William Duke may refer to:
- William Duke (civil servant) (1863–1924), governor of Bengal
- William Duke (artist) (1814–1853), Irish-born Australian artist
- William Duke (mathematician) (born 1958), American mathematician
- William B. Duke (1857–1926), American Hall of Fame racehorse trainer
- William Mark Duke (1879–1971), Canadian archbishop
This disambiguation page lists articles about people with the same name.
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