Clinical data | |
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Pronunciation | /brɛkˈspɪprəzoʊl/ brek-SPIP-rə-zohl /rɛkˈsʌlti/ rek-SUL-tee |
Trade names | Rexulti, Rxulti |
Other names | OPC-34712 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a615046 |
License data |
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Pregnancy category |
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Routes of administration | By mouth (tablets) |
Drug class | Atypical antipsychotic[2] |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 95% (Tmax = 4 hours)[4] |
Protein binding | >99% |
Metabolism | Liver (mainly mediated by CYP3A4 and CYP2D6) |
Elimination half-life | 91 hours (brexpiprazole), 86 hours (major metabolite) |
Excretion | Feces (46%), urine (25%) |
Identifiers | |
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Chemical and physical data | |
Formula | C25H27N3O2S |
Molar mass | 433.57 g·mol−1 |
3D model (JSmol) | |
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Brexpiprazole, sold under the brand name Rexulti among others, is an atypical antipsychotic used to treat schizophrenia, and major depressive disorder (MDD).[2] In schizophrenia it may be used in those over the age of 12.[2] It is taken by mouth.[5]
Common side effects include weight gain and a movement disorder known as akathisia.[2] Other side effects may include neuroleptic malignant syndrome, tardive dyskinesia, diabetes, problem gambling, and low white blood cells.[2] Use in older people with dementia increases the risk of death.[2] Safety in pregnancy is unclear.[6] It is believed to work by affecting dopamine, serotonin, and noradrenaline in the brain.[5]
Brexpiprazole was approved for medical use in the United States in 2015 and Europe in 2018.[2][5] It is not available in the United Kingdom as of 2022.[7] In the United States it costs about 1,200 USD per month as of 2022, regardless of the dose.[8]
References edit
- ^ a b "Brexpiprazole (Rexulti) Use During Pregnancy". Drugs.com. 10 February 2020. Archived from the original on 5 December 2020. Retrieved 18 August 2020.
- ^ a b c d e f g h i "DailyMed - REXULTI- brexpiprazole tablet". dailymed.nlm.nih.gov. Archived from the original on 11 May 2021. Retrieved 11 January 2022.
- ^ "Summary for ARTG Entry:273224 Rexulti brexpiprazole 4 mg film coated tablets blisters". Therapeutic Goods Administration (TGA). Retrieved 18 August 2020.
{{cite web}}
: CS1 maint: url-status (link) - ^ "REXULTI® (brexpiprazole) Tablets, for Oral Use. Full Prescribing Information" (PDF). Rexulti (brexpiprazole) Patient Site. Otsuka Pharmaceutical Co., Ltd., Tokyo, 101-8535 Japan. Archived (PDF) from the original on 5 March 2016. Retrieved 15 July 2015.
- ^ a b c "Rxulti". Archived from the original on 12 January 2022. Retrieved 11 January 2022.
- ^ "Brexpiprazole (Rexulti) Use During Pregnancy". Drugs.com. Archived from the original on 5 December 2020. Retrieved 11 January 2022.
- ^ "Brexpiprazole". SPS - Specialist Pharmacy Service. 10 February 2016. Archived from the original on 12 January 2022. Retrieved 11 January 2022.
- ^ "Brexpiprazole Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 11 January 2022.