Zinc finger protein 266

Zinc finger protein 266 is a protein that in humans is encoded by the ZNF266 gene.

ZNF266
Identifiers
Aliases	ZNF266, HZF1, zinc finger protein 266
External IDs	OMIM: 604751 MGI: 1924769 HomoloGene: 105676 GeneCards: ZNF266
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.2 Start 9,412,461 bp End 9,435,571 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A3 Start 20,406,364 bp End 20,432,713 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in visceral pleura tibia spleen parietal pleura gastric mucosa superficial temporal artery trabecular bone hair follicle corpus epididymis cardia Top expressed in hand otolith organ utricle primitive streak medial ganglionic eminence epidermis hair follicle left lung lobe maxillary prominence external carotid artery More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component intracellular anatomical structure nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10781 77519 Ensembl ENSG00000174652 ENSMUSG00000060510 UniProt Q14584 n/a RefSeq (mRNA) NM_001271314 NM_006631 NM_198058 NM_001082485 NM_001135019 RefSeq (protein) NP_001258243 NP_006622 NP_001357303 NP_001357304 NP_001357305 NP_001357306 NP_001357307 NP_001357308 NP_001357309 NP_001357310 NP_001357311 NP_001357312 NP_001357313 NP_001357314 NP_001357315 NP_001357316 NP_001357317 NP_001357318 NP_001357319 NP_001357320 NP_001357321 NP_001357322 NP_001357323 NP_001357324 NP_001357325 NP_001357326 NP_001357327 NP_001357328 NP_001357329 n/a Location (UCSC) Chr 19: 9.41 – 9.44 Mb Chr 9: 20.41 – 20.43 Mb PubMed search
Wikidata
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Function

This gene encodes a protein containing many tandem zinc-finger motifs. Zinc fingers are protein or nucleic acid-binding domains, and may be involved in a variety of functions, including regulation of transcription. This gene is located in a cluster of similar genes encoding zinc finger proteins on chromosome 19. Alternative splicing results in multiple transcript variants for this gene.

Further reading

• Liu X, Jin EZ, Zhi JX, Li XQ (2011). "Identification of HZF1 as a novel target gene of the MEF2 transcription factor". Molecular Medicine Reports. 4 (3): 465–9. doi:10.3892/mmr.2011.465. PMID 21468593.
• Abrink M, Aveskogh M, Hellman L (Feb 1995). "Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937". DNA and Cell Biology. 14 (2): 125–36. doi:10.1089/dna.1995.14.125. PMID 7865130.
• Peng H, Du ZW, Zhang JW (Jun 2006). "Identification and characterization of a novel zinc finger protein (HZF1) gene and its function in erythroid and megakaryocytic differentiation of K562 cells". Leukemia. 20 (6): 1109–16. doi:10.1038/sj.leu.2404212. PMID 16628192.
• Li XB, Chen J, Deng MJ, Wang F, Du ZW, Zhang JW (2011). "Zinc finger protein HZF1 promotes K562 cell proliferation by interacting with and inhibiting INCA1". Molecular Medicine Reports. 4 (6): 1131–7. doi:10.3892/mmr.2011.564. PMID 21874239.
• Deng MJ, Li XB, Peng H, Zhang JW (Feb 2010). "Identification of the trans-activation domain and the nuclear location signals of human zinc finger protein HZF1 (ZNF16)". Molecular Biotechnology. 44 (2): 83–9. doi:10.1007/s12033-009-9210-8. PMID 19763908. S2CID 3470718.
• Gamsjaeger R, Liew CK, Loughlin FE, Crossley M, Mackay JP (Feb 2007). "Sticky fingers: zinc-fingers as protein-recognition motifs". Trends in Biochemical Sciences. 32 (2): 63–70. doi:10.1016/j.tibs.2006.12.007. PMID 17210253.
• Fransen K, Visschedijk MC, van Sommeren S, Fu JY, Franke L, Festen EA, Stokkers PC, van Bodegraven AA, Crusius JB, Hommes DW, Zanen P, de Jong DJ, Wijmenga C, van Diemen CC, Weersma RK (Sep 2010). "Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease". Human Molecular Genetics. 19 (17): 3482–8. doi:10.1093/hmg/ddq264. PMID 20601676.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.