Y+L amino acid transporter 2

Y+L amino acid transporter 2, also known as cationic amino acid transporter, y+ system, is a protein that in humans is encoded by the SLC7A6 gene.

SLC7A6
Identifiers
Aliases	SLC7A6, LAT-2, LAT3, y+LAT-2, solute carrier family 7 member 6
External IDs	OMIM: 605641; MGI: 2142598; HomoloGene: 62496; GeneCards: SLC7A6; OMA:SLC7A6 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16q22.1 Start 68,264,516 bp End 68,301,823 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 D3 Start 106,895,489 bp End 106,925,338 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart gastrocnemius muscle gastric mucosa subcutaneous adipose tissue tibialis anterior muscle left ventricle tibial nerve abdominal fat left lobe of thyroid gland right auricle Top expressed in spermatocyte primitive streak embryo neural tube external carotid artery abdominal wall epiblast ventricular zone internal carotid artery otic vesicle More reference expression data BioGPS n/a
Gene ontology Molecular function L-amino acid transmembrane transporter activity antiporter activity amino acid transmembrane transporter activity transmembrane transporter activity Cellular component integral component of membrane basolateral plasma membrane integral component of plasma membrane membrane plasma membrane intracellular membrane-bounded organelle Biological process cellular amino acid metabolic process amino acid transmembrane transport amino acid transport leukocyte migration L-alpha-amino acid transmembrane transport transmembrane transport protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9057 330836 Ensembl ENSG00000103064 ENSMUSG00000031904 UniProt Q92536 Q8BGK6 RefSeq (mRNA) NM_001076785 NM_003983 NM_178798 NM_001357381 NM_001357382 RefSeq (protein) NP_001070253 NP_003974 NP_001070253.1 NP_003974.3 NP_848913 NP_001344310 NP_001344311 Location (UCSC) Chr 16: 68.26 – 68.3 Mb Chr 8: 106.9 – 106.93 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• Heterodimeric amino acid transporter

Further reading

• Sekine Y, Nishibori Y, Akimoto Y, Kudo A, Ito N, Fukuhara D, Kurayama R, Higashihara E, Babu E, Kanai Y, Asanuma K, Nagata M, Majumdar A, Tryggvason K, Yan K (July 2009). "Amino acid transporter LAT3 is required for podocyte development and function". Journal of the American Society of Nephrology. 20 (7): 1586–96. doi:10.1681/ASN.2008070809. PMC 2709689. PMID 19443642.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (September 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Torrents D, Estévez R, Pineda M, Fernández E, Lloberas J, Shi YB, Zorzano A, Palacín M (December 1998). "Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. A candidate gene for lysinuric protein intolerance". The Journal of Biological Chemistry. 273 (49): 32437–45. doi:10.1074/jbc.273.49.32437. hdl:2445/176951. PMID 9829974.
• Bröer A, Wagner CA, Lang F, Bröer S (August 2000). "The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine". The Biochemical Journal. 349 Pt 3 (Pt 3): 787–95. doi:10.1042/bj3490787. PMC 1221206. PMID 10903140.
• Xu D, Hemler ME (August 2005). "Metabolic activation-related CD147-CD98 complex". Molecular & Cellular Proteomics. 4 (8): 1061–71. doi:10.1074/mcp.M400207-MCP200. PMC 1351277. PMID 15901826.