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YY1 (Yin Yang 1)[5] is a transcriptional repressor protein in humans that is encoded by the YY1 gene.[6][7]

YY1
Protein YY1 PDB 1ubd.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesYY1, DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1, YY1 transcription factor, GADEVS
External IDsMGI: 99150 HomoloGene: 2556 GeneCards: YY1
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for YY1
Genomic location for YY1
Band14q32.2Start100,238,298 bp[1]
End100,282,792 bp[1]
RNA expression pattern
PBB GE YY1 201902 s at fs.png

PBB GE YY1 201901 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003403

NM_009537

RefSeq (protein)

NP_003394

NP_033563

Location (UCSC)Chr 14: 100.24 – 100.28 MbChr 12: 108.79 – 108.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Contents

FunctionEdit

YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. Hence, the YY in the name stands for "yin-yang." YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.[8] YY1 promotes enhancer-promoter chromatin loops by forming dimers and promoting DNA interactions. Its disregulation disrupts enhancer-promoter loops and gene expression.[9][10]

Clinical significanceEdit

YY1 heterozygous deletions, missense, and nonsense mutations cause Gabriele-DeVries syndrome (GADEVS) [11] [12], an autosomal dominant neurodevelopmental disorder characterized by intellectual disability, dysmorphic facial features, feeding problems, intrauterine growth restriction, variable cognitive impairment, behavioral problems and other congenital malformations.[10] It is available a website to share and collect clinical information between clinical doctors and families of mutated individuals.[13]



InteractionsEdit

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100811 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021264 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Thiaville MM, Kim J (2011). "Oncogenic potential of yin yang 1 mediated through control of imprinted genes". Critical Reviews in Oncogenesis. 16 (3–4): 199–209. doi:10.1615/critrevoncog.v16.i3-4.40. PMC 3392609. PMID 22248054.
  6. ^ Shi Y, Seto E, Chang LS, Shenk T (October 1991). "Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein". Cell. 67 (2): 377–88. doi:10.1016/0092-8674(91)90189-6. PMID 1655281.
  7. ^ Zhu W, Lossie AC, Camper SA, Gumucio DL (April 1994). "Chromosomal localization of the transcription factor YY1 in the mouse and human". Mammalian Genome. 5 (4): 234–6. doi:10.1007/BF00360552. PMID 7912122.
  8. ^ "Entrez Gene: YY1 YY1 transcription factor".
  9. ^ Weintraub AS, Li CH, Zamudio AV, Sigova AA, Hannett NM, Day DS, et al. (December 2017). "YY1 Is a Structural Regulator of Enhancer-Promoter Loops". Cell. 171 (7): 1573–1588.e28. doi:10.1016/j.cell.2017.11.008. PMID 29224777.
  10. ^ a b Gabriele M, Vulto-van Silfhout AT, Germain PL, Vitriolo A, Kumar R, Douglas E, et al. (June 2017). "YY1 Haploinsufficiency Causes an Intellectual Disability Syndrome Featuring Transcriptional and Chromatin Dysfunction". American Journal of Human Genetics. 100 (6): 907–925. doi:10.1016/j.ajhg.2017.05.006. PMID 28575647.
  11. ^ "OMIM:GABRIELE-DE VRIES SYNDROME".
  12. ^ "Gabriele-de Vries Syndrome".
  13. ^ "YY1 - Collect information about clinic management and research projects". YY1.
  14. ^ Li M, Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee AS (July 2000). "ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1". Molecular and Cellular Biology. 20 (14): 5096–106. doi:10.1128/mcb.20.14.5096-5106.2000. PMC 85959. PMID 10866666.
  15. ^ a b c Yao YL, Yang WM, Seto E (September 2001). "Regulation of transcription factor YY1 by acetylation and deacetylation". Molecular and Cellular Biology. 21 (17): 5979–91. doi:10.1128/mcb.21.17.5979-5991.2001. PMC 87316. PMID 11486036.
  16. ^ Lee JS, Galvin KM, See RH, Eckner R, Livingston D, Moran E, Shi Y (May 1995). "Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300". Genes & Development. 9 (10): 1188–98. doi:10.1101/gad.9.10.1188. PMID 7758944.
  17. ^ Yang WM, Yao YL, Seto E (September 2001). "The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1". The EMBO Journal. 20 (17): 4814–25. doi:10.1093/emboj/20.17.4814. PMC 125595. PMID 11532945.
  18. ^ a b Yang WM, Yao YL, Sun JM, Davie JR, Seto E (October 1997). "Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family". The Journal of Biological Chemistry. 272 (44): 28001–7. doi:10.1074/jbc.272.44.28001. PMID 9346952.
  19. ^ Kalenik JL, Chen D, Bradley ME, Chen SJ, Lee TC (February 1997). "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1". Nucleic Acids Research. 25 (4): 843–9. doi:10.1093/nar/25.4.843. PMC 146511. PMID 9016636.
  20. ^ Shrivastava A, Saleque S, Kalpana GV, Artandi S, Goff SP, Calame K (December 1993). "Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc". Science. 262 (5141): 1889–92. doi:10.1126/science.8266081. PMID 8266081.
  21. ^ Yeh TS, Lin YM, Hsieh RH, Tseng MJ (October 2003). "Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch". The Journal of Biological Chemistry. 278 (43): 41963–9. doi:10.1074/jbc.M304353200. PMID 12913000.
  22. ^ García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M (June 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". The EMBO Journal. 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC 1171420. PMID 10369680.
  23. ^ Huang NE, Lin CH, Lin YS, Yu WC (June 2003). "Modulation of YY1 activity by SAP30". Biochemical and Biophysical Research Communications. 306 (1): 267–75. doi:10.1016/s0006-291x(03)00966-5. PMID 12788099.
  24. ^ Fu CY, Wang P, Tsai HJ (November 2017). "Competitive binding between Seryl-tRNA synthetase/YY1 complex and NFKB1 at the distal segment results in differential regulation of human vegfa promoter activity during angiogenesis". Nucleic Acids Research. 45 (5): 2423–2437. doi:10.1093/nar/gkw1187.

Further readingEdit

External linksEdit