ZNF224

Zinc finger protein 224 is a protein that in humans is encoded by the ZNF224 gene.

ZNF224
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2ELY, 2ELZ, 2EM0, 2EM6, 2EM7, 2EM8, 2EM9, 2EN1, 2EN8, 2ENA, 2ENC, 2EOQ, 2EOR, 2EQ4, 2YSP, 2YTH
Identifiers
Aliases	ZNF224, BMZF-2, BMZF2, KOX22, ZNF255, ZNF27, ZNF233, zinc finger protein 224
External IDs	OMIM: 194555 HomoloGene: 130663 GeneCards: ZNF224
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.31 Start 44,094,361 bp End 44,109,886 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere rectum gastric mucosa right uterine tube spleen left lobe of thyroid gland right lobe of thyroid gland right lung lymph node sural nerve n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nucleic acid binding DNA-binding transcription factor activity metal ion binding DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus intracellular anatomical structure nuclear membrane transcription repressor complex Biological process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7767 n/a Ensembl ENSG00000267680 n/a UniProt Q9NZL3 n/a RefSeq (mRNA) NM_013398 NM_001321645 n/a RefSeq (protein) NP_001308574 NP_037530 n/a Location (UCSC) Chr 19: 44.09 – 44.11 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Further reading

• Medugno L, Florio F, Cesaro E, et al. (2007). "Differential expression and cellular localization of ZNF224 and ZNF255, two isoforms of the Krüppel-like zinc-finger protein family". Gene. 403 (1–2): 125–131. doi:10.1016/j.gene.2007.07.036. PMID 17900823.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Shannon M, Hamilton AT, Gordon L, et al. (2003). "Differential Expansion of Zinc-Finger Transcription Factor Loci in Homologous Human and Mouse Gene Clusters". Genome Res. 13 (6A): 1097–1110. doi:10.1101/gr.963903. PMC 403638. PMID 12743021.
• Medugno L, Costanzo P, Lupo A, et al. (2004). "A novel zinc finger transcriptional repressor, ZNF224, interacts with the negative regulatory element (AldA-NRE) and inhibits gene expression". FEBS Lett. 534 (1–3): 93–100. doi:10.1016/S0014-5793(02)03783-3. PMID 12527367. S2CID 3087490.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lee TH, Lwu S, Kim J, Pelletier J (2003). "Inhibition of Wilms tumor 1 transactivation by bone marrow zinc finger 2, a novel transcriptional repressor". J. Biol. Chem. 277 (47): 44826–44837. doi:10.1074/jbc.M205667200. PMID 12239212.
• Han ZG, Zhang QH, Ye M, et al. (2000). "Molecular cloning of six novel Krüppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB". J. Biol. Chem. 274 (50): 35741–35748. doi:10.1074/jbc.274.50.35741. PMID 10585455.
• Thiesen HJ (1991). "Multiple genes encoding zinc finger domains are expressed in human T cells". New Biol. 2 (4): 363–374. PMID 2288909.