Clinical data | |
---|---|
Trade names | Cleviprex |
AHFS/Drugs.com | Monograph |
License data |
|
Routes of administration | Intravenous |
Drug class | Calcium channel blocker (dihydropyridine)[1] |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 100% (used only IV) |
Protein binding | >99.5% |
Metabolism | Blood and tissue esterases |
Onset of action | With 4 min[1] |
Elimination half-life | 1 minute |
Duration of action | Up to 15 min[1] |
Excretion | Urine (63–74%), feces (7–22%) |
Identifiers | |
| |
Chemical and physical data | |
Formula | C21H23Cl2NO6 |
Molar mass | 456.32 g·mol−1 |
3D model (JSmol) | |
Chirality | Racemic mixture |
|
Clevidipine, sold under the brand name Cleviprex, is a medication used to treat high blood pressure.[1] This includes in hypertensive emergencies and around the time of surgery.[1] It is used by injection into a vein.[1] Effects begin within 4 minutes and last for up to 15 minutes.[1]
Common side effects include headache and nausea.[3] Other side effects may include low blood pressure, fast heart rate, and worsened heart failure.[3] It should not be used in those allergic to eggs or soy.[3] There are concerns that use during pregnancy may harm the baby.[4] It is a calcium channel blocker of the dihydropyridine type.[1]
Clevidipine was approved for medical use in the United States in 2008.[1] It is also available in a number of European countries.[5] In the United States 50 mg costs about 160 USD as of 2022.[6]
References
edit- ^ a b c d e f g h i j "Clevidipine Monograph for Professionals". Drugs.com. Archived from the original on 10 June 2021. Retrieved 5 January 2022.
- ^ "Archive copy" (PDF). Archived (PDF) from the original on 2021-11-02. Retrieved 2021-10-31.
{{cite web}}
: CS1 maint: archived copy as title (link) - ^ a b c d "DailyMed - CLEVIPREX- clevidipine emulsion". dailymed.nlm.nih.gov. Archived from the original on 2 March 2021. Retrieved 5 January 2022.
- ^ "Clevidipine (Cleviprex) Use During Pregnancy". Drugs.com. Archived from the original on 26 November 2020. Retrieved 5 January 2022.
- ^ "List of nationally authorised medicinal products" (PDF). Archived (PDF) from the original on 5 July 2019. Retrieved 5 January 2022.
- ^ "Cleviprex Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 18 January 2021. Retrieved 5 January 2022.