V-set and immunoglobulin domain containing 4

V-set and immunoglobulin domain containing 4 is a protein that in humans is encoded by the VSIG4 gene.[5]

VSIG4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesVSIG4, CRIg, Z39IG, V-set and immunoglobulin domain containing 4
External IDsOMIM: 300353; MGI: 2679720; HomoloGene: 48515; GeneCards: VSIG4; OMA:VSIG4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007268
NM_001100431
NM_001184830
NM_001184831
NM_001257403

NM_177789

RefSeq (protein)

NP_001093901
NP_001171759
NP_001171760
NP_001244332
NP_009199

NP_808457

Location (UCSC)Chr X: 66.02 – 66.04 MbChr X: 95.29 – 95.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000155659Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044206Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: V-set and immunoglobulin domain containing 4". Retrieved 2016-06-13.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.