Protein VPRBP is a protein that in humans is encoded by the VPRBP gene.[5][6][7]

DCAF1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDCAF1, VPRBP, Vpr (HIV-1) binding protein, DDB1 and CUL4 associated factor 1, RIP
External IDsOMIM: 617259; MGI: 2445220; HomoloGene: 8805; GeneCards: DCAF1; OMA:DCAF1 - orthologs
EC number2.7.11.1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001015507
NM_001373930
NM_001373931

RefSeq (protein)

NP_001015507
NP_001360859
NP_001360860

Location (UCSC)Chr 3: 51.4 – 51.5 MbChr 9: 106.7 – 106.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

edit

VPRBP has been shown to interact with Merlin.[8]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145041Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040325Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhao LJ, Mukherjee S, Narayan O (June 1994). "Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein". The Journal of Biological Chemistry. 269 (22): 15577–82. doi:10.1016/S0021-9258(17)40719-8. PMID 8195203.
  6. ^ Zhang S, Feng Y, Narayan O, Zhao LJ (January 2001). "Cytoplasmic retention of HIV-1 regulatory protein Vpr by protein-protein interaction with a novel human cytoplasmic protein VprBP". Gene. 263 (1–2): 131–40. doi:10.1016/S0378-1119(00)00583-7. PMID 11223251.
  7. ^ "Entrez Gene: VPRBP Vpr (HIV-1) binding protein".
  8. ^ Huang J, Chen J (July 2008). "VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation". Oncogene. 27 (29): 4056–64. doi:10.1038/onc.2008.44. PMID 18332868.

Further reading

edit