ZNRF1

E3 ubiquitin-protein ligase ZNRF1 is an enzyme that in humans is encoded by the ZNRF1 gene.

ZNRF1
Identifiers
Aliases	ZNRF1, NIN283, zinc and ring finger 1, E3 ubiquitin protein ligase, zinc and ring finger 1
External IDs	OMIM: 612060; MGI: 2177308; HomoloGene: 41858; GeneCards: ZNRF1; OMA:ZNRF1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16q23.1 Start 74,999,024 bp End 75,110,994 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 E1 Start 112,262,729 bp End 112,352,662 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus mucosa of pharynx body of tongue secondary oocyte gingival epithelium pancreatic ductal cell quadriceps femoris muscle vastus lateralis muscle Skeletal muscle tissue of rectus abdominis muscle of thigh Top expressed in granulocyte thymus superior surface of tongue gallbladder superior frontal gyrus neural layer of retina primary visual cortex dentate gyrus of hippocampal formation granule cell muscle of thigh lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin protein ligase activity metal ion binding ubiquitin-protein transferase activity transferase activity Cellular component endosome cell junction lysosome synapse synaptic vesicle membrane membrane cytoplasmic vesicle cytosol Biological process protein K48-linked ubiquitination protein ubiquitination protein polyubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84937 170737 Ensembl ENSG00000186187 ENSMUSG00000033545 UniProt Q8ND25 Q91V17 RefSeq (mRNA) NM_032268 NM_001168621 NM_001168622 NM_001168623 NM_133206 NM_001363488 NM_001363489 RefSeq (protein) NP_115644 NP_001162092 NP_001162093 NP_001162094 NP_573469 NP_001350417 NP_001350418 Location (UCSC) Chr 16: 75 – 75.11 Mb Chr 8: 112.26 – 112.35 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

In a study identifying genes in rat that are upregulated in response to nerve damage, a gene which is highly expressed in ganglia and in the central nervous system was found. The protein encoded by the rat gene contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification. The protein encoded by this human gene is highly similar in sequence to that encoded by the rat gene.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Araki T, Nagarajan R, Milbrandt J (2001). "Identification of genes induced in peripheral nerve after injury. Expression profiling and novel gene discovery". J. Biol. Chem. 276 (36): 34131–41. doi:10.1074/jbc.M104271200. PMID 11427537.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Araki T, Milbrandt J (2003). "ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases". J. Neurosci. 23 (28): 9385–94. doi:10.1523/JNEUROSCI.23-28-09385.2003. PMC 6740566. PMID 14561866.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.