Zinc finger protein 57 homolog (ZFP57), also known as zinc finger protein 698 (ZNF698), is a protein that in humans is encoded by the ZFP57 gene.[5]

ZFP57
Identifiers
AliasesZFP57, C6orf40, TNDM1, ZNF698, bA145L22, bA145L22.2, ZFP57 zinc finger protein
External IDsOMIM: 612192 MGI: 99204 HomoloGene: 7603 GeneCards: ZFP57
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for ZFP57
Genomic location for ZFP57
Band6p22.1Start29,672,392 bp[1]
End29,681,110 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001109809
NM_001366333

NM_001013745
NM_001168501
NM_001168502
NM_009559

RefSeq (protein)

NP_001103279
NP_001353262
NP_001103279.2

NP_001013767
NP_001161973
NP_001161974

Location (UCSC)Chr 6: 29.67 – 29.68 MbChr 17: 37 – 37.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FunctionEdit

The protein encoded by this gene is a zinc finger protein containing a KRAB domain. Studies in mouse suggest that this protein may function as a transcriptional repressor.[5]

Clinical significanceEdit

Mutations in the ZFP57 gene may be associated with transient neonatal diabetes mellitus.[6]

ReferencesEdit

  1. ^ a b c ENSG00000204644, ENSG00000223858, ENSG00000206510, ENSG00000223852, ENSG00000227858, ENSG00000232099, ENSG00000234669 GRCh38: Ensembl release 89: ENSG00000226858, ENSG00000204644, ENSG00000223858, ENSG00000206510, ENSG00000223852, ENSG00000227858, ENSG00000232099, ENSG00000234669 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036036 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: zinc finger protein 57 homolog (mouse)".
  6. ^ Mackay DJ, Callaway JL, Marks SM, et al. (August 2008). "Hypomethylation of multiple imprinted loci in individuals with transient neonatal diabetes is associated with mutations in ZFP57". Nat. Genet. 40 (8): 949–51. doi:10.1038/ng.187. PMID 18622393.

Further readingEdit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.