E3 ubiquitin-protein ligase ZNRF1 is an enzyme that in humans is encoded by the ZNRF1 gene.[5]

ZNRF1
Identifiers
AliasesZNRF1, NIN283, zinc and ring finger 1, E3 ubiquitin protein ligase, zinc and ring finger 1
External IDsOMIM: 612060; MGI: 2177308; HomoloGene: 41858; GeneCards: ZNRF1; OMA:ZNRF1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032268

RefSeq (protein)

NP_115644

Location (UCSC)Chr 16: 75 – 75.11 MbChr 8: 112.26 – 112.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

In a study identifying genes in rat that are upregulated in response to nerve damage, a gene which is highly expressed in ganglia and in the central nervous system was found. The protein encoded by the rat gene contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification. The protein encoded by this human gene is highly similar in sequence to that encoded by the rat gene.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186187Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033545Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: ZNRF1 zinc and ring finger 1".

Further reading

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