The biosynthesis of atropine starting from L-Phenylalanine first undergoes a transamination forming phenylpyruvic acid which is then reduced to phenyl-lactic acid [1]. Coenzyme A then couples phenyl-lactic acid with tropine forming littorine, which then undergoes a radical rearrangement initiated with a P450 enzyme forming hyoscyamine aldehyde[2]. A dehydrogenase then reduces the aldehyde to a primary alcohol making (-)-hyoscamine, which upon racemization forms atropine[3].
- ^ Dewick, Paul M. (2009). Medicinal natural products : A biosynthetic approach (3rd ed.). Chichester: A John Wiley & Sons. ISBN 978-0470741672
- ^ Dewick, Paul M. (2009). Medicinal natural products : A biosynthetic approach (3rd ed.). Chichester: A John Wiley & Sons. ISBN 978-0470741672
- ^ Dewick, Paul M. (2009). Medicinal natural products : A biosynthetic approach (3rd ed.). Chichester: A John Wiley & Sons. ISBN 978-0470741672