 | |
 | |
| Clinical data | |
|---|---|
| Trade names | Corlopam |
| Other names | Fenoldopam mesylate |
| AHFS/Drugs.com | Monograph |
| Routes of administration | IV |
| Drug class | Dopamine D1 receptor agonist[1] |
| Legal status | |
| Legal status |
|
| Pharmacokinetic data | |
| Metabolism | Liver (CYP not involved) |
| Onset of action | Within 10 min[2] |
| Elimination half-life | 5 minutes |
| Duration of action | An hour[2] |
| Excretion | Kidney (90%) and fecal (10%) |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C16H16ClNO3 |
| Molar mass | 305.76 g·mol−1 |
| 3D model (JSmol) | |
| Chirality | Racemic mixture |
| |
| |
  (what is this?) (verify) | |
Fenoldopam, sold under the brand name Corlopam, is a medication used to treat high blood pressure.[3] Specifically it is used short term for hypertensive emergencies.[3] It is given by continuous injection into a vein.[3] Effects begin within 10 minutes and last for up to an hour.[2]
Common side effects include headache, flushing, nausea, and low blood pressure.[3] Other side effects may include anaphylaxis, palpitations, low potassium, and increased eye pressure.[3] Risk in pregnancy is unclear.[4] It is a dopamine D1 receptor agonist which results in blood vessel dilation.[3][1] It is a benzazepine derivative.[3]
Fenoldopam was approved for medical use in the United States in 1997.[3] It is available as a generic medication.[2] In the United States it costs about 400 USD per 10 mg as of 2021.[5]
References edit
- ^ a b "Drug Information Portal - U.S. National Library of Medicine - Quick Access to Quality Drug Information". druginfo.nlm.nih.gov. Archived from the original on 28 April 2021. Retrieved 10 December 2021.
- ^ a b c d e Szymanski, Michael W.; Richards, John R. (2021), "Fenoldopam", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 30252314, archived from the original on 2020-08-12, retrieved 2021-05-02
- ^ a b c d e f g h i j "Fenoldopam Monograph for Professionals". Drugs.com. Archived from the original on 12 May 2021. Retrieved 10 December 2021.
- ^ "Fenoldopam (Corlopam) Use During Pregnancy". Drugs.com. Archived from the original on 4 December 2020. Retrieved 10 December 2021.
- ^ "Corlopam Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 10 December 2021.