Zangpo (Wylie: bzang po, ZYPY: བཟང་པོ་) is a surname. Notable people with the surname include:
- Rinchen Zangpo (958–1055), principal translator of Sanskrit Buddhist texts into Tibetan
- Rongzom Chokyi Zangpo, scholar of the Nyingma school of Tibetan Buddhism
- Takna Jigme Zangpo (1926–2020), Chinese political prisoner