648065. S2CID 5954226.
• Meng W, Butterworth J, Bradley DT, Hughes AE, Soler V, Calvas P, Malecaze F (December 2012). "A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population". Investigative Ophthalmology & Visual Science. 53 (13): 7983–8. doi:10.1167/iovs.12-10409. PMID 23049088.
• Sakai T, Hino K, Wada S, Maeda H (August 2003). "Identification of the DNA binding specificity of the human ZNF219 protein and its function as a transcriptional repressor". DNA Research. 10 (4): 155–65. doi:10.1093/dnares/10.4.155. PMID 14621294.
• Seppälä I, Kleber ME, Lyytikäinen LP, Hernesniemi JA, Mäkelä KM, Oksala N, Laaksonen R, Pilz S, Tomaschitz A, Silbernagel G, Boehm BO, Grammer TB, Koskinen T, Juonala M, Hutri-Kähönen N, Alfthan G, Viikari JS, Kähonen M, Raitakari OT, März W, Meinitzer A, Lehtimäki T (February 2014). "Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality". European Heart Journal. 35 (8): 524–31. doi:10.1093/eurheartj/eht447. PMID 24159190.