WASF3

Wiskott–Aldrich syndrome protein family member 3 is a protein that in humans is encoded by the WASF3 gene.

WASF3
Identifiers
Aliases	WASF3, Brush-1, SCAR3, WAVE3, WAS protein family member 3, WASP family member 3
External IDs	OMIM: 605068; MGI: 2658986; HomoloGene: 68527; GeneCards: WASF3; OMA:WASF3 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) Band 13q12.13 Start 26,557,683 bp End 26,688,948 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 G3 Start 146,321,795 bp End 146,410,425 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pars compacta pars reticulata paraflocculus of cerebellum lateral nuclear group of thalamus orbitofrontal cortex cerebellar vermis postcentral gyrus external globus pallidus Brodmann area 46 dorsal motor nucleus of vagus nerve Top expressed in ventral tegmental area neural layer of retina lobe of cerebellum cerebellar vermis dorsomedial hypothalamic nucleus mammillary body globus pallidus lateral hypothalamus lateral septal nucleus deep cerebellar nuclei More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding Cellular component cytoplasm extracellular exosome cytoskeleton lamellipodium postsynapse glutamatergic synapse Biological process positive regulation of myelination oligodendrocyte development actin filament polymerization cytoskeleton organization actin cytoskeleton organization lamellipodium assembly regulation of cell shape protein-containing complex assembly modification of postsynaptic actin cytoskeleton Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10810 245880 Ensembl ENSG00000132970 ENSMUSG00000029636 UniProt Q9UPY6 Q5T8P4 Q8VHI6 RefSeq (mRNA) NM_001291965 NM_006646 NM_145155 RefSeq (protein) NP_001278894 NP_006637 NP_006637.2 NP_660137 Location (UCSC) Chr 13: 26.56 – 26.69 Mb Chr 5: 146.32 – 146.41 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the Wiskott–Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to transduce signals that involve changes in cell shape, motility or function.

See also

• WASp (encoded by WAS gene)
• WASF1
• WASF2

Further reading

• Jones GE (2000). "Cellular signaling in macrophage migration and chemotaxis". J. Leukoc. Biol. 68 (5): 593–602. doi:10.1189/jlb.68.5.593. PMID 11073096. S2CID 14783521.
• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Schott DR, Chang JN, Deng G, et al. (1994). "A candidate tumor suppressor gene in human breast cancers". Cancer Res. 54 (6): 1393–6. PMID 8137235.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Bear JE, Rawls JF, Saxe CL (1998). "SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development". J. Cell Biol. 142 (5): 1325–35. doi:10.1083/jcb.142.5.1325. PMC 2149354. PMID 9732292.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
• Marchand JB, Kaiser DA, Pollard TD, Higgs HN (2001). "Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex". Nat. Cell Biol. 3 (1): 76–82. doi:10.1038/35050590. PMID 11146629. S2CID 30437883.
• Millard TH, Machesky LM (2001). "The Wiskott–Aldrich syndrome protein (WASP) family". Trends Biochem. Sci. 26 (3): 198–9. doi:10.1016/S0968-0004(01)01788-1. PMID 11246027.
• Sossey-Alaoui K, Su G, Malaj E, et al. (2002). "WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastoma". Oncogene. 21 (38): 5967–74. doi:10.1038/sj.onc.1205734. PMID 12185600.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sossey-Alaoui K, Head K, Nowak N, Cowell JK (2003). "Genomic organization and expression profile of the human and mouse WAVE gene family". Mamm. Genome. 14 (5): 314–22. doi:10.1007/s00335-002-2247-7. PMID 12856283. S2CID 1042966.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
• Oda A, Miki H, Wada I, et al. (2005). "WAVE/Scars in platelets". Blood. 105 (8): 3141–8. doi:10.1182/blood-2003-04-1319. PMID 15280206. S2CID 6674815.
• Kashiwagi H, Shiraga M, Kato H, et al. (2005). "Expression and subcellular localization of WAVE isoforms in the megakaryocyte/platelet lineage". J. Thromb. Haemost. 3 (2): 361–8. doi:10.1111/j.1538-7836.2004.01082.x. PMID 15670045.
• Stovold CF, Millard TH, Machesky LM (2006). "Inclusion of Scar/WAVE3 in a similar complex to Scar/WAVE1 and 2". BMC Cell Biol. 6 (1): 11. doi:10.1186/1471-2121-6-11. PMC 555569. PMID 15752430.
• Sossey-Alaoui K, Li X, Ranalli TA, Cowell JK (2005). "WAVE3-mediated cell migration and lamellipodia formation are regulated downstream of phosphatidylinositol 3-kinase". J. Biol. Chem. 280 (23): 21748–55. doi:10.1074/jbc.M500503200. PMID 15826941.
• Sossey-Alaoui K, Ranalli TA, Li X, et al. (2005). "WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, and MMP-9 expression". Exp. Cell Res. 308 (1): 135–45. doi:10.1016/j.yexcr.2005.04.011. PMID 15907837.