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The ventral pallidum (VP) is a structure within the basal ganglia of the brain. It is an output nucleus whose fibres project to thalamic nuclei, such as the ventral anterior nucleus, the ventral lateral nucleus, and the medial dorsal nucleus. The VP is a core component of the reward system which forms part of the limbic loop of the basal ganglia,[1] a pathway involved in the regulation of motivational salience, behavior, and emotions. It is involved in addiction.

Ventral pallidum
Identifiers
NeuroNames794
NeuroLex IDbirnlex_1674
TAA14.1.09.438
FMA77613
Anatomical terms of neuroanatomy

The VP contains one of the brain's pleasure centers, which mediates the subjective perception of pleasure that results from "consuming" certain rewarding stimuli (e.g., palatable food).[1]

Contents

AnatomyEdit

The ventral pallidum lies within the basal ganglia, a group of subcortical nuclei. Along with the external globus pallidus, it is separated from other basal ganglia nuclei by the anterior commissure.

Limbic loopEdit

The limbic loop is a functional pathway of the basal ganglia, in which the ventral pallidum is involved. It (and the internal globus pallidus and substantia nigra pars reticulata) receives input from the temporal lobes, and the hippocampus via the ventral striatum. The information is relayed to the medial dorsal and ventral anterior nuclei of the thalamus.

Role in addictionEdit

The ventral pallidum receives dopaminergic inputs from the ventral tegmental area.[2] The ventral pallidum also receives GABAergic inputs from the nucleus accumbens.[3] It acts in part as a relay nucleus from the nucleus accumbens to the medial dorsal nucleus. The nucleus accumbens projects to the medial dorsal nucleus via GABAergic medium spiny neurons. The rewarding effects of addictive drugs are mediated in part through their effect on the VP.[4]

ReferencesEdit

  1. ^ a b Berridge KC, Kringelbach ML (May 2015). "Pleasure systems in the brain". Neuron. 86 (3): 646–664. doi:10.1016/j.neuron.2015.02.018. PMC 4425246. PMID 25950633.
  2. ^ Smith Y, Keival JZ (2000). "Anatomy of the Dopamine system in the Basal Ganglia". Trends in Neurosciences. 23 (10): 28–33. doi:10.1016/S1471-1931(00)00023-9.
  3. ^ Pierce R C, Kumaresan V (2006). "The Mesolimbic dopamine system: The final common pathway for the reinforcing effect of drugs of abuse?". Neuroscience & Biobehavioral Reviews. 30: 215–238. doi:10.1016/j.neubiorev.2005.04.016.
  4. ^ Ikemoto S (2010). "Brain reward circuitry beyond the mesolimbic dopamine system: a neurobiological theory". Neurosci Biobehav Rev. 35 (2): 129–50. doi:10.1016/j.neubiorev.2010.02.001. PMC 2894302. PMID 20149820.

Additional SourcesEdit

  • Martin J.H. Neuroanatomy Text and Atlas. 3rd Edition 2003: Chapter 14