WBP1

WW domain-binding protein 1 is a protein that in humans is encoded by the WBP1 gene.

WBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JMQ, 1K5R
Identifiers
Aliases	WBP1, WBP-1, WW domain binding protein 1
External IDs	OMIM: 606961; MGI: 104710; HomoloGene: 8267; GeneCards: WBP1; OMA:WBP1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p13.1 Start 74,458,400 bp End 74,460,891 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 C3 Start 83,096,025 bp End 83,098,540 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube pituitary gland amygdala nucleus accumbens anterior pituitary putamen caudate nucleus right adrenal cortex hippocampus proper left lobe of thyroid gland Top expressed in choroid plexus of fourth ventricle external carotid artery ventricular zone internal carotid artery vestibular sensory epithelium ganglionic eminence neural tube medial ganglionic eminence neural layer of retina maxillary prominence More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding WW domain binding Cellular component cellular component Biological process biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23559 22377 Ensembl ENSG00000239779 ENSMUSG00000030035 UniProt Q96G27 P97764 RefSeq (mRNA) NM_012477 NM_001083922 NM_001083923 NM_016757 RefSeq (protein) NP_036609 NP_001077391 NP_001077392 NP_058037 Location (UCSC) Chr 2: 74.46 – 74.46 Mb Chr 6: 83.1 – 83.1 Mb PubMed search
Wikidata
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The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands.

This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by a conserved region: XPPXY motif. The function of this protein has not been determined.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ludes-Meyers JH, Kil H, Bednarek AK, et al. (2004). "WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins". Oncogene. 23 (29): 5049–55. doi:10.1038/sj.onc.1207680. PMC 4143251. PMID 15064722.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jolliffe CN, Harvey KF, Haines BP, et al. (2001). "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4". Biochem. J. 351 Pt 3 (3): 557–65. doi:10.1042/0264-6021:3510557. PMC 1221394. PMID 11042109.
• Chen HI, Einbond A, Kwak SJ, et al. (1997). "Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands". J. Biol. Chem. 272 (27): 17070–7. doi:10.1074/jbc.272.27.17070. PMID 9202023.
• Pirozzi G, McConnell SJ, Uveges AJ, et al. (1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets". J. Biol. Chem. 272 (23): 14611–6. doi:10.1074/jbc.272.23.14611. PMID 9169421.