VPS52

Vacuolar protein sorting-associated protein 52 homolog is a protein that in humans is encoded by the VPS52 gene.

VPS52
Identifiers
Aliases	VPS52, ARE1, SAC2, SACM2L, dJ1033B10.5, GARP complex subunit, VPS52 subunit of GARP complex
External IDs	OMIM: 603443 MGI: 1330304 HomoloGene: 5756 GeneCards: VPS52
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.32 Start 33,250,272 bp End 33,272,047 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 B1 Start 34,174,786 bp End 34,186,009 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland right uterine tube pituitary gland left lobe of thyroid gland spleen anterior pituitary fundus skin of abdomen body of pancreas tibial nerve Top expressed in superior frontal gyrus lip spermatocyte yolk sac cerebellar cortex esophagus neural tube entorhinal cortex spermatid seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function syntaxin binding protein binding Cellular component perinuclear region of cytoplasm recycling endosome EARP complex endosome Golgi apparatus endosome membrane membrane trans-Golgi network membrane GARP complex cytosol Biological process protein transport ectodermal cell differentiation embryonic ectodermal digestive tract development endocytic recycling lysosomal transport Golgi to vacuole transport retrograde transport, endosome to Golgi Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6293 224705 Ensembl ENSG00000236014 ENSG00000206286 ENSG00000223501 ENSG00000224455 ENSG00000225590 ENSG00000223618 ENSG00000228425 ENSMUSG00000024319 UniProt Q8N1B4 Q8C754 RefSeq (mRNA) NM_001289174 NM_001289175 NM_001289176 NM_022553 NM_172620 NM_001357329 NM_001357330 NM_001379410 NM_001379411 RefSeq (protein) NP_001276103 NP_001276104 NP_001276105 NP_072047 NP_766208 NP_001344258 NP_001344259 NP_001366339 NP_001366340 Location (UCSC) Chr 6: 33.25 – 33.27 Mb Chr 17: 34.17 – 34.19 Mb PubMed search
Wikidata
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This gene encodes a protein that is similar to the yeast suppressor of actin mutations 2 gene. The yeast protein forms a subunit of the tetrameric Golgi-associated retrograde protein complex that is involved in vesicle trafficking from both early and late endosomes, back to the trans-Golgi network. This gene is located on chromosome 6 in a head-to-head orientation with the gene encoding ribosomal protein S18.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Stephens R, Horton R, Humphray S, et al. (1999). "Gene organisation, sequence variation and isochore structure at the centromeric boundary of the human MHC". J. Mol. Biol. 291 (4): 789–99. doi:10.1006/jmbi.1999.3004. PMID 10452889.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Liewen H, Meinhold-Heerlein I, Oliveira V, et al. (2005). "Characterization of the human GARP (Golgi associated retrograde protein) complex". Exp. Cell Res. 306 (1): 24–34. doi:10.1016/j.yexcr.2005.01.022. PMID 15878329.