Tryptophanyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the WARS gene.[5][6][7]

WARS1
Protein WARS PDB 1o5t.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesWARS1, Tryptophanyl-tRNA synthetase, cytoplasmic, GAMMA-2, IFI53, IFP53, tryptophanyl-tRNA synthetase, HMN9, tryptophanyl-tRNA synthetase 1, WARS
External IDsOMIM: 191050 MGI: 104630 HomoloGene: 3084 GeneCards: WARS1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004184
NM_173701
NM_213645
NM_213646

NM_001164314
NM_001164488
NM_011710

RefSeq (protein)

NP_004175
NP_776049
NP_998810
NP_998811

NP_001157786
NP_001157960
NP_035840

Location (UCSC)Chr 14: 100.33 – 100.38 MbChr 12: 108.86 – 108.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene.[7]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000140105 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021266 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Buwitt U, Flohr T, Bottger EC (Mar 1992). "Molecular cloning and characterization of an interferon induced human cDNA with sequence homology to a mammalian peptide chain release factor". EMBO J. 11 (2): 489–96. doi:10.1002/j.1460-2075.1992.tb05079.x. PMC 556479. PMID 1537332.
  6. ^ Fleckner J, Rasmussen HH, Justesen J (Feb 1992). "Human interferon gamma potently induces the synthesis of a 55-kDa protein (gamma 2) highly homologous to rabbit peptide chain release factor and bovine tryptophanyl-tRNA synthetase". Proc Natl Acad Sci U S A. 88 (24): 11520–4. doi:10.1073/pnas.88.24.11520. PMC 53167. PMID 1763065.
  7. ^ a b "Entrez Gene: WARS tryptophanyl-tRNA synthetase".

Further readingEdit