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Dihydropyridine (DHP) is a molecule based upon pyridine, and the parent of a class of molecules that have been semi-saturated with two substituents replacing one double bond. They are particularly well known in pharmacology as L-type calcium channel blockers, used in the treatment of hypertension. Compared with certain other L-type calcium channel blockers (for example those of the phenylalkylamine class such as verapamil) that have significant action at the heart, they are relatively vascular selective in their mechanism of action in lowering blood pressure.

Dihydropyridine
Skeletal formula of dihydropyridine
Ball-and-stick model of the dihydropyridine molecule
Names
Systematic IUPAC name
1,4-Dihydropyridine[1]
Identifiers
3D model (JSmol)
ChemSpider
MeSH 1,4-dihydropyridine
Properties
C
5
H
7
N
Molar mass 81.1158 g mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Class membersEdit

Dihydropyridine class L-type calcium channel blockers include, in alphabetical order (brand names vary in different countries):

Name Image Brand name
Amlodipine Norvasc, Istin, Normodipine, Tenox, Cordi Cor
Aranidipine Sapresta (サプレスタ)
Azelnidipine CalBlock (カルブロック)
Barnidipine Vasexten, Libradin, Cyress, HypoCa
Benidipine Coniel
Cilnidipine Atelec (アテレック), Cilacar, Cinalong, Siscard
Clevidipine Cleviprex
Cronidipine
Darodipine
Dexniguldipine
Efonidipine Landel (ランデル)
Elgodipine
Elnadipine
Felodipine Renedil, Plendil
Flordipine
Furnidipine
Iganidipine
Isradipine DynaCirc CR
Lacidipine Lacipil, Motens, Sakure
Lemildipine
Lercanidipine Zanidip, Zanidip-Recordati
Levamlodipine EsCordi Cor
Levniguldipine
Manidipine Manyper, Caslot, Madipine
Nicardipine Cardene, Cardene SR
Nifedipine Adalat, Nifedical, Procardia, Corinfar, Cordaflex
Niguldipine
Niludipine
Nilvadipine Nivadil
Nimodipine Nimotop
Nisoldipine Sular, Baymycard, Syscor
Nitrendipine Baypress, Cardif, Nitrepin, Baylotensin
Olradipine
Oxodipine
Palonidipine
Pranidipine Acalas
Ryodipine
Sagandipine
Sornidipine
Teludipine
Tiamdipine
Trombodipine
Vatanidipine

The pharmaceutical drug finerenone is also a dihydrophyridine derivative, but does not act as a calcium channel blocker but as an antimineralocorticoid.

See alsoEdit

ReferencesEdit

  1. ^ "1,4-dihydropyridine - Compound Summary". Pubchem Compound. USA: National Center for Biotechnology Information. 27 March 2005. Identification and Related Records. Retrieved 1 November 2011.

External linksEdit