Other Pages: Ataxin 3 (No Data); ATXN3 (Redirect -> ataxin); AT3 (Redirect -> 9M14 Malyutka); At3 (No Data); ATX3 (No Data); Atx3 (No Data); JOS (No Data); Jos (Unknown Data); MJD (DisAmbig); Mjd (No Data); MJD1 (No Data); Mjd1 (No Data); SCA3 (No Data); Sca3 (No Data); Ataxin (Unknown Data); 9M14 Malyutka (Unknown Data);
INFO: Beginning work on COL4A3... {November 7, 2007 12:17:26 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:19:08 PM PST}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Collagen, type IV, alpha 3 (Goodpasture antigen)
| HGNCid = 2204
| Symbol = COL4A3
| AltSymbols =;
| OMIM = 120070
| ECnumber =
| Homologene = 68033
| MGIid = 104688
| GeneAtlas_image1 = PBB_GE_COL4A3_214641_at_tn.png
| GeneAtlas_image2 = PBB_GE_COL4A3_216893_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_COL4A3_222073_at_tn.png
| Function = {{GNF_GO|id=GO:0005178 |text = integrin binding}} {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008191 |text = metalloendopeptidase inhibitor activity}}
| Component = {{GNF_GO|id=GO:0005581 |text = collagen}} {{GNF_GO|id=GO:0005587 |text = collagen type IV}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006817 |text = phosphate transport}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0006919 |text = caspase activation}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0008015 |text = circulation}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0016525 |text = negative regulation of angiogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1285
| Hs_Ensembl = ENSG00000169031
| Hs_RefseqProtein = NP_000082
| Hs_RefseqmRNA = NM_000091
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 227810928
| Hs_GenLoc_end = 227884953
| Hs_Uniprot = Q01955
| Mm_EntrezGene = 12828
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_007734
| Mm_RefseqProtein = NP_031760
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Collagen, type IV, alpha 3 (Goodpasture antigen)''', also known as '''COL4A3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. There are multiple alternate transcripts that appear to be unique to this human alpha 3 gene and alternate splicing is restricted to the six exons that encode this C-terminal domain. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Some exons of this gene are interspersed with exons of an uncharacterized gene which is on the opposite strand.<ref>{{cite web | title = Entrez Gene: COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1285| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hinek A |title=Nature and the multiple functions of the 67-kD elastin-/laminin binding protein. |journal=Cell Adhes. Commun. |volume=2 |issue= 3 |pages= 185-93 |year= 1995 |pmid= 7827955 |doi= }}
*{{cite journal | author=Ständer M, Naumann U, Wick W, Weller M |title=Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth. |journal=Cell Tissue Res. |volume=296 |issue= 2 |pages= 221-7 |year= 1999 |pmid= 10382266 |doi= }}
*{{cite journal | author=Kurpakus Wheater M, Kernacki KA, Hazlett LD |title=Corneal cell proteins and ocular surface pathology. |journal=Biotechnic & histochemistry : official publication of the Biological Stain Commission |volume=74 |issue= 3 |pages= 146-59 |year= 1999 |pmid= 10416788 |doi= }}
*{{cite journal | author=Pescucci C, Longo I, Bruttini M, ''et al.'' |title=Type-IV collagen related diseases. |journal=J. Nephrol. |volume=16 |issue= 2 |pages= 314-6 |year= 2003 |pmid= 12768082 |doi= }}
*{{cite journal | author=Torra R, Tazón-Vega B, Ars E, Ballarín J |title=Collagen type IV (alpha3-alpha4) nephropathy: from isolated haematuria to renal failure. |journal=Nephrol. Dial. Transplant. |volume=19 |issue= 10 |pages= 2429-32 |year= 2005 |pmid= 15280517 |doi= 10.1093/ndt/gfh435 }}
*{{cite journal | author=Rana K, Wang YY, Buzza M, ''et al.'' |title=The genetics of thin basement membrane nephropathy. |journal=Semin. Nephrol. |volume=25 |issue= 3 |pages= 163-70 |year= 2005 |pmid= 15880327 |doi= }}
*{{cite journal | author=Maziers N, Dahan K, Pirson Y |title=[From Alport syndrome to benign familial hematuria: clinical and genetic aspect] |journal=Nephrol. Ther. |volume=1 |issue= 2 |pages= 90-100 |year= 2006 |pmid= 16895672 |doi= 10.1016/j.nephro.2005.03.005 }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:20:39 PM PST}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CYP1A2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2hi4.
| PDB = {{PDB2|2hi4}}
| Name = Cytochrome P450, family 1, subfamily A, polypeptide 2
| HGNCid = 2596
| Symbol = CYP1A2
| AltSymbols =; CP12; P3-450; P450(PA)
| OMIM = 124060
| ECnumber =
| Homologene = 68082
| MGIid = 88589
| GeneAtlas_image1 = PBB_GE_CYP1A2_207609_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CYP1A2_207608_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0009055 |text = electron carrier activity}} {{GNF_GO|id=GO:0019825 |text = oxygen binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0050381 |text = unspecific monooxygenase activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1544
| Hs_Ensembl = ENSG00000140505
| Hs_RefseqProtein = NP_000752
| Hs_RefseqmRNA = NM_000761
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 72828237
| Hs_GenLoc_end = 72835994
| Hs_Uniprot = P05177
| Mm_EntrezGene = 13077
| Mm_Ensembl = ENSMUSG00000032310
| Mm_RefseqmRNA = NM_009993
| Mm_RefseqProtein = NP_034123
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 57475074
| Mm_GenLoc_end = 57481792
| Mm_Uniprot = P00186
}}
}}
'''Cytochrome P450, family 1, subfamily A, polypeptide 2''', also known as '''CYP1A2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.<ref>{{cite web | title = Entrez Gene: CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1544| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Smith G, Stubbins MJ, Harries LW, Wolf CR |title=Molecular genetics of the human cytochrome P450 monooxygenase superfamily. |journal=Xenobiotica |volume=28 |issue= 12 |pages= 1129-65 |year= 1999 |pmid= 9890157 |doi= }}
*{{cite journal | author=Landi MT, Sinha R, Lang NP, Kadlubar FF |title=Human cytochrome P4501A2. |journal=IARC Sci. Publ. |volume= |issue= 148 |pages= 173-95 |year= 1999 |pmid= 10493258 |doi= }}
*{{cite journal | author=Nelson DR, Zeldin DC, Hoffman SM, ''et al.'' |title=Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. |journal=Pharmacogenetics |volume=14 |issue= 1 |pages= 1-18 |year= 2004 |pmid= 15128046 |doi= }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:21:48 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CYP2C19_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1r9o.
| PDB = {{PDB2|1r9o}}
| Name = Cytochrome P450, family 2, subfamily C, polypeptide 19
| HGNCid = 2621
| Symbol = CYP2C19
| AltSymbols =; CPCJ; CYP 2C; CYP2C; P450C2C; P450IIC19
| OMIM = 124020
| ECnumber =
| Homologene = 86659
| MGIid = 1306818
| GeneAtlas_image1 = PBB_GE_CYP2C19_216058_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0016712 |text = oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen}} {{GNF_GO|id=GO:0018675 |text = (S)-limonene 6-monooxygenase activity}} {{GNF_GO|id=GO:0018676 |text = (S)-limonene 7-monooxygenase activity}} {{GNF_GO|id=GO:0019825 |text = oxygen binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1557
| Hs_Ensembl = ENSG00000165841
| Hs_RefseqProtein = NP_000760
| Hs_RefseqmRNA = NM_000769
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 96512371
| Hs_GenLoc_end = 96603007
| Hs_Uniprot = P33261
| Mm_EntrezGene = 13098
| Mm_Ensembl = ENSMUSG00000025003
| Mm_RefseqmRNA = NM_010003
| Mm_RefseqProtein = NP_034133
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 39564182
| Mm_GenLoc_end = 39621840
| Mm_Uniprot = Q6PER7
}}
}}
'''Cytochrome P450, family 2, subfamily C, polypeptide 19''', also known as '''CYP2C19''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.<ref>{{cite web | title = Entrez Gene: CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1557| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Goldstein JA, de Morais SM |title=Biochemistry and molecular biology of the human CYP2C subfamily. |journal=Pharmacogenetics |volume=4 |issue= 6 |pages= 285-99 |year= 1995 |pmid= 7704034 |doi= }}
*{{cite journal | author=Smith G, Stubbins MJ, Harries LW, Wolf CR |title=Molecular genetics of the human cytochrome P450 monooxygenase superfamily. |journal=Xenobiotica |volume=28 |issue= 12 |pages= 1129-65 |year= 1999 |pmid= 9890157 |doi= }}
*{{cite journal | author=Ding X, Kaminsky LS |title=Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. |journal=Annu. Rev. Pharmacol. Toxicol. |volume=43 |issue= |pages= 149-73 |year= 2003 |pmid= 12171978 |doi= 10.1146/annurev.pharmtox.43.100901.140251 }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on DMPK... {November 7, 2007 12:21:48 PM PST}
UPLOAD: Added new Image to wiki: {November 7, 2007 12:23:01 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:23:29 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_DMPK_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wt6.
| PDB = {{PDB2|1wt6}}
| Name = Dystrophia myotonica-protein kinase
| HGNCid = 2933
| Symbol = DMPK
| AltSymbols =; DM; DM1; DM1PK; DMK; MDPK; MT-PK
| OMIM = 605377
| ECnumber =
| Homologene = 3247
| MGIid = 94906
| GeneAtlas_image1 = PBB_GE_DMPK_37996_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_DMPK_217066_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_DMPK_217661_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0008016 |text = regulation of heart contraction}} {{GNF_GO|id=GO:0051056 |text = regulation of small GTPase mediated signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1760
| Hs_Ensembl = ENSG00000104936
| Hs_RefseqProtein = NP_001075029
| Hs_RefseqmRNA = NM_001081560
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 50965579
| Hs_GenLoc_end = 50977469
| Hs_Uniprot = Q09013
| Mm_EntrezGene = 13400
| Mm_Ensembl = ENSMUSG00000030409
| Mm_RefseqmRNA = XM_986224
| Mm_RefseqProtein = XP_991318
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 18242463
| Mm_GenLoc_end = 18252340
| Mm_Uniprot = Q05CL1
}}
}}
'''Dystrophia myotonica-protein kinase''', also known as '''DMPK''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.<ref>{{cite web | title = Entrez Gene: DMPK dystrophia myotonica-protein kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1760| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Groenen P, Wieringa B |title=Expanding complexity in myotonic dystrophy. |journal=Bioessays |volume=20 |issue= 11 |pages= 901-12 |year= 1999 |pmid= 9872056 |doi= 10.1002/(SICI)1521-1878(199811)20:11<901::AID-BIES5>3.0.CO;2-0 }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:26:07 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_HLA-DRB5_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1aqd.
| PDB = {{PDB2|1aqd}}, {{PDB2|1d5m}}, {{PDB2|1dlh}}, {{PDB2|1fv1}}, {{PDB2|1fyt}}, {{PDB2|1h15}}, {{PDB2|1hqr}}, {{PDB2|1hxy}}, {{PDB2|1j8h}}, {{PDB2|1jwm}}, {{PDB2|1jws}}, {{PDB2|1jwu}}, {{PDB2|1kg0}}, {{PDB2|1klg}}, {{PDB2|1klu}}, {{PDB2|1lo5}}, {{PDB2|1pyw}}, {{PDB2|1r5i}}, {{PDB2|1seb}}, {{PDB2|1sje}}, {{PDB2|1sjh}}, {{PDB2|1t5w}}, {{PDB2|1t5x}}, {{PDB2|1zgl}}, {{PDB2|2g9h}}, {{PDB2|2iam}}, {{PDB2|2ian}}, {{PDB2|2icw}}, {{PDB2|2ipk}}, {{PDB2|2oje}}
| Name = Major histocompatibility complex, class II, DR beta 5
| HGNCid = 4953
| Symbol = HLA-DRB5
| AltSymbols =;
| OMIM = 604776
| ECnumber =
| Homologene = 88657
| MGIid =
| Function = {{GNF_GO|id=GO:0032395 |text = MHC class II receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042613 |text = MHC class II protein complex}}
| Process = {{GNF_GO|id=GO:0002504 |text = antigen processing and presentation of peptide or polysaccharide antigen via MHC class II}} {{GNF_GO|id=GO:0006955 |text = immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3127
| Hs_Ensembl =
| Hs_RefseqProtein = NP_002116
| Hs_RefseqmRNA = NM_002125
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Major histocompatibility complex, class II, DR beta 5''', also known as '''HLA-DRB5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.<ref>{{cite web | title = Entrez Gene: HLA-DRB5 major histocompatibility complex, class II, DR beta 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3127| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Lau M, Terasaki PI, Park MS |title=International Cell Exchange, 1994. |journal=Clinical transplants |volume= |issue= |pages= 467-88 |year= 1995 |pmid= 7547576 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on RBL1... {November 7, 2007 12:32:50 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:33:36 PM PST}
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| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Retinoblastoma-like 1 (p107)
| HGNCid = 9893
| Symbol = RBL1
| AltSymbols =; PRB1; CP107; MGC40006; p107
| OMIM = 116957
| ECnumber =
| Homologene = 2172
| MGIid = 103300
| GeneAtlas_image1 = PBB_GE_RBL1_205296_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0043550 |text = regulation of lipid kinase activity}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5933
| Hs_Ensembl = ENSG00000080839
| Hs_RefseqProtein = NP_002886
| Hs_RefseqmRNA = NM_002895
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 35058166
| Hs_GenLoc_end = 35157824
| Hs_Uniprot = P28749
| Mm_EntrezGene = 19650
| Mm_Ensembl = ENSMUSG00000027641
| Mm_RefseqmRNA = NM_011249
| Mm_RefseqProtein = NP_035379
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 156837339
| Mm_GenLoc_end = 156895960
| Mm_Uniprot = Q3U1D4
}}
}}
'''Retinoblastoma-like 1 (p107)''', also known as '''RBL1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: RBL1 retinoblastoma-like 1 (p107)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5933| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:36:09 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_S100A8_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1mr8.
| PDB = {{PDB2|1mr8}}, {{PDB2|1xk4}}
| Name = S100 calcium binding protein A8
| HGNCid = 10498
| Symbol = S100A8
| AltSymbols =; MIF; 60B8AG; CAGA; CFAG; CGLA; CP-10; L1Ag; MA387; MRP8; NIF; P8
| OMIM = 123885
| ECnumber =
| Homologene = 2225
| MGIid = 88244
| GeneAtlas_image1 = PBB_GE_S100A8_202917_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6279
| Hs_Ensembl = ENSG00000143546
| Hs_RefseqProtein = NP_002955
| Hs_RefseqmRNA = NM_002964
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 151629132
| Hs_GenLoc_end = 151630288
| Hs_Uniprot = P05109
| Mm_EntrezGene = 20201
| Mm_Ensembl = ENSMUSG00000056054
| Mm_RefseqmRNA = NM_013650
| Mm_RefseqProtein = NP_038678
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 90755012
| Mm_GenLoc_end = 90755961
| Mm_Uniprot = Q53X15
}}
}}
'''S100 calcium binding protein A8''', also known as '''S100A8''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis.<ref>{{cite web | title = Entrez Gene: S100A8 S100 calcium binding protein A8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6279| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Schäfer BW, Heizmann CW |title=The S100 family of EF-hand calcium-binding proteins: functions and pathology. |journal=Trends Biochem. Sci. |volume=21 |issue= 4 |pages= 134-40 |year= 1996 |pmid= 8701470 |doi= }}
*{{cite journal | author=Kerkhoff C, Klempt M, Sorg C |title=Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9). |journal=Biochim. Biophys. Acta |volume=1448 |issue= 2 |pages= 200-11 |year= 1999 |pmid= 9920411 |doi= }}
*{{cite journal | author=Nacken W, Roth J, Sorg C, Kerkhoff C |title=S100A9/S100A8: Myeloid representatives of the S100 protein family as prominent players in innate immunity. |journal=Microsc. Res. Tech. |volume=60 |issue= 6 |pages= 569-80 |year= 2003 |pmid= 12645005 |doi= 10.1002/jemt.10299 }}
*{{cite journal | author=Roth J, Vogl T, Sorg C, Sunderkötter C |title=Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules. |journal=Trends Immunol. |volume=24 |issue= 4 |pages= 155-8 |year= 2004 |pmid= 12697438 |doi= }}
}}
{{refend}}
{{protein-stub}}
{November 7, 2007 12:23:01 PM PST} 
