Drlutz

Possible Topics:
ROCK kinase+ signaling pathway: maybe expand regulation or homologues section, make sure there is enough additional information
Myosin light-chain kinase: plenty of room for expansion
Breast Cancer Tumor Suppressant Gene: not enough room for expansion and too medically relevant
Motor Protein: Not enough room for expansion, given its more specific
Molecular Motor: Can expand on general functions nicely

Peer review on Myosin light-chain kinase article

Cynthia's peer-review:

• Content:

Overall I find the information necessary and relevant. Since I've learned the basic smooth muscle cross-bridge cycle regulation too, I'd say I can't think of anything else to add to this article. You could introduce the striated muscle contraction regulation pathway (through calcium binding to troponin C), but I don't think it is super necessary, because this article is about MYLK which regulates the muscle contraction of smooth muscles.

• Citation

You did a great job in citation of your part of the article (it seems enough to me). However, the other part of the article did not so well, so you might want to look into it too if necessary.

1. No citation of the "Function" Section
2. The "Mutations and resulting diseases" section has much information but with only one citation, maybe you could read into that and see if there're extra articles to back it up?

• Clarity

1. In the upstream regulation part, it says "Rho kinase also modulates the activity of MYLK by downregulating the activity of MYLK's counterpart protein: Myosin Light Chain Phosphatase (MYLP).^[7] In addition to downregulation of MYLK...". If Rho kinase mentioned by the editor is ROCK Kinase, shouldn't it be "in addition to downregulation of MLC phosphatase" rather than "MYLK" according to the context?
2. About the statement “Similar to ROCK, Protein Kinase C regulates MYLK via the CPI-17 protein, which downregulates MYLP”, do you mean that they downregulates MYLP via the same pathway or just they have a similar function, which is downregulating MYLP (in which case, you might want to switch the downregulating part first. For example, "Similar to ROCK, PKc downregulates MYLP but via a different pathway"). This kind of feedback might seem too detailed, but at lease to me as a reader I would have this kind of confusions when reading the article.
3. Maybe you want to hyperlink the proteins you mentioned in this paragraph, in case people want to know more about them.
4. Sentences in the “Mutations and resulting diseases” section are long and some contain too much information that the editor fails to present clearly.

• Supplemental graph

1. Maybe you can create a simple graph for the MYLK function part, to illustrate how MLC kinase is activated and how it plays into the phosphorylation of MLC to initiates cross-bridge cycle. Visual information would be more direct for high school students who might find it hard to follow the verbal description, where there are many terminologies.