- INFO: Beginning work on ADCYAP1R1... {November 24, 2007 2:25:55 PM PST}
- REDIRECT: Protein Redirected to: ADCYAP1R1 {November 24, 2007 2:26:27 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 24, 2007 2:26:33 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 24, 2007 2:26:33 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 24, 2007 2:26:33 PM PST}
- UPDATED: Updated protein page: ADCYAP1R1 {November 24, 2007 2:26:42 PM PST}
- INFO: Beginning work on ADORA1... {November 24, 2007 2:26:42 PM PST}
- REDIRECT: Protein Redirected to: ADORA1 {November 24, 2007 2:27:10 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 24, 2007 2:27:13 PM PST}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {November 24, 2007 2:27:13 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 24, 2007 2:27:13 PM PST}
- UPDATED: Updated protein page: ADORA1 {November 24, 2007 2:27:22 PM PST}
- INFO: Beginning work on ADORA2A... {November 24, 2007 2:27:22 PM PST}
- REDIRECT: Protein Redirected to: ADORA2A {November 24, 2007 2:27:49 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 24, 2007 2:27:54 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 24, 2007 2:27:54 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 24, 2007 2:27:54 PM PST}
- UPDATED: Updated protein page: ADORA2A {November 24, 2007 2:28:02 PM PST}
- INFO: Beginning work on ADORA2B... {November 24, 2007 2:28:02 PM PST}
- CREATE: Found no pages, creating new page. {November 24, 2007 2:29:14 PM PST}
- CREATED: Created new protein page: ADORA2B {November 24, 2007 2:29:30 PM PST}
- INFO: Beginning work on ADORA3... {November 24, 2007 2:29:30 PM PST}
- REDIRECT: Protein Redirected to: ADORA3 {November 24, 2007 2:30:04 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 24, 2007 2:30:07 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 24, 2007 2:30:07 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 24, 2007 2:30:07 PM PST}
- UPDATED: Updated protein page: ADORA3 {November 24, 2007 2:30:14 PM PST}
- INFO: Beginning work on ADRA1A... {November 24, 2007 2:32:20 PM PST}
- REDIRECT: Protein Redirected to: ADRA1A {November 24, 2007 2:32:58 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 24, 2007 2:33:01 PM PST}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {November 24, 2007 2:33:01 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 24, 2007 2:33:01 PM PST}
- UPDATED: Updated protein page: ADRA1A {November 24, 2007 2:33:12 PM PST}
- INFO: Beginning work on ADRA1B... {November 24, 2007 2:31:28 PM PST}
- SEARCH REDIRECT: Control Box Found: ADRA1B {November 24, 2007 2:32:06 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 24, 2007 2:32:09 PM PST}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {November 24, 2007 2:32:09 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 24, 2007 2:32:09 PM PST}
- UPDATED: Updated protein page: ADRA1B {November 24, 2007 2:32:20 PM PST}
- INFO: Beginning work on ADRA1D... {November 24, 2007 2:30:14 PM PST}
- SEARCH REDIRECT: Control Box Found: ADRA1D {November 24, 2007 2:31:17 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 24, 2007 2:31:20 PM PST}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {November 24, 2007 2:31:20 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 24, 2007 2:31:20 PM PST}
- UPDATED: Updated protein page: ADRA1D {November 24, 2007 2:31:28 PM PST}
- INFO: Beginning work on ADRA2A... {November 24, 2007 2:33:12 PM PST}
- SEARCH REDIRECT: Control Box Found: ADRA2A {November 24, 2007 2:33:59 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 24, 2007 2:34:00 PM PST}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {November 24, 2007 2:34:00 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 24, 2007 2:34:00 PM PST}
- UPDATED: Updated protein page: ADRA2A {November 24, 2007 2:34:09 PM PST}
- INFO: Beginning work on ADRA2B... {November 24, 2007 2:34:09 PM PST}
- SEARCH REDIRECT: Control Box Found: ADRA2B {November 24, 2007 2:34:41 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 24, 2007 2:34:44 PM PST}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {November 24, 2007 2:34:44 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 24, 2007 2:34:44 PM PST}
- UPDATED: Updated protein page: ADRA2B {November 24, 2007 2:34:53 PM PST}
- INFO: Beginning work on ADRA2C... {November 24, 2007 2:34:53 PM PST}
- SEARCH REDIRECT: Control Box Found: ADRA2C {November 24, 2007 2:35:18 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 24, 2007 2:35:19 PM PST}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {November 24, 2007 2:35:19 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 24, 2007 2:35:19 PM PST}
- UPDATED: Updated protein page: ADRA2C {November 24, 2007 2:35:25 PM PST}
- INFO: Beginning work on ADRB1... {November 24, 2007 2:35:25 PM PST}
- SEARCH REDIRECT: Control Box Found: ADRB1 {November 24, 2007 2:35:58 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 24, 2007 2:36:01 PM PST}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {November 24, 2007 2:36:01 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 24, 2007 2:36:01 PM PST}
- UPDATED: Updated protein page: ADRB1 {November 24, 2007 2:36:08 PM PST}
- INFO: Beginning work on ADRB2... {November 24, 2007 2:36:08 PM PST}
- REDIRECT: Protein Redirected to: ADRB2 {November 24, 2007 2:36:25 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 24, 2007 2:36:26 PM PST}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {November 24, 2007 2:36:26 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 24, 2007 2:36:26 PM PST}
- UPDATED: Updated protein page: ADRB2 {November 24, 2007 2:36:33 PM PST}
- INFO: Beginning work on ADRB3... {November 24, 2007 2:36:33 PM PST}
- SEARCH REDIRECT: Control Box Found: ADRB3 {November 24, 2007 2:36:55 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 24, 2007 2:36:58 PM PST}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {November 24, 2007 2:36:58 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 24, 2007 2:36:58 PM PST}
- UPDATED: Updated protein page: ADRB3 {November 24, 2007 2:37:06 PM PST}
- INFO: Beginning work on AGTR1... {November 24, 2007 2:37:06 PM PST}
- SEARCH REDIRECT: Control Box Found: AGTR1 {November 24, 2007 2:38:11 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 24, 2007 2:38:15 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 24, 2007 2:38:15 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 24, 2007 2:38:15 PM PST}
- UPDATED: Updated protein page: AGTR1 {November 24, 2007 2:38:22 PM PST}
- INFO: Beginning work on AGTR2... {November 24, 2007 2:38:22 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 24, 2007 2:38:56 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Angiotensin II receptor, type 2
| HGNCid = 338
| Symbol = AGTR2
| AltSymbols =; AT2; ATGR2; MRX88
| OMIM = 300034
| ECnumber =
| Homologene = 20172
| MGIid = 87966
| GeneAtlas_image1 = PBB_GE_AGTR2_207294_at_tn.png
| GeneAtlas_image2 = PBB_GE_AGTR2_207293_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_AGTR2_222321_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004860 |text = protein kinase inhibitor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004945 |text = angiotensin type II receptor activity}} {{GNF_GO|id=GO:0004947 |text = bradykinin receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0002033 |text = angiotensin mediated vasodilation during regulation of blood pressure}} {{GNF_GO|id=GO:0002035 |text = brain renin-angiotensin system}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007610 |text = behavior}} {{GNF_GO|id=GO:0008217 |text = blood pressure regulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 186
| Hs_Ensembl = ENSG00000180772
| Hs_RefseqProtein = NP_000677
| Hs_RefseqmRNA = NM_000686
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 115216003
| Hs_GenLoc_end = 115220253
| Hs_Uniprot = P50052
| Mm_EntrezGene = 11609
| Mm_Ensembl = ENSMUSG00000068122
| Mm_RefseqmRNA = NM_007429
| Mm_RefseqProtein = NP_031455
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 20641585
| Mm_GenLoc_end = 20646123
| Mm_Uniprot = Q3US12
}}
}}
'''Angiotensin II receptor, type 2''', also known as '''AGTR2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AGTR2 angiotensin II receptor, type 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=186| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Angiotensin II is a potent pressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors termed AT1 and AT2. AGTR2 belongs to a family 1 of G-protein coupled receptors. It is an intergral membrane protein. It plays a role in the central nervous system and cardiovascular functions that are mediated by the renin-angiotensin system. This receptor mediates programmed cell death (apoptosis). In adults, it is highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. It is highly expressed in fetal kidney and intestine. The human AGTR2 gene is composed of three exons and spans at least 5 kb. Exons 1 and 2 encode for 5' untranslated mRNA sequence and exon 3 harbors the entire uninterrupted open reading frame.<ref name="entrez">{{cite web | title = Entrez Gene: AGTR2 angiotensin II receptor, type 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=186| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Regitz-Zagrosek V, Neuss M, Warnecke C, ''et al.'' |title=Subtype 2 and atypical angiotensin receptors in the human heart. |journal=Basic Res. Cardiol. |volume=91 Suppl 2 |issue= |pages= 73-7 |year= 1997 |pmid= 8957548 |doi= }}
*{{cite journal | author=Berry C, Touyz R, Dominiczak AF, ''et al.'' |title=Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide. |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=281 |issue= 6 |pages= H2337-65 |year= 2002 |pmid= 11709400 |doi= }}
*{{cite journal | author=Takayanagi R, Ohnaka K, Sakai Y, ''et al.'' |title=Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor. |journal=Biochem. Biophys. Res. Commun. |volume=183 |issue= 2 |pages= 910-6 |year= 1992 |pmid= 1550596 |doi= }}
*{{cite journal | author=Hein L, Barsh GS, Pratt RE, ''et al.'' |title=Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice. |journal=Nature |volume=377 |issue= 6551 |pages= 744-7 |year= 1995 |pmid= 7477266 |doi= 10.1038/377744a0 }}
*{{cite journal | author=Ichiki T, Labosky PA, Shiota C, ''et al.'' |title=Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. |journal=Nature |volume=377 |issue= 6551 |pages= 748-50 |year= 1995 |pmid= 7477267 |doi= 10.1038/377748a0 }}
*{{cite journal | author=Lazard D, Briend-Sutren MM, Villageois P, ''et al.'' |title=Molecular characterization and chromosome localization of a human angiotensin II AT2 receptor gene highly expressed in fetal tissues. |journal=Recept. Channels |volume=2 |issue= 4 |pages= 271-80 |year= 1995 |pmid= 7719706 |doi= }}
*{{cite journal | author=Martin MM, Elton TS |title=The sequence and genomic organization of the human type 2 angiotensin II receptor. |journal=Biochem. Biophys. Res. Commun. |volume=209 |issue= 2 |pages= 554-62 |year= 1995 |pmid= 7733925 |doi= 10.1006/bbrc.1995.1537 }}
*{{cite journal | author=Chassagne C, Beatty BG, Meloche S |title=Assignment of the human angiotensin II type 2 receptor gene (AGTR2) to chromosome Xq22-q23 by fluorescence in situ hybridization. |journal=Genomics |volume=25 |issue= 2 |pages= 601-3 |year= 1995 |pmid= 7790004 |doi= }}
*{{cite journal | author=Koike G, Horiuchi M, Yamada T, ''et al.'' |title=Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung. |journal=Biochem. Biophys. Res. Commun. |volume=203 |issue= 3 |pages= 1842-50 |year= 1994 |pmid= 7945336 |doi= 10.1006/bbrc.1994.2402 }}
*{{cite journal | author=Martin MM, Su B, Elton TS |title=Molecular cloning of the human angiotensin II type 2 receptor cDNA. |journal=Biochem. Biophys. Res. Commun. |volume=205 |issue= 1 |pages= 645-51 |year= 1995 |pmid= 7999093 |doi= }}
*{{cite journal | author=Tsuzuki S, Ichiki T, Nakakubo H, ''et al.'' |title=Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor. |journal=Biochem. Biophys. Res. Commun. |volume=200 |issue= 3 |pages= 1449-54 |year= 1994 |pmid= 8185599 |doi= 10.1006/bbrc.1994.1613 }}
*{{cite journal | author=Servant G, Boulay G, Bossé R, ''et al.'' |title=Photoaffinity labeling of subtype 2 angiotensin receptor of human myometrium. |journal=Mol. Pharmacol. |volume=43 |issue= 5 |pages= 677-83 |year= 1993 |pmid= 8502225 |doi= }}
*{{cite journal | author=Yamada T, Horiuchi M, Dzau VJ |title=Angiotensin II type 2 receptor mediates programmed cell death. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 1 |pages= 156-60 |year= 1996 |pmid= 8552595 |doi= }}
*{{cite journal | author=Zhang J, Pratt RE |title=The AT2 receptor selectively associates with Gialpha2 and Gialpha3 in the rat fetus. |journal=J. Biol. Chem. |volume=271 |issue= 25 |pages= 15026-33 |year= 1996 |pmid= 8663053 |doi= }}
*{{cite journal | author=Katsuya T, Horiuchi M, Minami S, ''et al.'' |title=Genomic organization and polymorphism of human angiotensin II type 2 receptor: no evidence for its gene mutation in two families of human premature ovarian failure syndrome. |journal=Mol. Cell. Endocrinol. |volume=127 |issue= 2 |pages= 221-8 |year= 1997 |pmid= 9099917 |doi= }}
*{{cite journal | author=Akishita M, Ito M, Lehtonen JY, ''et al.'' |title=Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth. |journal=J. Clin. Invest. |volume=103 |issue= 1 |pages= 63-71 |year= 1999 |pmid= 9884335 |doi= }}
*{{cite journal | author=Lehtonen JY, Daviet L, Nahmias C, ''et al.'' |title=Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis. |journal=Mol. Endocrinol. |volume=13 |issue= 7 |pages= 1051-60 |year= 1999 |pmid= 10406457 |doi= }}
*{{cite journal | author=Knowle D, Ahmed S, Pulakat L |title=Identification of an interaction between the angiotensin II receptor sub-type AT2 and the ErbB3 receptor, a member of the epidermal growth factor receptor family. |journal=Regul. Pept. |volume=87 |issue= 1-3 |pages= 73-82 |year= 2000 |pmid= 10710290 |doi= }}
*{{cite journal | author=Hansen JL, Servant G, Baranski TJ, ''et al.'' |title=Functional reconstitution of the angiotensin II type 2 receptor and G(i) activation. |journal=Circ. Res. |volume=87 |issue= 9 |pages= 753-9 |year= 2000 |pmid= 11055978 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on AGTRL1... {November 24, 2007 2:38:56 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 24, 2007 2:39:49 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Angiotensin II receptor-like 1
| HGNCid = 339
| Symbol = AGTRL1
| AltSymbols =; APJ; FLJ90771; MGC45246
| OMIM = 600052
| ECnumber =
| Homologene = 3784
| MGIid = 1346086
| GeneAtlas_image1 = PBB_GE_AGTRL1_213592_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 187
| Hs_Ensembl = ENSG00000134817
| Hs_RefseqProtein = NP_005152
| Hs_RefseqmRNA = NM_005161
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 56757630
| Hs_GenLoc_end = 56761364
| Hs_Uniprot = P35414
| Mm_EntrezGene = 23796
| Mm_Ensembl = ENSMUSG00000044338
| Mm_RefseqmRNA = NM_011784
| Mm_RefseqProtein = NP_035914
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 84937225
| Mm_GenLoc_end = 84940762
| Mm_Uniprot = Q8BKS8
}}
}}
'''Angiotensin II receptor-like 1''', also known as '''AGTRL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AGTRL1 angiotensin II receptor-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=187| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = There are at least two distinct receptor subtypes of angiotensin II: angiotensin II receptor, type 1 (AGTR1) and angiotensin II receptor, type 2 (AGTR2). Most of the effects of angiotensin II are mediated by the AGTR1 receptor. This gene is related to the AGTR1 gene by sequence similarity. It was cloned based on a conserved transmembrane domain found in members of the G protein-coupled receptor (GPCR) gene family.<ref name="entrez">{{cite web | title = Entrez Gene: AGTRL1 angiotensin II receptor-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=187| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Choe H, Martin KA, Farzan M, ''et al.'' |title=Structural interactions between chemokine receptors, gp120 Env and CD4. |journal=Semin. Immunol. |volume=10 |issue= 3 |pages= 249-57 |year= 1998 |pmid= 9653051 |doi= }}
*{{cite journal | author=O'Dowd BF, Heiber M, Chan A, ''et al.'' |title=A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. |journal=Gene |volume=136 |issue= 1-2 |pages= 355-60 |year= 1994 |pmid= 8294032 |doi= }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal | author=Matsumoto M, Hidaka K, Akiho H, ''et al.'' |title=Low stringency hybridization study of the dopamine D4 receptor revealed D4-like mRNA distribution of the orphan seven-transmembrane receptor, APJ, in human brain. |journal=Neurosci. Lett. |volume=219 |issue= 2 |pages= 119-22 |year= 1997 |pmid= 8971794 |doi= }}
*{{cite journal | author=Hoffman TL, Stephens EB, Narayan O, Doms RW |title=HIV type I envelope determinants for use of the CCR2b, CCR3, STRL33, and APJ coreceptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 19 |pages= 11360-5 |year= 1998 |pmid= 9736741 |doi= }}
*{{cite journal | author=Tatemoto K, Hosoya M, Habata Y, ''et al.'' |title=Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. |journal=Biochem. Biophys. Res. Commun. |volume=251 |issue= 2 |pages= 471-6 |year= 1998 |pmid= 9792798 |doi= 10.1006/bbrc.1998.9489 }}
*{{cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, ''et al.'' |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491-6 |year= 2000 |pmid= 10737800 |doi= }}
*{{cite journal | author=O'Carroll AM, Selby TL, Palkovits M, Lolait SJ |title=Distribution of mRNA encoding B78/apj, the rat homologue of the human APJ receptor, and its endogenous ligand apelin in brain and peripheral tissues. |journal=Biochim. Biophys. Acta |volume=1492 |issue= 1 |pages= 72-80 |year= 2000 |pmid= 11004481 |doi= }}
*{{cite journal | author=Puffer BA, Sharron M, Coughlan CM, ''et al.'' |title=Expression and coreceptor function of APJ for primate immunodeficiency viruses. |journal=Virology |volume=276 |issue= 2 |pages= 435-44 |year= 2000 |pmid= 11040134 |doi= 10.1006/viro.2000.0557 }}
*{{cite journal | author=Katugampola SD, Maguire JJ, Matthewson SR, Davenport AP |title=[(125)I]-(Pyr(1))Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man. |journal=Br. J. Pharmacol. |volume=132 |issue= 6 |pages= 1255-60 |year= 2001 |pmid= 11250876 |doi= 10.1038/sj.bjp.0703939 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Medhurst AD, Jennings CA, Robbins MJ, ''et al.'' |title=Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. |journal=J. Neurochem. |volume=84 |issue= 5 |pages= 1162-72 |year= 2003 |pmid= 12603839 |doi= }}
*{{cite journal | author=Zhou N, Fan X, Mukhtar M, ''et al.'' |title=Cell-cell fusion and internalization of the CNS-based, HIV-1 co-receptor, APJ. |journal=Virology |volume=307 |issue= 1 |pages= 22-36 |year= 2003 |pmid= 12667811 |doi= }}
*{{cite journal | author=Lee DK, Lança AJ, Cheng R, ''et al.'' |title=Agonist-independent nuclear localization of the Apelin, angiotensin AT1, and bradykinin B2 receptors. |journal=J. Biol. Chem. |volume=279 |issue= 9 |pages= 7901-8 |year= 2004 |pmid= 14645236 |doi= 10.1074/jbc.M306377200 }}
*{{cite journal | author=Zhou N, Zhang X, Fan X, ''et al.'' |title=The N-terminal domain of APJ, a CNS-based coreceptor for HIV-1, is essential for its receptor function and coreceptor activity. |journal=Virology |volume=317 |issue= 1 |pages= 84-94 |year= 2004 |pmid= 14675627 |doi= }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ishida J, Hashimoto T, Hashimoto Y, ''et al.'' |title=Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo. |journal=J. Biol. Chem. |volume=279 |issue= 25 |pages= 26274-9 |year= 2004 |pmid= 15087458 |doi= 10.1074/jbc.M404149200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Kleinz MJ, Skepper JN, Davenport AP |title=Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells. |journal=Regul. Pept. |volume=126 |issue= 3 |pages= 233-40 |year= 2005 |pmid= 15664671 |doi= 10.1016/j.regpep.2004.10.019 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on AVPR1A... {November 24, 2007 2:39:49 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 24, 2007 2:41:16 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Arginine vasopressin receptor 1A
| HGNCid = 895
| Symbol = AVPR1A
| AltSymbols =; AVPR1
| OMIM = 600821
| ECnumber =
| Homologene = 568
| MGIid = 1859216
| GeneAtlas_image1 = PBB_GE_AVPR1A_206251_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_AVPR1A_206250_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_AVPR1A_206252_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005000 |text = vasopressin receptor activity}} {{GNF_GO|id=GO:0005080 |text = protein kinase C binding}}
| Component = {{GNF_GO|id=GO:0005768 |text = endosome}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006091 |text = generation of precursor metabolites and energy}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007202 |text = phospholipase C activation}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}} {{GNF_GO|id=GO:0008015 |text = circulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 552
| Hs_Ensembl = ENSG00000166148
| Hs_RefseqProtein = NP_000697
| Hs_RefseqmRNA = NM_000706
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 61826483
| Hs_GenLoc_end = 61832857
| Hs_Uniprot = P37288
| Mm_EntrezGene = 54140
| Mm_Ensembl = ENSMUSG00000020123
| Mm_RefseqmRNA = NM_016847
| Mm_RefseqProtein = NP_058543
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 121851559
| Mm_GenLoc_end = 121856513
| Mm_Uniprot = Q3U1H9
}}
}}
'''Arginine vasopressin receptor 1A''', also known as '''AVPR1A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AVPR1A arginine vasopressin receptor 1A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=552| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis.<ref name="entrez">{{cite web | title = Entrez Gene: AVPR1A arginine vasopressin receptor 1A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=552| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Thibonnier M, Coles P, Thibonnier A, Shoham M |title=Molecular pharmacology and modeling of vasopressin receptors. |journal=Prog. Brain Res. |volume=139 |issue= |pages= 179-96 |year= 2002 |pmid= 12436935 |doi= }}
*{{cite journal | author=Cross SH, Charlton JA, Nan X, Bird AP |title=Purification of CpG islands using a methylated DNA binding column. |journal=Nat. Genet. |volume=6 |issue= 3 |pages= 236-44 |year= 1994 |pmid= 8012384 |doi= 10.1038/ng0394-236 }}
*{{cite journal | author=Hirasawa A, Shibata K, Kotosai K, Tsujimoto G |title=Cloning, functional expression and tissue distribution of human cDNA for the vascular-type vasopressin receptor. |journal=Biochem. Biophys. Res. Commun. |volume=203 |issue= 1 |pages= 72-9 |year= 1994 |pmid= 8074728 |doi= 10.1006/bbrc.1994.2150 }}
*{{cite journal | author=Thibonnier M, Auzan C, Madhun Z, ''et al.'' |title=Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor. |journal=J. Biol. Chem. |volume=269 |issue= 5 |pages= 3304-10 |year= 1994 |pmid= 8106369 |doi= }}
*{{cite journal | author=Young WS, Kovács K, Lolait SJ |title=The diurnal rhythm in vasopressin V1a receptor expression in the suprachiasmatic nucleus is not dependent on vasopressin. |journal=Endocrinology |volume=133 |issue= 2 |pages= 585-90 |year= 1993 |pmid= 8344200 |doi= }}
*{{cite journal | author=Thibonnier M, Graves MK, Wagner MS, ''et al.'' |title=Structure, sequence, expression, and chromosomal localization of the human V1a vasopressin receptor gene. |journal=Genomics |volume=31 |issue= 3 |pages= 327-34 |year= 1997 |pmid= 8838314 |doi= 10.1006/geno.1996.0055 }}
*{{cite journal | author=North WG, Fay MJ, Longo K, Du J |title=Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma. |journal=Peptides |volume=18 |issue= 7 |pages= 985-93 |year= 1998 |pmid= 9357056 |doi= }}
*{{cite journal | author=North WG, Fay MJ, Longo KA, Du J |title=Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide. |journal=Cancer Res. |volume=58 |issue= 9 |pages= 1866-71 |year= 1998 |pmid= 9581826 |doi= }}
*{{cite journal | author=North WG, Fay MJ, Du J |title=MCF-7 breast cancer cells express normal forms of all vasopressin receptors plus an abnormal V2R. |journal=Peptides |volume=20 |issue= 7 |pages= 837-42 |year= 1999 |pmid= 10477084 |doi= }}
*{{cite journal | author=Tahara A, Tsukada J, Ishii N, ''et al.'' |title=Comparison of vasopressin binding sites in human uterine and vascular smooth muscle cells. |journal=Eur. J. Pharmacol. |volume=378 |issue= 1 |pages= 137-42 |year= 1999 |pmid= 10478574 |doi= }}
*{{cite journal | author=Thibonnier M, Graves MK, Wagner MS, ''et al.'' |title=Study of V(1)-vascular vasopressin receptor gene microsatellite polymorphisms in human essential hypertension. |journal=J. Mol. Cell. Cardiol. |volume=32 |issue= 4 |pages= 557-64 |year= 2000 |pmid= 10756113 |doi= 10.1006/jmcc.2000.1108 }}
*{{cite journal | author=Berrada K, Plesnicher CL, Luo X, Thibonnier M |title=Dynamic interaction of human vasopressin/oxytocin receptor subtypes with G protein-coupled receptor kinases and protein kinase C after agonist stimulation. |journal=J. Biol. Chem. |volume=275 |issue= 35 |pages= 27229-37 |year= 2000 |pmid= 10858434 |doi= 10.1074/jbc.M002288200 }}
*{{cite journal | author=Kim SJ, Young LJ, Gonen D, ''et al.'' |title=Transmission disequilibrium testing of arginine vasopressin receptor 1A (AVPR1A) polymorphisms in autism. |journal=Mol. Psychiatry |volume=7 |issue= 5 |pages= 503-7 |year= 2002 |pmid= 12082568 |doi= 10.1038/sj.mp.4001125 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Tahtaoui C, Balestre MN, Klotz P, ''et al.'' |title=Identification of the binding sites of the SR49059 nonpeptide antagonist into the V1a vasopressin receptor using sulfydryl-reactive ligands and cysteine mutants as chemical sensors. |journal=J. Biol. Chem. |volume=278 |issue= 41 |pages= 40010-9 |year= 2003 |pmid= 12869559 |doi= 10.1074/jbc.M301128200 }}
*{{cite journal | author=Hawtin SR, Wesley VJ, Simms J, ''et al.'' |title=An arginyl in the N-terminus of the V1a vasopressin receptor is part of the conformational switch controlling activation by agonist. |journal=Eur. J. Biochem. |volume=270 |issue= 23 |pages= 4681-8 |year= 2004 |pmid= 14622255 |doi= }}
*{{cite journal | author=Terrillon S, Barberis C, Bouvier M |title=Heterodimerization of V1a and V2 vasopressin receptors determines the interaction with beta-arrestin and their trafficking patterns. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 6 |pages= 1548-53 |year= 2004 |pmid= 14757828 |doi= 10.1073/pnas.0305322101 }}
*{{cite journal | author=Wassink TH, Piven J, Vieland VJ, ''et al.'' |title=Examination of AVPR1a as an autism susceptibility gene. |journal=Mol. Psychiatry |volume=9 |issue= 10 |pages= 968-72 |year= 2005 |pmid= 15098001 |doi= 10.1038/sj.mp.4001503 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on AVPR1B... {November 24, 2007 2:41:16 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 24, 2007 2:42:16 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Arginine vasopressin receptor 1B
| HGNCid = 896
| Symbol = AVPR1B
| AltSymbols =; AVPR3
| OMIM = 600264
| ECnumber =
| Homologene = 22678
| MGIid = 1347010
| GeneAtlas_image1 = PBB_GE_AVPR1B_208260_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005000 |text = vasopressin receptor activity}} {{GNF_GO|id=GO:0005080 |text = protein kinase C binding}}
| Component = {{GNF_GO|id=GO:0005768 |text = endosome}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007202 |text = phospholipase C activation}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 553
| Hs_Ensembl = ENSG00000198049
| Hs_RefseqProtein = NP_000698
| Hs_RefseqmRNA = NM_000707
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 204390599
| Hs_GenLoc_end = 204398262
| Hs_Uniprot = P47901
| Mm_EntrezGene = 26361
| Mm_Ensembl = ENSMUSG00000026432
| Mm_RefseqmRNA = NM_011924
| Mm_RefseqProtein = NP_036054
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 133427287
| Mm_GenLoc_end = 133439546
| Mm_Uniprot = Q9JLP2
}}
}}
'''Arginine vasopressin receptor 1B''', also known as '''AVPR1B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AVPR1B arginine vasopressin receptor 1B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=553| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known.<ref name="entrez">{{cite web | title = Entrez Gene: AVPR1B arginine vasopressin receptor 1B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=553| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Thibonnier M, Coles P, Thibonnier A, Shoham M |title=Molecular pharmacology and modeling of vasopressin receptors. |journal=Prog. Brain Res. |volume=139 |issue= |pages= 179-96 |year= 2002 |pmid= 12436935 |doi= }}
*{{cite journal | author=de Keyzer Y, Auzan C, Lenne F, ''et al.'' |title=Cloning and characterization of the human V3 pituitary vasopressin receptor. |journal=FEBS Lett. |volume=356 |issue= 2-3 |pages= 215-20 |year= 1995 |pmid= 7805841 |doi= }}
*{{cite journal | author=Sugimoto T, Saito M, Mochizuki S, ''et al.'' |title=Molecular cloning and functional expression of a cDNA encoding the human V1b vasopressin receptor. |journal=J. Biol. Chem. |volume=269 |issue= 43 |pages= 27088-92 |year= 1994 |pmid= 7929452 |doi= }}
*{{cite journal | author=Rousseau-Merck MF, René P, Derré J, ''et al.'' |title=Chromosomal localization of the human V3 pituitary vasopressin receptor gene (AVPR3) to 1q32. |journal=Genomics |volume=30 |issue= 2 |pages= 405-6 |year= 1996 |pmid= 8586456 |doi= }}
*{{cite journal | author=de Keyzer Y, Lenne F, Auzan C, ''et al.'' |title=The pituitary V3 vasopressin receptor and the corticotroph phenotype in ectopic ACTH syndrome. |journal=J. Clin. Invest. |volume=97 |issue= 5 |pages= 1311-8 |year= 1996 |pmid= 8636444 |doi= }}
*{{cite journal | author=North WG, Fay MJ, Longo K, Du J |title=Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma. |journal=Peptides |volume=18 |issue= 7 |pages= 985-93 |year= 1998 |pmid= 9357056 |doi= }}
*{{cite journal | author=North WG, Fay MJ, Longo KA, Du J |title=Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide. |journal=Cancer Res. |volume=58 |issue= 9 |pages= 1866-71 |year= 1998 |pmid= 9581826 |doi= }}
*{{cite journal | author=North WG, Fay MJ, Du J |title=MCF-7 breast cancer cells express normal forms of all vasopressin receptors plus an abnormal V2R. |journal=Peptides |volume=20 |issue= 7 |pages= 837-42 |year= 1999 |pmid= 10477084 |doi= }}
*{{cite journal | author=René P, Lenne F, Ventura MA, ''et al.'' |title=Nucleotide sequence and structural organization of the human vasopressin pituitary receptor (V3) gene. |journal=Gene |volume=241 |issue= 1 |pages= 57-64 |year= 2000 |pmid= 10607899 |doi= }}
*{{cite journal | author=Berrada K, Plesnicher CL, Luo X, Thibonnier M |title=Dynamic interaction of human vasopressin/oxytocin receptor subtypes with G protein-coupled receptor kinases and protein kinase C after agonist stimulation. |journal=J. Biol. Chem. |volume=275 |issue= 35 |pages= 27229-37 |year= 2000 |pmid= 10858434 |doi= 10.1074/jbc.M002288200 }}
*{{cite journal | author=Zemo DA, McCabe JT |title=Salt-loading increases vasopressin and vasopressin 1b receptor mRNA in the hypothalamus and choroid plexus. |journal=Neuropeptides |volume=35 |issue= 3-4 |pages= 181-8 |year= 2002 |pmid= 11884209 |doi= 10.1054/npep.2001.0864 }}
*{{cite journal | author=Folny V, Raufaste D, Lukovic L, ''et al.'' |title=Pancreatic vasopressin V1b receptors: characterization in In-R1-G9 cells and localization in human pancreas. |journal=Am. J. Physiol. Endocrinol. Metab. |volume=285 |issue= 3 |pages= E566-76 |year= 2003 |pmid= 12736162 |doi= 10.1152/ajpendo.00148.2003 }}
*{{cite journal | author=van West D, Del-Favero J, Aulchenko Y, ''et al.'' |title=A major SNP haplotype of the arginine vasopressin 1B receptor protects against recurrent major depression. |journal=Mol. Psychiatry |volume=9 |issue= 3 |pages= 287-92 |year= 2004 |pmid= 15094789 |doi= 10.1038/sj.mp.4001420 }}
*{{cite journal | author=Robert J, Clauser E, Petit PX, Ventura MA |title=A novel C-terminal motif is necessary for the export of the vasopressin V1b/V3 receptor to the plasma membrane. |journal=J. Biol. Chem. |volume=280 |issue= 3 |pages= 2300-8 |year= 2005 |pmid= 15528211 |doi= 10.1074/jbc.M410655200 }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal | author=Young SF, Griffante C, Aguilera G |title=Dimerization between vasopressin V1b and corticotropin releasing hormone type 1 receptors. |journal=Cell. Mol. Neurobiol. |volume=27 |issue= 4 |pages= 439-61 |year= 2007 |pmid= 17318384 |doi= 10.1007/s10571-006-9135-8 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on AVPR2... {November 24, 2007 2:42:16 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 24, 2007 2:43:12 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Arginine vasopressin receptor 2 (nephrogenic diabetes insipidus)
| HGNCid = 897
| Symbol = AVPR2
| AltSymbols =; ADHR; DI1; DIR; DIR3; MGC126533; MGC138386; NDI; V2R
| OMIM = 300538
| ECnumber =
| Homologene = 20064
| MGIid = 88123
| GeneAtlas_image1 = PBB_GE_AVPR2_208111_at_tn.png
| GeneAtlas_image2 = PBB_GE_AVPR2_208108_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005000 |text = vasopressin receptor activity}}
| Component = {{GNF_GO|id=GO:0005768 |text = endosome}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007188 |text = G-protein signaling, coupled to cAMP nucleotide second messenger}} {{GNF_GO|id=GO:0007190 |text = adenylate cyclase activation}} {{GNF_GO|id=GO:0007588 |text = excretion}} {{GNF_GO|id=GO:0007599 |text = hemostasis}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 554
| Hs_Ensembl = ENSG00000126895
| Hs_RefseqProtein = NP_000045
| Hs_RefseqmRNA = NM_000054
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 152823383
| Hs_GenLoc_end = 152825834
| Hs_Uniprot = P30518
| Mm_EntrezGene = 12000
| Mm_Ensembl = ENSMUSG00000031390
| Mm_RefseqmRNA = NM_019404
| Mm_RefseqProtein = NP_062277
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 70126278
| Mm_GenLoc_end = 70147147
| Mm_Uniprot = Q3KNZ4
}}
}}
'''Arginine vasopressin receptor 2 (nephrogenic diabetes insipidus)''', also known as '''AVPR2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AVPR2 arginine vasopressin receptor 2 (nephrogenic diabetes insipidus)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=554| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The human AVPR2 locus encodes the vasopressin receptor, type 2, also known as the V2 receptor, located in cytogenetic band Xq28. The gene's three exons and two introns are contained within 2.1 kilobases. The L1CAM gene lies some 29 kb centromeric to AVPR2, and the C1 gene immediately teleomeric. Both are apparently transcribed in opposite orientation to AVPR2 (see NID g1302657). The AVPR2 protein product belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and it couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. AVPR2 expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing.<ref name="entrez">{{cite web | title = Entrez Gene: AVPR2 arginine vasopressin receptor 2 (nephrogenic diabetes insipidus)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=554| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Birnbaumer M |title=The V2 vasopressin receptor mutations and fluid homeostasis. |journal=Cardiovasc. Res. |volume=51 |issue= 3 |pages= 409-15 |year= 2001 |pmid= 11476731 |doi= }}
*{{cite journal | author=Ishikawa SE |title=[Nephrogenic diabetes insipidus associated with mutations of vasopressin V2 receptors and aquaporin-2] |journal=Nippon Rinsho |volume=60 |issue= 2 |pages= 350-5 |year= 2002 |pmid= 11857925 |doi= }}
*{{cite journal | author=Thibonnier M, Coles P, Thibonnier A, Shoham M |title=Molecular pharmacology and modeling of vasopressin receptors. |journal=Prog. Brain Res. |volume=139 |issue= |pages= 179-96 |year= 2002 |pmid= 12436935 |doi= }}
*{{cite journal | author=Bichet DG |title=Nephrogenic diabetes insipidus. |journal=Advances in chronic kidney disease |volume=13 |issue= 2 |pages= 96-104 |year= 2006 |pmid= 16580609 |doi= 10.1053/j.ackd.2006.01.006 }}
*{{cite journal | author=Robben JH, Knoers NV, Deen PM |title=Cell biological aspects of the vasopressin type-2 receptor and aquaporin 2 water channel in nephrogenic diabetes insipidus. |journal=Am. J. Physiol. Renal Physiol. |volume=291 |issue= 2 |pages= F257-70 |year= 2006 |pmid= 16825342 |doi= 10.1152/ajprenal.00491.2005 }}
*{{cite journal | author=Pan Y, Metzenberg A, Das S, ''et al.'' |title=Mutations in the V2 vasopressin receptor gene are associated with X-linked nephrogenic diabetes insipidus. |journal=Nat. Genet. |volume=2 |issue= 2 |pages= 103-6 |year= 1993 |pmid= 1303257 |doi= 10.1038/ng1092-103 }}
*{{cite journal | author=van den Ouweland AM, Dreesen JC, Verdijk M, ''et al.'' |title=Mutations in the vasopressin type 2 receptor gene (AVPR2) associated with nephrogenic diabetes insipidus. |journal=Nat. Genet. |volume=2 |issue= 2 |pages= 99-102 |year= 1993 |pmid= 1303271 |doi= 10.1038/ng1092-99 }}
*{{cite journal | author=van den Ouweland AM, Knoop MT, Knoers VV, ''et al.'' |title=Colocalization of the gene for nephrogenic diabetes insipidus (DIR) and the vasopressin type 2 receptor gene (AVPR2) in the Xq28 region. |journal=Genomics |volume=13 |issue= 4 |pages= 1350-2 |year= 1992 |pmid= 1324225 |doi= }}
*{{cite journal | author=Rosenthal W, Seibold A, Antaramian A, ''et al.'' |title=Molecular identification of the gene responsible for congenital nephrogenic diabetes insipidus. |journal=Nature |volume=359 |issue= 6392 |pages= 233-5 |year= 1992 |pmid= 1356229 |doi= 10.1038/359233a0 }}
*{{cite journal | author=Seibold A, Brabet P, Rosenthal W, Birnbaumer M |title=Structure and chromosomal localization of the human antidiuretic hormone receptor gene. |journal=Am. J. Hum. Genet. |volume=51 |issue= 5 |pages= 1078-83 |year= 1992 |pmid= 1415251 |doi= }}
*{{cite journal | author=Birnbaumer M, Seibold A, Gilbert S, ''et al.'' |title=Molecular cloning of the receptor for human antidiuretic hormone. |journal=Nature |volume=357 |issue= 6376 |pages= 333-5 |year= 1992 |pmid= 1534149 |doi= 10.1038/357333a0 }}
*{{cite journal | author=Lolait SJ, O'Carroll AM, McBride OW, ''et al.'' |title=Cloning and characterization of a vasopressin V2 receptor and possible link to nephrogenic diabetes insipidus. |journal=Nature |volume=357 |issue= 6376 |pages= 336-9 |year= 1992 |pmid= 1534150 |doi= 10.1038/357336a0 }}
*{{cite journal | author=Knoers N, van der Heyden H, van Oost BA, ''et al.'' |title=Three-point linkage analysis using multiple DNA polymorphic markers in families with X-linked nephrogenic diabetes insipidus. |journal=Genomics |volume=4 |issue= 3 |pages= 434-7 |year= 1989 |pmid= 2714800 |doi= }}
*{{cite journal | author=Tsukaguchi H, Matsubara H, Taketani S, ''et al.'' |title=Binding-, intracellular transport-, and biosynthesis-defective mutants of vasopressin type 2 receptor in patients with X-linked nephrogenic diabetes insipidus. |journal=J. Clin. Invest. |volume=96 |issue= 4 |pages= 2043-50 |year= 1995 |pmid= 7560098 |doi= }}
*{{cite journal | author=Faà V, Ventruto ML, Loche S, ''et al.'' |title=Mutations in the vasopressin V2-receptor gene in three families of Italian descent with nephrogenic diabetes insipidus. |journal=Hum. Mol. Genet. |volume=3 |issue= 9 |pages= 1685-6 |year= 1995 |pmid= 7833930 |doi= }}
*{{cite journal | author=Birnbaumer M, Gilbert S, Rosenthal W |title=An extracellular congenital nephrogenic diabetes insipidus mutation of the vasopressin receptor reduces cell surface expression, affinity for ligand, and coupling to the Gs/adenylyl cyclase system. |journal=Mol. Endocrinol. |volume=8 |issue= 7 |pages= 886-94 |year= 1995 |pmid= 7984150 |doi= }}
*{{cite journal | author=Wenkert D, Merendino JJ, Shenker A, ''et al.'' |title=Novel mutations in the V2 vasopressin receptor gene of patients with X-linked nephrogenic diabetes insipidus. |journal=Hum. Mol. Genet. |volume=3 |issue= 8 |pages= 1429-30 |year= 1995 |pmid= 7987330 |doi= }}
*{{cite journal | author=Oksche A, Dickson J, Schülein R, ''et al.'' |title=Two novel mutations in the vasopressin V2 receptor gene in patients with congenital nephrogenic diabetes insipidus. |journal=Biochem. Biophys. Res. Commun. |volume=205 |issue= 1 |pages= 552-7 |year= 1995 |pmid= 7999078 |doi= 10.1006/bbrc.1994.2700 }}
*{{cite journal | author=Bichet DG, Birnbaumer M, Lonergan M, ''et al.'' |title=Nature and recurrence of AVPR2 mutations in X-linked nephrogenic diabetes insipidus. |journal=Am. J. Hum. Genet. |volume=55 |issue= 2 |pages= 278-86 |year= 1994 |pmid= 8037205 |doi= }}
*{{cite journal | author=Yuasa H, Ito M, Oiso Y, ''et al.'' |title=Novel mutations in the V2 vasopressin receptor gene in two pedigrees with congenital nephrogenic diabetes insipidus. |journal=J. Clin. Endocrinol. Metab. |volume=79 |issue= 2 |pages= 361-5 |year= 1994 |pmid= 8045948 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on BAI1... {November 24, 2007 2:43:12 PM PST}
- CREATE: Found no pages, creating new page. {November 24, 2007 2:44:05 PM PST}
- CREATED: Created new protein page: BAI1 {November 24, 2007 2:44:21 PM PST}
- INFO: Beginning work on BAI2... {November 24, 2007 2:44:21 PM PST}
- CREATE: Found no pages, creating new page. {November 24, 2007 2:45:17 PM PST}
- CREATED: Created new protein page: BAI2 {November 24, 2007 2:45:29 PM PST}
- INFO: Beginning work on BAI3... {November 24, 2007 2:45:30 PM PST}
- CREATE: Found no pages, creating new page. {November 24, 2007 2:45:56 PM PST}
- CREATED: Created new protein page: BAI3 {November 24, 2007 2:46:08 PM PST}
- INFO: Beginning work on OPN1SW... {November 24, 2007 2:46:08 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 24, 2007 2:46:55 PM PST}
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{{PBB_Controls
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| update_protein_box = yes
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}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)
| HGNCid = 1012
| Symbol = OPN1SW
| AltSymbols =; BCP; BOP; CBT
| OMIM = 190900
| ECnumber =
| Homologene = 1291
| MGIid = 99438
| GeneAtlas_image1 = PBB_GE_OPN1SW_208036_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0009882 |text = blue light photoreceptor activity}}
| Component = {{GNF_GO|id=GO:0001750 |text = photoreceptor outer segment}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0007602 |text = phototransduction}} {{GNF_GO|id=GO:0018298 |text = protein-chromophore linkage}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 611
| Hs_Ensembl = ENSG00000128617
| Hs_RefseqProtein = NP_001699
| Hs_RefseqmRNA = NM_001708
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 128199783
| Hs_GenLoc_end = 128203087
| Hs_Uniprot = P03999
| Mm_EntrezGene = 12057
| Mm_Ensembl = ENSMUSG00000058831
| Mm_RefseqmRNA = NM_007538
| Mm_RefseqProtein = NP_031564
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 29326667
| Mm_GenLoc_end = 29330490
| Mm_Uniprot = P51491
}}
}}
'''Opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)''', also known as '''OPN1SW''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OPN1SW opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=611| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Applebury ML, Hargrave PA |title=Molecular biology of the visual pigments. |journal=Vision Res. |volume=26 |issue= 12 |pages= 1881-95 |year= 1987 |pmid= 3303660 |doi= }}
*{{cite journal | author=Swanson WH, Cohen JM |title=Color vision. |journal=Ophthalmology clinics of North America |volume=16 |issue= 2 |pages= 179-203 |year= 2003 |pmid= 12809157 |doi= }}
*{{cite journal | author=Weitz CJ, Went LN, Nathans J |title=Human tritanopia associated with a third amino acid substitution in the blue-sensitive visual pigment. |journal=Am. J. Hum. Genet. |volume=51 |issue= 2 |pages= 444-6 |year= 1992 |pmid= 1386496 |doi= }}
*{{cite journal | author=Weitz CJ, Miyake Y, Shinzato K, ''et al.'' |title=Human tritanopia associated with two amino acid substitutions in the blue-sensitive opsin. |journal=Am. J. Hum. Genet. |volume=50 |issue= 3 |pages= 498-507 |year= 1992 |pmid= 1531728 |doi= }}
*{{cite journal | author=Oprian DD, Asenjo AB, Lee N, Pelletier SL |title=Design, chemical synthesis, and expression of genes for the three human color vision pigments. |journal=Biochemistry |volume=30 |issue= 48 |pages= 11367-72 |year= 1992 |pmid= 1742276 |doi= }}
*{{cite journal | author=Sarkar G, Sommer SS |title=Access to a messenger RNA sequence or its protein product is not limited by tissue or species specificity. |journal=Science |volume=244 |issue= 4902 |pages= 331-4 |year= 1989 |pmid= 2565599 |doi= }}
*{{cite journal | author=Nathans J, Thomas D, Hogness DS |title=Molecular genetics of human color vision: the genes encoding blue, green, and red pigments. |journal=Science |volume=232 |issue= 4747 |pages= 193-202 |year= 1986 |pmid= 2937147 |doi= }}
*{{cite journal | author=Nathans J, Piantanida TP, Eddy RL, ''et al.'' |title=Molecular genetics of inherited variation in human color vision. |journal=Science |volume=232 |issue= 4747 |pages= 203-10 |year= 1986 |pmid= 3485310 |doi= }}
*{{cite journal | author=Fitzgibbon J, Appukuttan B, Gayther S, ''et al.'' |title=Localisation of the human blue cone pigment gene to chromosome band 7q31.3-32. |journal=Hum. Genet. |volume=93 |issue= 1 |pages= 79-80 |year= 1994 |pmid= 8270261 |doi= }}
*{{cite journal | author=Shimmin LC, Mai P, Li WH |title=Sequences and evolution of human and squirrel monkey blue opsin genes. |journal=J. Mol. Evol. |volume=44 |issue= 4 |pages= 378-82 |year= 1997 |pmid= 9089077 |doi= }}
*{{cite journal | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal | author=Gunther KL, Neitz J, Neitz M |title=A novel mutation in the short-wavelength-sensitive cone pigment gene associated with a tritan color vision defect. |journal=Vis. Neurosci. |volume=23 |issue= 3-4 |pages= 403-9 |year= 2006 |pmid= 16961973 |doi= 10.1017/S0952523806233169 }}
}}
{{refend}}
{{protein-stub}}
end log.
