hVamp6/Vps39-like protein is a protein that in humans is encoded by the VPS39 gene.[5][6]

VPS39
Identifiers
AliasesVPS39, TLP, VAM6, hVam6p, HOPS complex subunit, VPS39 subunit of HOPS complex
External IDsOMIM: 612188; MGI: 2443189; HomoloGene: 41025; GeneCards: VPS39; OMA:VPS39 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001301138
NM_015289

NM_147153
NM_178851
NM_001363053
NM_001363054

RefSeq (protein)

NP_001288067
NP_056104

NP_671495
NP_849182
NP_001349982
NP_001349983

Location (UCSC)Chr 15: 42.16 – 42.21 MbChr 2: 120.15 – 120.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein that may promote clustering and fusion of late endosomes and lysosomes. The protein may also act as an adaptor protein that modulates the transforming growth factor-beta response by coupling the transforming growth factor-beta receptor complex to the Smad pathway.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166887Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027291Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Caplan S, Hartnell LM, Aguilar RC, Naslavsky N, Bonifacino JS (Jul 2001). "Human Vam6p promotes lysosome clustering and fusion in vivo". J Cell Biol. 154 (1): 109–122. doi:10.1083/jcb.200102142. PMC 2196876. PMID 11448994.
  6. ^ a b "Entrez Gene: VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)".

Further reading

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