Metolazone edit
I just wrote an article about this medicine, and I'm really not sure what to do next. Are there any other sections I should write or areas that need expansion? Also, I'd appreciate some non-medical reviewers to comment on its accesibility to lay people. Thank you. — Knowledge Seeker দ 07:13, 23 January 2006 (UTC)
- The history section could be expanded. For instance, for which company was Dr. Shetty working for? What were the results of clinical trials? How long did the approval process take? Were any patents issued for this drug? etc.
- In the chemical structure section I'd explain what a thiazide is, since you refer to it quite prominently. The "sulfa" allergy mention should go into toxicity instead.
- The pharmacodynamics is a bit on the short side, and doesn't mention anything about bioaccumulation. Maybe you should consult some of the original literature in order to gather more info on the subject.
- I'd reformat weblink references to at least provide a "last accessed" date. See WP:CITE for more.
The article reads well but in general "feels" a bit short. Unfortunately I'm not the person to ask about "layperson readability" but a general guideline is to define obscure terminology in the article itself. I'll get around at some point in doing a high-res structure for the article. The current one looks a bit blurry, IMO. Good luck! -- Rune Welsh | ταλκ 11:29, 24 January 2006 (UTC)
- Thank you for your thoughtful review! I explained about thiazides, moved sulfonamide allergy to toxicity, and put the date accessed on the links. I'll do my best with the history, although history is notoriously difficult—especially for medical topics, where "history" has a special meaning and severly confounds searches. It's not easy to find information about the development of non-major drugs like metolazone. I was actually quite pleased I found out what I did, but I will keep working on it. I'll add some more to the bioaccumulation section as well tomorrow. I agree that the article is a bit short; I just don't know what else to add to it. I can write about its melting point and dosing regimens and so on although I don't think it's that useful—and I don't want to just add "filler". Perhaps I'll try to put the results of various studies in. I'll keep working. — Knowledge Seeker দ 07:57, 25 January 2006 (UTC)
- If you have access through databases of medical literature you could try to search for Dr. Shetty's publications. Also try a search on the US Patent Office website under Shetty's name or the IUPAC name of the drug (NOT the commercial name). That ought to yield something. Most common dosing regimens may not be completely out of place. For additional chemical info I think there's an infobox provided by WikiProject:Drugs for that purpose. -- Rune Welsh | ταλκ 04:42, 26 January 2006 (UTC)