Xenohormesis explains how certain molecules such as plant polyphenols, which indicate stress in the plants, can have a longevity-conferring effect in consumers of plants (i.e. mammals). It was first used in the paper "Small molecules that regulate lifespan: evidence for xenohormesis" by David Sinclair and colleagues from the Harvard Medical School. Further studies then picked up the term.[unreliable medical source?]
If the plants an animal is eating are under stress, their increased polyphenol content may signal forthcoming famine conditions. It could be advantageous for the animal to begin to react—i.e. to hunker down to prepare for the lean times to come. The effects researchers have observed from resveratrol may be just such a response.
- Lamming, Dudley W.; Wood, Jason G.; Sinclair, David A. (2004). "Small molecules that regulate lifespan: Evidence for xenohormesis". Molecular Microbiology. 53 (4): 1003–9. doi:10.1111/j.1365-2958.2004.04209.x. PMID 15306006.
- Yun, A; Lee, P; Doux, J (2006). "Are we eating more than we think? Illegitimate signaling and xenohormesis as participants in the pathogenesis of obesity". Medical Hypotheses. 67 (1): 36–40. doi:10.1016/j.mehy.2005.11.022. PMID 16406352.
- Sajish, Mathew, and Paul Schimmel. "A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol." Nature 519.7543 (2015): 370-373. https://www.nature.com/nature/journal/v519/n7543/full/nature14028.html
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