Clinical data | |
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Trade names | DynaCirc, Prescal |
AHFS/Drugs.com | Monograph |
MedlinePlus | a693048 |
Pregnancy category |
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Routes of administration | By mouth |
Drug class | Calcium channel blocker (dihydropyridine) |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 15-24% |
Protein binding | 95% |
Metabolism | 100% liver |
Elimination half-life | 8 hours |
Excretion | 70% kidney, 30% fecal |
Identifiers | |
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Chemical and physical data | |
Formula | C19H21N3O5 |
Molar mass | 371.393 g·mol−1 |
3D model (JSmol) | |
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Isradipine, sold under the brand name DynaCirc among others, is a medication used to treat high blood pressure.[1] For this use it is one of a number of first line agents.[1] It is taken by mouth.[1] Maximal effect may take up to four weeks.[1]
Common side effects include headache, swelling, palpitations, and lightheadedness.[1] Other side effects may include worsening heart failure, chest pain, and low blood pressure.[1] Safety in pregnancy is unclear.[2] It is a calcium channel blocker of the dihydropyridine class.[1]
Isradipine was patented in 1978 and approved for medical use in 1989.[3] IT is available as a generic medication.[4] In the United States, at a dose of 5 mg twice per day, it costs about 27 USD per month.[4]
References
edit- ^ a b c d e f g h i "Isradipine Monograph for Professionals". Drugs.com. Archived from the original on 31 August 2021. Retrieved 1 December 2021.
- ^ "Isradipine Use During Pregnancy". Drugs.com. Archived from the original on 24 October 2020. Retrieved 1 December 2021.
- ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 465. ISBN 9783527607495. Archived from the original on 2021-08-27. Retrieved 2021-10-09.
- ^ a b "Isradipine Prices, Coupons & Savings Tips". GoodRx. Archived from the original on 20 September 2016. Retrieved 1 December 2021.