- INFO: Beginning work on ADRB3... {November 7, 2007 12:39:53 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:40:40 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Adrenergic, beta-3-, receptor
| HGNCid = 288
| Symbol = ADRB3
| AltSymbols =; BETA3AR
| OMIM = 109691
| ECnumber =
| Homologene = 37250
| MGIid = 87939
| GeneAtlas_image1 = PBB_GE_ADRB3_206812_at_tn.png
| GeneAtlas_image2 = PBB_GE_ADRB3_217303_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0015052 |text = beta3-adrenergic receptor activity}} {{GNF_GO|id=GO:0031699 |text = beta-3 adrenergic receptor binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0051380 |text = norepinephrine binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0043235 |text = receptor complex}}
| Process = {{GNF_GO|id=GO:0002024 |text = diet induced thermogenesis}} {{GNF_GO|id=GO:0002025 |text = norepinephrine-epinephrine vasodilation during regulation of blood pressure}} {{GNF_GO|id=GO:0002032 |text = arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006091 |text = generation of precursor metabolites and energy}} {{GNF_GO|id=GO:0006112 |text = energy reserve metabolic process}} {{GNF_GO|id=GO:0006898 |text = receptor-mediated endocytosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007190 |text = adenylate cyclase activation}} {{GNF_GO|id=GO:0009409 |text = response to cold}} {{GNF_GO|id=GO:0031649 |text = heat generation}} {{GNF_GO|id=GO:0040015 |text = negative regulation of body size}} {{GNF_GO|id=GO:0043410 |text = positive regulation of MAPKKK cascade}} {{GNF_GO|id=GO:0050873 |text = brown fat cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 155
| Hs_Ensembl = ENSG00000188778
| Hs_RefseqProtein = NP_000016
| Hs_RefseqmRNA = NM_000025
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 37939673
| Hs_GenLoc_end = 37943341
| Hs_Uniprot = P13945
| Mm_EntrezGene = 11556
| Mm_Ensembl = ENSMUSG00000031489
| Mm_RefseqmRNA = NM_013462
| Mm_RefseqProtein = NP_038490
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 28691712
| Mm_GenLoc_end = 28695524
| Mm_Uniprot = Q3UP63
}}
}}
'''Adrenergic, beta-3-, receptor''', also known as '''ADRB3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The ADRB3 gene product, beta-3-adrenergic receptor, is located mainly in adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Beta adrenergic receptors are involved in the epenephrine and norepinephrine-induced activation of adenylate cyclase through the action of G proteins.<ref>{{cite web | title = Entrez Gene: ADRB3 adrenergic, beta-3-, receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=155| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ALPL... {November 7, 2007 12:41:50 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:42:30 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Alkaline phosphatase, liver/bone/kidney
| HGNCid = 438
| Symbol = ALPL
| AltSymbols =; AP-TNAP; FLJ40094; HOPS; MGC161443; TNAP; TNSALP
| OMIM = 171760
| ECnumber =
| Homologene = 37314
| MGIid = 87983
| GeneAtlas_image1 = PBB_GE_ALPL_215783_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004035 |text = alkaline phosphatase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001503 |text = ossification}} {{GNF_GO|id=GO:0008152 |text = metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 249
| Hs_Ensembl = ENSG00000162551
| Hs_RefseqProtein = NP_000469
| Hs_RefseqmRNA = NM_000478
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 21708452
| Hs_GenLoc_end = 21777492
| Hs_Uniprot = P05186
| Mm_EntrezGene = 11647
| Mm_Ensembl = ENSMUSG00000028766
| Mm_RefseqmRNA = NM_007431
| Mm_RefseqProtein = NP_031457
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 137013809
| Mm_GenLoc_end = 137068395
| Mm_Uniprot = Q3TJD3
}}
}}
'''Alkaline phosphatase, liver/bone/kidney''', also known as '''ALPL''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to a disorder known as hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms.<ref>{{cite web | title = Entrez Gene: ALPL alkaline phosphatase, liver/bone/kidney| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=249| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Mornet E |title=Hypophosphatasia: the mutations in the tissue-nonspecific alkaline phosphatase gene. |journal=Hum. Mutat. |volume=15 |issue= 4 |pages= 309-15 |year= 2000 |pmid= 10737975 |doi= 10.1002/(SICI)1098-1004(200004)15:4<309::AID-HUMU2>3.0.CO;2-C }}
*{{cite journal | author=Khandwala HM, Mumm S, Whyte MP |title=Low serum alkaline phosphatase activity and pathologic fracture: case report and brief review of hypophosphatasia diagnosed in adulthood. |journal=Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists |volume=12 |issue= 6 |pages= 676-81 |year= 2007 |pmid= 17229666 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CD34... {November 7, 2007 12:43:20 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:43:49 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = CD34 molecule
| HGNCid = 1662
| Symbol = CD34
| AltSymbols =;
| OMIM = 142230
| ECnumber =
| Homologene = 1343
| MGIid = 88329
| GeneAtlas_image1 = PBB_GE_CD34_209543_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030246 |text = carbohydrate binding}}
| Component = {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0016337 |text = cell-cell adhesion}} {{GNF_GO|id=GO:0050900 |text = leukocyte migration}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 947
| Hs_Ensembl = ENSG00000174059
| Hs_RefseqProtein = NP_001020280
| Hs_RefseqmRNA = NM_001025109
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 206116942
| Hs_GenLoc_end = 206151370
| Hs_Uniprot = P28906
| Mm_EntrezGene = 12490
| Mm_Ensembl = ENSMUSG00000016494
| Mm_RefseqmRNA = NM_133654
| Mm_RefseqProtein = NP_598415
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 196639610
| Mm_GenLoc_end = 196662005
| Mm_Uniprot = Q3TJP6
}}
}}
'''CD34 molecule''', also known as '''CD34''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = CD34 is a monomeric cell surface antigen with a molecular mass of approximately 110 kD that is selectively expressed on human hematopoietic progenitor cells.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: CD34 CD34 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=947| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ECGF1... {November 7, 2007 12:43:49 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ECGF1 image.jpg {November 7, 2007 12:44:40 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:44:58 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ECGF1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1uou.
| PDB = {{PDB2|1uou}}, {{PDB2|2j0f}}
| Name = Endothelial cell growth factor 1 (platelet-derived)
| HGNCid = 3148
| Symbol = ECGF1
| AltSymbols =; MNGIE; PDECGF; TP; hPD-ECGF
| OMIM = 131222
| ECnumber =
| Homologene = 1474
| MGIid = 1920212
| GeneAtlas_image1 = PBB_GE_ECGF1_204858_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ECGF1_205241_at_tn.png
| Function = {{GNF_GO|id=GO:0005161 |text = platelet-derived growth factor receptor binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}} {{GNF_GO|id=GO:0009032 |text = thymidine phosphorylase activity}} {{GNF_GO|id=GO:0016757 |text = transferase activity, transferring glycosyl groups}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0000002 |text = mitochondrial genome maintenance}} {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0006206 |text = pyrimidine base metabolic process}} {{GNF_GO|id=GO:0006220 |text = pyrimidine nucleotide metabolic process}} {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1890
| Hs_Ensembl = ENSG00000025708
| Hs_RefseqProtein = NP_001944
| Hs_RefseqmRNA = NM_001953
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 22
| Hs_GenLoc_start = 49311047
| Hs_GenLoc_end = 49315321
| Hs_Uniprot = P19971
| Mm_EntrezGene = 72962
| Mm_Ensembl = ENSMUSG00000022615
| Mm_RefseqmRNA = NM_138302
| Mm_RefseqProtein = NP_612175
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 89199698
| Mm_GenLoc_end = 89204806
| Mm_Uniprot = Q99N42
}}
}}
'''Endothelial cell growth factor 1 (platelet-derived)''', also known as '''ECGF1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Platelet-derived endothelial cell growth factor (ECGF1) is an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. ECGF1 has a highly restricted target cell specificity acting only on endothelial cells. Because it limits glial cell proliferation, ECGF1 is also known as thymidine phosphorylase and as gliostatin. The ECGF1 gene contains 10 exons spanning more than 4.3 kb. Thymidine phosphorylase activity of ECGF1 in leukocytes from mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) patients was less than 5 percent of controls, indicating that loss-of-function mutations in thymidine phosphorylase cause MNGIE.<ref>{{cite web | title = Entrez Gene: ECGF1 endothelial cell growth factor 1 (platelet-derived)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1890| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Yang Q, Yoshimura G, Mori I, ''et al.'' |title=Thymidine phosphorylase and breast carcinoma. |journal=Anticancer Res. |volume=22 |issue= 4 |pages= 2355-60 |year= 2002 |pmid= 12174926 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on EIF4G1... {November 7, 2007 12:44:58 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein EIF4G1 image.jpg {November 7, 2007 12:45:51 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:46:07 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_EIF4G1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ug3.
| PDB = {{PDB2|1ug3}}
| Name = Eukaryotic translation initiation factor 4 gamma, 1
| HGNCid = 3296
| Symbol = EIF4G1
| AltSymbols =; EIF4F; DKFZp686A1451; EIF4G; p220
| OMIM = 600495
| ECnumber =
| Homologene = 28096
| MGIid = 2384784
| GeneAtlas_image1 = PBB_GE_EIF4G1_208624_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_EIF4G1_208625_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0003743 |text = translation initiation factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0016281 |text = eukaryotic translation initiation factor 4F complex}}
| Process = {{GNF_GO|id=GO:0006446 |text = regulation of translational initiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1981
| Hs_Ensembl = ENSG00000114867
| Hs_RefseqProtein = NP_004944
| Hs_RefseqmRNA = NM_004953
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 185515033
| Hs_GenLoc_end = 185535839
| Hs_Uniprot = Q04637
| Mm_EntrezGene = 208643
| Mm_Ensembl = ENSMUSG00000045983
| Mm_RefseqmRNA = NM_001005331
| Mm_RefseqProtein = NP_001005331
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 20586292
| Mm_GenLoc_end = 20606426
| Mm_Uniprot = Q3UTK0
}}
}}
'''Eukaryotic translation initiation factor 4 gamma, 1''', also known as '''EIF4G1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a component of the protein complex EIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure, and recruitment of mRNA to the ribosome. Alternative splicing results in five transcript variants encoding four distinct isoforms.<ref>{{cite web | title = Entrez Gene: EIF4G1 eukaryotic translation initiation factor 4 gamma, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1981| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Gingras AC, Raught B, Sonenberg N |title=eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. |journal=Annu. Rev. Biochem. |volume=68 |issue= |pages= 913-63 |year= 2000 |pmid= 10872469 |doi= 10.1146/annurev.biochem.68.1.913 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on EPB41... {November 7, 2007 12:46:07 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein EPB41 image.jpg {November 7, 2007 12:47:22 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:47:36 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_EPB41_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gg3.
| PDB = {{PDB2|1gg3}}
| Name = Erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
| HGNCid = 3377
| Symbol = EPB41
| AltSymbols =; 4.1R; EL1; HE
| OMIM = 130500
| ECnumber =
| Homologene = 44324
| MGIid = 95401
| GeneAtlas_image1 = PBB_GE_EPB41_207793_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_EPB41_214530_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_EPB41_gnf1h06881_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005200 |text = structural constituent of cytoskeleton}} {{GNF_GO|id=GO:0005488 |text = binding}} {{GNF_GO|id=GO:0005545 |text = phosphatidylinositol binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0008091 |text = spectrin}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0030863 |text = cortical cytoskeleton}} {{GNF_GO|id=GO:0043234 |text = protein complex}}
| Process = {{GNF_GO|id=GO:0008015 |text = circulation}} {{GNF_GO|id=GO:0030866 |text = cortical actin cytoskeleton organization and biogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2035
| Hs_Ensembl = ENSG00000159023
| Hs_RefseqProtein = NP_004428
| Hs_RefseqmRNA = NM_004437
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 29086215
| Hs_GenLoc_end = 29319545
| Hs_Uniprot = P11171
| Mm_EntrezGene = 269587
| Mm_Ensembl = ENSMUSG00000028906
| Mm_RefseqmRNA = NM_183428
| Mm_RefseqProtein = NP_906273
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 131195505
| Mm_GenLoc_end = 131347350
| Mm_Uniprot = Q3U0G7
}}
}}
'''Erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)''', also known as '''EPB41''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Elliptocytosis is a hematologic disorder characterized by elliptically shaped erythrocytes and a variable degree of hemolytic anemia. Inherited as an autosomal dominant, elliptocytosis results from mutation in any one of several genes encoding proteins of the red cell membrane skeleton. The form discussed here is the one found in the 1950s to be linked to Rh blood group and more recently shown to be caused by a defect in protein 4.1. 'Rh-unlinked' forms of elliptocytosis are caused by mutation in the alpha-spectrin gene (MIM 182860), the beta-spectrin gene (MIM 182870), or the band 3 gene (MIM 109270).[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: EPB41 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2035| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Conboy JG |title=Structure, function, and molecular genetics of erythroid membrane skeletal protein 4.1 in normal and abnormal red blood cells. |journal=Semin. Hematol. |volume=30 |issue= 1 |pages= 58-73 |year= 1993 |pmid= 8434260 |doi= }}
*{{cite journal | author=Calinisan V, Gravem D, Chen RP, ''et al.'' |title=New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium. |journal=Front. Biosci. |volume=11 |issue= |pages= 1646-66 |year= 2006 |pmid= 16368544 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on IRAK1... {November 7, 2007 12:47:36 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:48:15 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
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| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Interleukin-1 receptor-associated kinase 1
| HGNCid = 6112
| Symbol = IRAK1
| AltSymbols =; IRAK; pelle
| OMIM = 300283
| ECnumber =
| Homologene = 37496
| MGIid = 107420
| GeneAtlas_image1 = PBB_GE_IRAK1_201587_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004672 |text = protein kinase activity}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004704 |text = NF-kappaB-inducing kinase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005149 |text = interleukin-1 receptor binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0019901 |text = protein kinase binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}}
| Component = {{GNF_GO|id=GO:0045323 |text = interleukin-1 receptor complex}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007178 |text = transmembrane receptor protein serine/threonine kinase signaling pathway}} {{GNF_GO|id=GO:0007250 |text = activation of NF-kappaB-inducing kinase}} {{GNF_GO|id=GO:0019221 |text = cytokine and chemokine mediated signaling pathway}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}} {{GNF_GO|id=GO:0046777 |text = protein amino acid autophosphorylation}} {{GNF_GO|id=GO:0051259 |text = protein oligomerization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3654
| Hs_Ensembl = ENSG00000184216
| Hs_RefseqProtein = NP_001020413
| Hs_RefseqmRNA = NM_001025242
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 152929145
| Hs_GenLoc_end = 152938625
| Hs_Uniprot = P51617
| Mm_EntrezGene = 16179
| Mm_Ensembl = ENSMUSG00000031392
| Mm_RefseqmRNA = NM_008363
| Mm_RefseqProtein = NP_032389
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 70266646
| Mm_GenLoc_end = 70276641
| Mm_Uniprot = Q8K4N7
}}
}}
'''Interleukin-1 receptor-associated kinase 1''', also known as '''IRAK1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: IRAK1 interleukin-1 receptor-associated kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3654| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Auron PE |title=The interleukin 1 receptor: ligand interactions and signal transduction. |journal=Cytokine Growth Factor Rev. |volume=9 |issue= 3-4 |pages= 221-37 |year= 1999 |pmid= 9918122 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on JAK3... {November 7, 2007 12:48:15 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein JAK3 image.jpg {November 7, 2007 12:48:31 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:48:49 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_JAK3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1yvj.
| PDB = {{PDB2|1yvj}}
| Name = Janus kinase 3 (a protein tyrosine kinase, leukocyte)
| HGNCid = 6193
| Symbol = JAK3
| AltSymbols =; JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK
| OMIM = 600173
| ECnumber =
| Homologene = 181
| MGIid = 99928
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0004718 |text = Janus kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005856 |text = cytoskeleton}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007498 |text = mesoderm development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3718
| Hs_Ensembl =
| Hs_RefseqProtein = NP_000206
| Hs_RefseqmRNA = NM_000215
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 16453
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_010589
| Mm_RefseqProtein = NP_034719
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Janus kinase 3 (a protein tyrosine kinase, leukocyte)''', also known as '''JAK3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = JAK3 encodes Janus kinase 3, a tyrosine kinase that belongs to the Janus family. JAK3 functions in signal transduction and interacts with members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations that abrogate Janus kinase 3 function cause an autosomal SCID (severe combined immunodeficiency disease).<ref>{{cite web | title = Entrez Gene: JAK3 Janus kinase 3 (a protein tyrosine kinase, leukocyte)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3718| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Notarangelo LD, Mella P, Jones A, ''et al.'' |title=Mutations in severe combined immune deficiency (SCID) due to JAK3 deficiency. |journal=Hum. Mutat. |volume=18 |issue= 4 |pages= 255-63 |year= 2002 |pmid= 11668610 |doi= 10.1002/humu.1188 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MC4R... {November 7, 2007 12:48:49 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 12:49:20 AM PST}
- CREATED: Created new protein page: MC4R {November 7, 2007 12:49:26 AM PST}
- INFO: Beginning work on NFE2L2... {November 7, 2007 12:49:26 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 12:50:09 AM PST}
- CREATED: Created new protein page: NFE2L2 {November 7, 2007 12:50:17 AM PST}
- INFO: Beginning work on NR0B1... {November 7, 2007 12:40:40 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:41:50 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Nuclear receptor subfamily 0, group B, member 1
| HGNCid = 7960
| Symbol = NR0B1
| AltSymbols =; AHC; AHCH; AHX; DAX-1; DAX1; DSS; GTD; HHG; NROB1
| OMIM = 300473
| ECnumber =
| Homologene = 403
| MGIid = 1352460
| GeneAtlas_image1 = PBB_GE_NR0B1_206644_at_tn.png
| GeneAtlas_image2 = PBB_GE_NR0B1_206645_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003706 |text = ligand-regulated transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}} {{GNF_GO|id=GO:0017163 |text = negative regulator of basal transcription activity}} {{GNF_GO|id=GO:0032448 |text = DNA hairpin binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0042788 |text = polysomal ribosome}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006694 |text = steroid biosynthetic process}} {{GNF_GO|id=GO:0008406 |text = gonad development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0030238 |text = male sex determination}} {{GNF_GO|id=GO:0030325 |text = adrenal gland development}} {{GNF_GO|id=GO:0045892 |text = negative regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 190
| Hs_Ensembl = ENSG00000169297
| Hs_RefseqProtein = NP_000466
| Hs_RefseqmRNA = NM_000475
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 30232244
| Hs_GenLoc_end = 30237636
| Hs_Uniprot = P51843
| Mm_EntrezGene = 11614
| Mm_Ensembl = ENSMUSG00000025056
| Mm_RefseqmRNA = NM_007430
| Mm_RefseqProtein = NP_031456
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 82444494
| Mm_GenLoc_end = 82448663
| Mm_Uniprot = Q53ZY9
}}
}}
'''Nuclear receptor subfamily 0, group B, member 1''', also known as '''NR0B1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.<ref>{{cite web | title = Entrez Gene: NR0B1 nuclear receptor subfamily 0, group B, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=190| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Goodfellow PN, Camerino G |title=DAX-1, an 'antitestis' gene. |journal=Cell. Mol. Life Sci. |volume=55 |issue= 6-7 |pages= 857-63 |year= 1999 |pmid= 10412368 |doi= }}
*{{cite journal | author=Achermann JC, Meeks JJ, Jameson JL |title=Phenotypic spectrum of mutations in DAX-1 and SF-1. |journal=Mol. Cell. Endocrinol. |volume=185 |issue= 1-2 |pages= 17-25 |year= 2003 |pmid= 11738790 |doi= }}
*{{cite journal | author=Franzese A, Brunetti-Pierri N, Spagnuolo MI, ''et al.'' |title=Inappropriate tall stature and renal ectopy in a male patient with X-linked congenital adrenal hypoplasia due to a novel missense mutation in the DAX-1 gene. |journal=Am. J. Med. Genet. A |volume=135 |issue= 1 |pages= 72-4 |year= 2005 |pmid= 15800903 |doi= 10.1002/ajmg.a.30670 }}
*{{cite journal | author=Achermann JC |title=The role of SF1/DAX1 in adrenal and reproductive function. |journal=Ann. Endocrinol. (Paris) |volume=66 |issue= 3 |pages= 233-9 |year= 2005 |pmid= 15988384 |doi= }}
*{{cite journal | author=Niakan KK, McCabe ER |title=DAX1 origin, function, and novel role. |journal=Mol. Genet. Metab. |volume=86 |issue= 1-2 |pages= 70-83 |year= 2006 |pmid= 16146703 |doi= 10.1016/j.ymgme.2005.07.019 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on POLR2G... {November 7, 2007 12:52:03 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein POLR2G image.jpg {November 7, 2007 12:52:36 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 12:52:54 AM PST}
- CREATED: Created new protein page: POLR2G {November 7, 2007 12:53:03 AM PST}
- INFO: Beginning work on POLR2H... {November 7, 2007 12:53:03 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein POLR2H image.jpg {November 7, 2007 12:53:55 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 12:54:10 AM PST}
- CREATED: Created new protein page: POLR2H {November 7, 2007 12:54:17 AM PST}
- INFO: Beginning work on PPARD... {November 7, 2007 12:54:17 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PPARD image.jpg {November 7, 2007 12:55:26 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:55:48 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PPARD_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gwx.
| PDB = {{PDB2|1gwx}}, {{PDB2|1y0s}}, {{PDB2|2awh}}, {{PDB2|2b50}}, {{PDB2|2baw}}, {{PDB2|2gwx}}, {{PDB2|2j14}}, {{PDB2|3gwx}}
| Name = Peroxisome proliferator-activated receptor delta
| HGNCid = 9235
| Symbol = PPARD
| AltSymbols =; FAAR; MGC3931; NR1C2; NUC1; NUCI; NUCII; PPAR-beta; PPARB
| OMIM = 600409
| ECnumber =
| Homologene = 4544
| MGIid = 101884
| GeneAtlas_image1 = PBB_GE_PPARD_37152_at_tn.png
| GeneAtlas_image2 = PBB_GE_PPARD_208044_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_PPARD_210636_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0005504 |text = fatty acid binding}} {{GNF_GO|id=GO:0008047 |text = enzyme activator activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016501 |text = prostacyclin receptor activity}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0046965 |text = retinoid X receptor binding}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006006 |text = glucose metabolic process}} {{GNF_GO|id=GO:0006091 |text = generation of precursor metabolites and energy}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006635 |text = fatty acid beta-oxidation}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007566 |text = embryo implantation}} {{GNF_GO|id=GO:0008203 |text = cholesterol metabolic process}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008366 |text = axon ensheathment}} {{GNF_GO|id=GO:0008544 |text = epidermis development}} {{GNF_GO|id=GO:0009062 |text = fatty acid catabolic process}} {{GNF_GO|id=GO:0014068 |text = positive regulation of phosphoinositide 3-kinase cascade}} {{GNF_GO|id=GO:0015758 |text = glucose transport}} {{GNF_GO|id=GO:0015908 |text = fatty acid transport}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0042640 |text = anagen}} {{GNF_GO|id=GO:0045600 |text = positive regulation of fat cell differentiation}} {{GNF_GO|id=GO:0046697 |text = decidualization}} {{GNF_GO|id=GO:0050796 |text = regulation of insulin secretion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5467
| Hs_Ensembl = ENSG00000112033
| Hs_RefseqProtein = NP_006229
| Hs_RefseqmRNA = NM_006238
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 35418320
| Hs_GenLoc_end = 35503933
| Hs_Uniprot = Q03181
| Mm_EntrezGene = 19015
| Mm_Ensembl = ENSMUSG00000002250
| Mm_RefseqmRNA = XM_990965
| Mm_RefseqProtein = XP_996059
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 27960392
| Mm_GenLoc_end = 28029058
| Mm_Uniprot = Q546I3
}}
}}
'''Peroxisome proliferator-activated receptor delta''', also known as '''PPARD''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.<ref>{{cite web | title = Entrez Gene: PPARD peroxisome proliferator-activated receptor delta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5467| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kersten S, Desvergne B, Wahli W |title=Roles of PPARs in health and disease. |journal=Nature |volume=405 |issue= 6785 |pages= 421-4 |year= 2000 |pmid= 10839530 |doi= 10.1038/35013000 }}
*{{cite journal | author=Bastie C |title=[PPARdelta and PPARgamma: roles in fatty acids signalling, implication in tumorigenesis] |journal=Bulletin du cancer |volume=89 |issue= 1 |pages= 23-8 |year= 2002 |pmid= 11847022 |doi= }}
*{{cite journal | author=Fredenrich A, Grimaldi PA |title=Roles of peroxisome proliferator-activated receptor delta in skeletal muscle function and adaptation. |journal=Current opinion in clinical nutrition and metabolic care |volume=7 |issue= 4 |pages= 377-81 |year= 2004 |pmid= 15192438 |doi= }}
*{{cite journal | author=Fredenrich A, Grimaldi PA |title=PPAR delta: an uncompletely known nuclear receptor. |journal=Diabetes Metab. |volume=31 |issue= 1 |pages= 23-7 |year= 2005 |pmid= 15803109 |doi= }}
*{{cite journal | author=Barish GD, Narkar VA, Evans RM |title=PPAR delta: a dagger in the heart of the metabolic syndrome. |journal=J. Clin. Invest. |volume=116 |issue= 3 |pages= 590-7 |year= 2006 |pmid= 16511591 |doi= 10.1172/JCI27955 }}
*{{cite journal | author=Fürnsinn C, Willson TM, Brunmair B |title=Peroxisome proliferator-activated receptor-delta, a regulator of oxidative capacity, fuel switching and cholesterol transport. |journal=Diabetologia |volume=50 |issue= 1 |pages= 8-17 |year= 2007 |pmid= 17119917 |doi= 10.1007/s00125-006-0492-0 }}
*{{cite journal | author=Takahashi S, Tanaka T, Sakai J |title=New therapeutic target for metabolic syndrome: PPARdelta. |journal=Endocr. J. |volume=54 |issue= 3 |pages= 347-57 |year= 2007 |pmid= 17409576 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on REN... {November 7, 2007 12:55:48 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein REN image.jpg {November 7, 2007 12:56:20 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:56:31 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_REN_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bbs.
| PDB = {{PDB2|1bbs}}, {{PDB2|1bil}}, {{PDB2|1bim}}, {{PDB2|1hrn}}, {{PDB2|1rne}}, {{PDB2|2bks}}, {{PDB2|2bkt}}, {{PDB2|2fs4}}, {{PDB2|2g1n}}, {{PDB2|2g1o}}, {{PDB2|2g1r}}, {{PDB2|2g1s}}, {{PDB2|2g1y}}, {{PDB2|2g20}}, {{PDB2|2g21}}, {{PDB2|2g22}}, {{PDB2|2g24}}, {{PDB2|2g26}}, {{PDB2|2g27}}, {{PDB2|2i4q}}, {{PDB2|2iko}}, {{PDB2|2iku}}, {{PDB2|2il2}}, {{PDB2|2ren}}
| Name = Renin
| HGNCid = 9958
| Symbol = REN
| AltSymbols =; FLJ10761
| OMIM = 179820
| ECnumber =
| Homologene = 20151
| MGIid = 97898
| GeneAtlas_image1 = PBB_GE_REN_206367_at_tn.png
| Function = {{GNF_GO|id=GO:0004194 |text = pepsin A activity}} {{GNF_GO|id=GO:0004195 |text = renin activity}} {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0008233 |text = peptidase activity}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0002003 |text = angiotensin maturation}} {{GNF_GO|id=GO:0002016 |text = renin-angiotensin regulation of body fluid levels}} {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0008217 |text = blood pressure regulation}} {{GNF_GO|id=GO:0009755 |text = hormone-mediated signaling}} {{GNF_GO|id=GO:0042756 |text = drinking behavior}} {{GNF_GO|id=GO:0043408 |text = regulation of MAPKKK cascade}} {{GNF_GO|id=GO:0048469 |text = cell maturation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5972
| Hs_Ensembl = ENSG00000143839
| Hs_RefseqProtein = NP_000528
| Hs_RefseqmRNA = NM_000537
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 202390570
| Hs_GenLoc_end = 202402088
| Hs_Uniprot = P00797
| Mm_EntrezGene = 19701
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_031192
| Mm_RefseqProtein = NP_112469
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Renin''', also known as '''REN''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.<ref>{{cite web | title = Entrez Gene: REN renin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5972| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Morris BJ |title=New possibilities for intracellular renin and inactive renin now that the structure of the human renin gene has been elucidated. |journal=Clin. Sci. |volume=71 |issue= 4 |pages= 345-55 |year= 1986 |pmid= 3530608 |doi= }}
*{{cite journal | author=Tamura K, Umemura S, Fukamizu A, ''et al.'' |title=Recent advances in the study of renin and angiotensinogen genes: from molecules to the whole body. |journal=Hypertens. Res. |volume=18 |issue= 1 |pages= 7-18 |year= 1995 |pmid= 7584914 |doi= }}
*{{cite journal | author=Padmanabhan N, Padmanabhan S, Connell JM |title=Genetic basis of cardiovascular disease--the renin-angiotensin-aldosterone system as a paradigm. |journal=Journal of the renin-angiotensin-aldosterone system : JRAAS |volume=1 |issue= 4 |pages= 316-24 |year= 2002 |pmid= 11967817 |doi= 10.3317/jraas.2000.060 }}
*{{cite journal | author=Varagic J, Frohlich ED |title=Local cardiac renin-angiotensin system: hypertension and cardiac failure. |journal=J. Mol. Cell. Cardiol. |volume=34 |issue= 11 |pages= 1435-42 |year= 2003 |pmid= 12431442 |doi= }}
*{{cite journal | author=Jan Danser AH, Saris JJ |title=Prorenin uptake in the heart: a prerequisite for local angiotensin generation? |journal=J. Mol. Cell. Cardiol. |volume=34 |issue= 11 |pages= 1463-72 |year= 2003 |pmid= 12431445 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SAA1... {November 7, 2007 12:56:31 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:57:24 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Serum amyloid A1
| HGNCid = 10513
| Symbol = SAA1
| AltSymbols =; SAA; MGC111216; PIG4; TP53I4
| OMIM = 104750
| ECnumber =
| Homologene = 69088
| MGIid = 98221
| GeneAtlas_image1 = PBB_GE_SAA1_208607_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SAA1_214456_x_at_tn.png
| Function = {{GNF_GO|id=GO:0001664 |text = G-protein-coupled receptor binding}} {{GNF_GO|id=GO:0005319 |text = lipid transporter activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006953 |text = acute-phase response}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}} {{GNF_GO|id=GO:0030168 |text = platelet activation}} {{GNF_GO|id=GO:0030593 |text = neutrophil chemotaxis}} {{GNF_GO|id=GO:0045785 |text = positive regulation of cell adhesion}} {{GNF_GO|id=GO:0048246 |text = macrophage chemotaxis}} {{GNF_GO|id=GO:0048247 |text = lymphocyte chemotaxis}} {{GNF_GO|id=GO:0050708 |text = regulation of protein secretion}} {{GNF_GO|id=GO:0050716 |text = positive regulation of interleukin-1 secretion}} {{GNF_GO|id=GO:0050728 |text = negative regulation of inflammatory response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6288
| Hs_Ensembl = ENSG00000173432
| Hs_RefseqProtein = NP_000322
| Hs_RefseqmRNA = NM_000331
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 18244346
| Hs_GenLoc_end = 18248088
| Hs_Uniprot = P02735
| Mm_EntrezGene = 20208
| Mm_Ensembl = ENSMUSG00000074115
| Mm_RefseqmRNA = NM_009117
| Mm_RefseqProtein = NP_033143
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 46608540
| Mm_GenLoc_end = 46611022
| Mm_Uniprot = Q64454
}}
}}
'''Serum amyloid A1''', also known as '''SAA1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kisilevsky R, Tam SP |title=Acute phase serum amyloid A, cholesterol metabolism, and cardiovascular disease. |journal=Pediatric pathology & molecular medicine |volume=21 |issue= 3 |pages= 291-305 |year= 2002 |pmid= 12056504 |doi= 10.1080/02770930290056523 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SELPLG... {November 7, 2007 12:57:24 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:58:24 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Selectin P ligand
| HGNCid = 10722
| Symbol = SELPLG
| AltSymbols =; CD162; CLA; PSGL-1; PSGL1
| OMIM = 600738
| ECnumber =
| Homologene = 2261
| MGIid = 106689
| GeneAtlas_image1 = PBB_GE_SELPLG_209879_at_tn.png
| GeneAtlas_image2 = PBB_GE_SELPLG_209880_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0005529 |text = sugar binding}} {{GNF_GO|id=GO:0008367 |text = bacterial binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6404
| Hs_Ensembl = ENSG00000110876
| Hs_RefseqProtein = NP_002997
| Hs_RefseqmRNA = NM_003006
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 107540974
| Hs_GenLoc_end = 107542212
| Hs_Uniprot = Q14242
| Mm_EntrezGene = 20345
| Mm_Ensembl = ENSMUSG00000048163
| Mm_RefseqmRNA = NM_009151
| Mm_RefseqProtein = NP_033177
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 114079535
| Mm_GenLoc_end = 114091474
| Mm_Uniprot = Q99L34
}}
}}
'''Selectin P ligand''', also known as '''SELPLG''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = SELPLG is the high affinity counter-receptor for P-selectin on myeloid cells and stimulated T lymphocytes. As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. The organization of the SELPG gene closely resembles that of CD43 and the human platelet glycoprotein GpIb-alpha both of which have an intron in the 5-prime-noncoding region, a long second exon containing the complete coding region, and TATA-less promoters.<ref>{{cite web | title = Entrez Gene: SELPLG selectin P ligand| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6404| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Furie B, Furie BC |title=Role of platelet P-selectin and microparticle PSGL-1 in thrombus formation. |journal=Trends in molecular medicine |volume=10 |issue= 4 |pages= 171-8 |year= 2004 |pmid= 15059608 |doi= 10.1016/j.molmed.2004.02.008 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SERPINB5... {November 7, 2007 12:51:15 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SERPINB5 image.jpg {November 7, 2007 12:51:50 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:52:03 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SERPINB5_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wz9.
| PDB = {{PDB2|1wz9}}, {{PDB2|1xqg}}, {{PDB2|1xqj}}, {{PDB2|1xu8}}
| Name = Serpin peptidase inhibitor, clade B (ovalbumin), member 5
| HGNCid = 8949
| Symbol = SERPINB5
| AltSymbols =; PI5; maspin
| OMIM = 154790
| ECnumber =
| Homologene = 20580
| MGIid = 109579
| GeneAtlas_image1 = PBB_GE_SERPINB5_204855_at_tn.png
| Function = {{GNF_GO|id=GO:0004867 |text = serine-type endopeptidase inhibitor activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006928 |text = cell motility}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5268
| Hs_Ensembl = ENSG00000206075
| Hs_RefseqProtein = NP_002630
| Hs_RefseqmRNA = NM_002639
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 18
| Hs_GenLoc_start = 59295199
| Hs_GenLoc_end = 59323297
| Hs_Uniprot = P36952
| Mm_EntrezGene = 20724
| Mm_Ensembl = ENSMUSG00000067006
| Mm_RefseqmRNA = NM_009257
| Mm_RefseqProtein = NP_033283
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 108688727
| Mm_GenLoc_end = 108710895
| Mm_Uniprot = Q3ULZ0
}}
}}
'''Serpin peptidase inhibitor, clade B (ovalbumin), member 5''', also known as '''SERPINB5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Sager R, Sheng S, Pemberton P, Hendrix MJ |title=Maspin. A tumor suppressing serpin. |journal=Adv. Exp. Med. Biol. |volume=425 |issue= |pages= 77-88 |year= 1998 |pmid= 9433491 |doi= }}
*{{cite journal | author=Sheng S |title=The promise and challenge toward the clinical application of maspin in cancer. |journal=Front. Biosci. |volume=9 |issue= |pages= 2733-45 |year= 2006 |pmid= 15353310 |doi= }}
*{{cite journal | author=Lockett J, Yin S, Li X, ''et al.'' |title=Tumor suppressive maspin and epithelial homeostasis. |journal=J. Cell. Biochem. |volume=97 |issue= 4 |pages= 651-60 |year= 2006 |pmid= 16329135 |doi= 10.1002/jcb.20721 }}
*{{cite journal | author=Chen EI, Yates JR |title=Maspin and tumor metastasis. |journal=IUBMB Life |volume=58 |issue= 1 |pages= 25-9 |year= 2006 |pmid= 16540429 |doi= 10.1080/15216540500531721 }}
*{{cite journal | author=Khalkhali-Ellis Z |title=Maspin: the new frontier. |journal=Clin. Cancer Res. |volume=12 |issue= 24 |pages= 7279-83 |year= 2007 |pmid= 17189399 |doi= 10.1158/1078-0432.CCR-06-1589 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SERPING1... {November 7, 2007 12:42:30 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SERPING1 image.jpg {November 7, 2007 12:43:01 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:43:20 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SERPING1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2oay.
| PDB = {{PDB2|2oay}}
| Name = Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)
| HGNCid = 1228
| Symbol = SERPING1
| AltSymbols =; C1IN; C1INH; C1NH; HAE1; HAE2
| OMIM = 606860
| ECnumber =
| Homologene = 44
| MGIid = 894696
| GeneAtlas_image1 = PBB_GE_SERPING1_200986_at_tn.png
| Function = {{GNF_GO|id=GO:0004867 |text = serine-type endopeptidase inhibitor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006958 |text = complement activation, classical pathway}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}} {{GNF_GO|id=GO:0008015 |text = circulation}} {{GNF_GO|id=GO:0045087 |text = innate immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 710
| Hs_Ensembl = ENSG00000149131
| Hs_RefseqProtein = NP_000053
| Hs_RefseqmRNA = NM_000062
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 57121603
| Hs_GenLoc_end = 57138902
| Hs_Uniprot = P05155
| Mm_EntrezGene = 12258
| Mm_Ensembl = ENSMUSG00000023224
| Mm_RefseqmRNA = NM_009776
| Mm_RefseqProtein = NP_033906
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 84566224
| Mm_GenLoc_end = 84576243
| Mm_Uniprot = P97290
}}
}}
'''Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)''', also known as '''SERPING1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform.<ref>{{cite web | title = Entrez Gene: SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=710| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Lappin D, Whaley K |title=Regulation of C1-inhibitor synthesis by interferons and other agents. |journal=Behring Inst. Mitt. |volume= |issue= 84 |pages= 180-92 |year= 1989 |pmid= 2478116 |doi= }}
*{{cite journal | author=Stein PE, Carrell RW |title=What do dysfunctional serpins tell us about molecular mobility and disease? |journal=Nat. Struct. Biol. |volume=2 |issue= 2 |pages= 96-113 |year= 1995 |pmid= 7749926 |doi= }}
*{{cite journal | author=Davis AE, Bissler JJ, Cicardi M |title=Mutations in the C1 inhibitor gene that result in hereditary angioneurotic edema. |journal=Behring Inst. Mitt. |volume= |issue= 93 |pages= 313-20 |year= 1994 |pmid= 8172583 |doi= }}
*{{cite journal | author=Davis AE |title=The pathophysiology of hereditary angioedema. |journal=Clin. Immunol. |volume=114 |issue= 1 |pages= 3-9 |year= 2005 |pmid= 15596403 |doi= 10.1016/j.clim.2004.05.007 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SNAP25... {November 7, 2007 12:58:24 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SNAP25 image.jpg {November 7, 2007 12:59:12 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:59:36 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SNAP25_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1jth.
| PDB = {{PDB2|1jth}}, {{PDB2|1kil}}, {{PDB2|1n7s}}, {{PDB2|1sfc}}, {{PDB2|1urq}}, {{PDB2|1xtg}}
| Name = Synaptosomal-associated protein, 25kDa
| HGNCid = 11132
| Symbol = SNAP25
| AltSymbols =; FLJ23079; RIC-4; RIC4; SEC9; SNAP; SNAP-25; bA416N4.2; dJ1068F16.2
| OMIM = 600322
| ECnumber =
| Homologene = 13311
| MGIid = 98331
| GeneAtlas_image1 = PBB_GE_SNAP25_202508_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SNAP25_202507_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000149 |text = SNARE binding}}
| Component = {{GNF_GO|id=GO:0019717 |text = synaptosome}} {{GNF_GO|id=GO:0045202 |text = synapse}}
| Process = {{GNF_GO|id=GO:0001504 |text = neurotransmitter uptake}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007269 |text = neurotransmitter secretion}} {{GNF_GO|id=GO:0016081 |text = synaptic vesicle docking during exocytosis}} {{GNF_GO|id=GO:0050796 |text = regulation of insulin secretion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6616
| Hs_Ensembl = ENSG00000132639
| Hs_RefseqProtein = NP_003072
| Hs_RefseqmRNA = NM_003081
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 10147477
| Hs_GenLoc_end = 10236066
| Hs_Uniprot = P60880
| Mm_EntrezGene = 20614
| Mm_Ensembl = ENSMUSG00000027273
| Mm_RefseqmRNA = NM_011428
| Mm_RefseqProtein = NP_035558
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 136404894
| Mm_GenLoc_end = 136473860
| Mm_Uniprot = P60879
}}
}}
'''Synaptosomal-associated protein, 25kDa''', also known as '''SNAP25''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene.<ref>{{cite web | title = Entrez Gene: SNAP25 synaptosomal-associated protein, 25kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6616| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SQSTM1... {November 7, 2007 1:03:07 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SQSTM1 image.jpg {November 7, 2007 1:03:55 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:04:27 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SQSTM1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1q02.
| PDB = {{PDB2|1q02}}
| Name = Sequestosome 1
| HGNCid = 11280
| Symbol = SQSTM1
| AltSymbols =; p60; A170; OSIL; PDB3; ZIP3; p62; p62B
| OMIM = 601530
| ECnumber =
| Homologene = 31202
| MGIid = 107931
| GeneAtlas_image1 = PBB_GE_SQSTM1_201471_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SQSTM1_213112_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0019901 |text = protein kinase binding}} {{GNF_GO|id=GO:0030971 |text = receptor tyrosine kinase binding}} {{GNF_GO|id=GO:0042169 |text = SH2 domain binding}} {{GNF_GO|id=GO:0043130 |text = ubiquitin binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006950 |text = response to stress}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0008104 |text = protein localization}} {{GNF_GO|id=GO:0016197 |text = endosome transport}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0043122 |text = regulation of I-kappaB kinase/NF-kappaB cascade}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8878
| Hs_Ensembl = ENSG00000161011
| Hs_RefseqProtein = NP_003891
| Hs_RefseqmRNA = NM_003900
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 179180503
| Hs_GenLoc_end = 179196199
| Hs_Uniprot = Q13501
| Mm_EntrezGene = 18412
| Mm_Ensembl = ENSMUSG00000015837
| Mm_RefseqmRNA = NM_011018
| Mm_RefseqProtein = NP_035148
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 50043578
| Mm_GenLoc_end = 50054213
| Mm_Uniprot = Q64337
}}
}}
'''Sequestosome 1''', also known as '''SQSTM1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Geetha T, Wooten MW |title=Structure and functional properties of the ubiquitin binding protein p62. |journal=FEBS Lett. |volume=512 |issue= 1-3 |pages= 19-24 |year= 2002 |pmid= 11852044 |doi= }}
*{{cite journal | author=Layfield R, Ciani B, Ralston SH, ''et al.'' |title=Structural and functional studies of mutations affecting the UBA domain of SQSTM1 (p62) which cause Paget's disease of bone. |journal=Biochem. Soc. Trans. |volume=32 |issue= Pt 5 |pages= 728-30 |year= 2005 |pmid= 15493999 |doi= 10.1042/BST0320728 }}
*{{cite journal | author=Michou L, Collet C, Laplanche JL, ''et al.'' |title=Genetics of Paget's disease of bone. |journal=Joint Bone Spine |volume=73 |issue= 3 |pages= 243-8 |year= 2006 |pmid= 16574459 |doi= 10.1016/j.jbspin.2005.05.009 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TNNT2... {November 7, 2007 12:59:36 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TNNT2 image.jpg {November 7, 2007 1:00:06 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 1:00:21 AM PST}
- CREATED: Created new protein page: TNNT2 {November 7, 2007 1:00:27 AM PST}
- INFO: Beginning work on TUBB2A... {November 7, 2007 1:00:27 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TUBB2A image.jpg {November 7, 2007 1:02:19 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:02:33 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TUBB2A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ffx.
| PDB = {{PDB2|1ffx}}, {{PDB2|1ia0}}, {{PDB2|1jff}}, {{PDB2|1sa0}}, {{PDB2|1sa1}}, {{PDB2|1tub}}, {{PDB2|1tvk}}, {{PDB2|1z2b}}, {{PDB2|2hxf}}, {{PDB2|2hxh}}
| Name = Tubulin, beta 2A
| HGNCid = 12412
| Symbol = TUBB2A
| AltSymbols =; TUBB; TUBB2; dJ40E16.7
| OMIM =
| ECnumber =
| Homologene = 68156
| MGIid = 107861
| GeneAtlas_image1 = PBB_GE_TUBB2A_202154_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_TUBB2A_208977_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_TUBB2A_204141_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005200 |text = structural constituent of cytoskeleton}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005874 |text = microtubule}} {{GNF_GO|id=GO:0043234 |text = protein complex}}
| Process = {{GNF_GO|id=GO:0007018 |text = microtubule-based movement}} {{GNF_GO|id=GO:0051258 |text = protein polymerization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7280
| Hs_Ensembl = ENSG00000137267
| Hs_RefseqProtein = NP_001060
| Hs_RefseqmRNA = NM_001069
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 3098918
| Hs_GenLoc_end = 3102808
| Hs_Uniprot = Q13885
| Mm_EntrezGene = 22151
| Mm_Ensembl = ENSMUSG00000058672
| Mm_RefseqmRNA = NM_009450
| Mm_RefseqProtein = NP_033476
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 34081743
| Mm_GenLoc_end = 34085453
| Mm_Uniprot = Q62363
}}
}}
'''Tubulin, beta 2A''', also known as '''TUBB2A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on VEGFC... {November 7, 2007 1:02:33 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:03:07 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Vascular endothelial growth factor C
| HGNCid = 12682
| Symbol = VEGFC
| AltSymbols =; Flt4-L; VRP
| OMIM = 601528
| ECnumber =
| Homologene = 3962
| MGIid = 109124
| GeneAtlas_image1 = PBB_GE_VEGFC_209946_at_tn.png
| Function = {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0006929 |text = substrate-bound cell migration}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0016331 |text = morphogenesis of embryonic epithelium}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7424
| Hs_Ensembl = ENSG00000150630
| Hs_RefseqProtein = NP_005420
| Hs_RefseqmRNA = NM_005429
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 177841685
| Hs_GenLoc_end = 177950889
| Hs_Uniprot = P49767
| Mm_EntrezGene = 22341
| Mm_Ensembl = ENSMUSG00000031520
| Mm_RefseqmRNA = NM_009506
| Mm_RefseqProtein = NP_033532
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 55576304
| Mm_GenLoc_end = 55685794
| Mm_Uniprot = P97953
}}
}}
'''Vascular endothelial growth factor C''', also known as '''VEGFC''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D.<ref>{{cite web | title = Entrez Gene: VEGFC vascular endothelial growth factor C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7424| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Orpana A, Salven P |title=Angiogenic and lymphangiogenic molecules in hematological malignancies. |journal=Leuk. Lymphoma |volume=43 |issue= 2 |pages= 219-24 |year= 2003 |pmid= 11999550 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on YBX1... {November 7, 2007 12:50:17 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein YBX1 image.jpg {November 7, 2007 12:50:36 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:51:15 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_YBX1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1h95.
| PDB = {{PDB2|1h95}}
| Name = Y box binding protein 1
| HGNCid = 8014
| Symbol = YBX1
| AltSymbols =; BP-8; CSDA2; CSDB; DBPB; MDR-NF1; MGC104858; MGC110976; MGC117250; NSEP-1; NSEP1; YB-1; YB1
| OMIM = 154030
| ECnumber =
| Homologene = 88707
| MGIid =
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003690 |text = double-stranded DNA binding}} {{GNF_GO|id=GO:0003697 |text = single-stranded DNA binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4904
| Hs_Ensembl =
| Hs_RefseqProtein = NP_004550
| Hs_RefseqmRNA = NM_004559
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Y box binding protein 1''', also known as '''YBX1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
end log.
