User:Mr. Ibrahem/Chlorambucil

Mr. Ibrahem/Chlorambucil
Clinical data
Trade names	Leukeran, others
AHFS/Drugs.com	Monograph
MedlinePlus	a682899
Routes of; administration	By mouth
Drug class	Alkylating agent
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	?
Metabolism	Liver
Elimination half-life	1.5 hours
Excretion	N/A
Identifiers
	IUPAC name 4-[bis(2-chlorethyl)amino]benzenebutanoic acid;
Chemical and physical data
Formula	C14H19Cl2NO2
Molar mass	304.21 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c1cc(ccc1CCCC(=O)O)N(CCCl)CCCl;
	InChI InChI=1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19) ; Key:JCKYGMPEJWAADB-UHFFFAOYSA-N ;
	(verify)

Chlorambucil, sold under the brand name Leukeran among others, is a chemotherapy medication used to treat chronic lymphocytic leukemia (CLL), Hodgkin lymphoma, and non-Hodgkin lymphoma.^[2] For CLL it is a preferred treatment.^[1] It is given by mouth.^[1]

Common side effects include bone marrow suppression.^[1] Other serious side effects include an increased long term risk of further cancer, infertility, and allergic reactions.^[1] Use during pregnancy often results in harm to the baby.^[1] Chlorambucil is in the alkylating agent family of medications.^[1] It works by blocking the formation of DNA and RNA.^[1]

Chlorambucil was approved for medical use in the United States in 1957.^[1] It is on the World Health Organization's List of Essential Medicines.^[4] The wholesale cost in the developing world is about US$111.87 per month.^[5] In the United Kingdom it costs the NHS about £145.84 per month.^[6] It was originally made from nitrogen mustard.^[1]

References

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Chlorambucil". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
^ ^a ^b "Chlorambucil". National Cancer Institute. 17 September 2014. Archived from the original on 21 December 2016. Retrieved 19 December 2016.
^ Cite error: The named reference who was invoked but never defined (see the help page).
^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^ "Chlorambucil". International Drug Price Indicator Guide. Archived from the original on 29 March 2019. Retrieved 8 December 2016.
^ British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 580. ISBN 9780857111562.