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Van Wyck is an unincorporated community in the panhandle of Lancaster County, South Carolina, United States. The name "Van Wyck" comes from a Dutch habitational name for someone from any of the many places in the Netherlands named Wijk, from the Dutch word wijk, meaning "district" or "settlement". There are several ways of pronouncing the name of the community—"Van Wick", "Van Wack", and "Van Wike". Families who have lived in the area since its founding in the 1880s generally pronounce it "Van Wack". On August 15, 2017, the residents of the community voted to incorporate it as a town.
Van Wyck is the hometown of Olympian sprint athlete Shawn Crawford, gold and silver medalist from the 2004 games held in Athens, Greece.
The Adam Ivy House and Massey-Doby-Nisbet House were listed on the National Register of Historic Places in 1990.