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Serine/threonine-protein kinase VRK2 is an enzyme that in humans is encoded by the VRK2 gene.[5]

VRK2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesVRK2, vaccinia related kinase 2
External IDsMGI: 1917172 HomoloGene: 55966 GeneCards: VRK2
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for VRK2
Genomic location for VRK2
Band2p16.1Start57,907,651 bp[1]
End58,159,920 bp[1]
RNA expression pattern
PBB GE VRK2 205126 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001252447
NM_027260

RefSeq (protein)

NP_001239376
NP_081536

Location (UCSC)Chr 2: 57.91 – 58.16 MbChr 11: 26.47 – 26.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, leukocytes, fetal liver, and carcinomas. Its protein localizes to the endoplasmic reticulum and has been shown to phosphorylate casein and undergo autophosphorylation. While several transcript variants may exist for this gene, the full-length nature of only one has been biologically validated to date.[5]

ReferencesEdit

Further readingEdit