start work on Lysergic acid diethylamide table:
| Site | Ki (nM) | Species | Ref |
|---|---|---|---|
| SERT | >30,000 | Human | [3][4] |
| NET | >30,000 | Human | [3] |
| DAT | >10,000 | Human | [4][3] |
| 5-HT1A | >10,000 | Human | |
| 5-HT1B | >10,000 | Human | |
| 5-HT1D | >10,000 | Human | |
| 5-HT1E | >10,000 | Human | |
| 5-HT2A | >10,000 | Human | |
| 5-HT2B | >10,000 | Human | |
| 5-HT2C | >10,000 | Human | |
| 5-HT3 | >10,000 | Human | |
| 5-HT5A | >10,000 | Human | |
| 5-HT6 | >10,000 | Human | |
| 5-HT7 | 0.39 - 199.5 (8.7) | Rat Guinea Pig |
|
| α1A | 670.0 | Human | [3] |
| α2A | 12.0 | Human | [3] |
| β1 | 140.0 | Human | [5] |
| β2 | 740.0 | Human | [5] |
| D1 | 273.0 - 310.0 30.0 180.0 |
Human Calf Rat |
[4][3] [2] [5] |
| D2 | 25.0 - 38.8 120.0 |
Human Rat |
[4][3] [5] |
| D3 | 27.1 - 96.0 27.0 |
Human Rat |
[4][3] [5] |
| D4 | 330.0 56.0 |
Human Rat |
[4] [5] |
| D5 | 340.0 | Rat | [5] |
| H1 | 1,100 1,300 - 1,540 |
Human Rat (brain) |
[3] [6] [5] |
| TARR | >10,000 450 |
Mouse Rat |
[3] [3] |
| Values are Ki (nM), unless otherwise noted. The smaller the value, the more strongly the drug interacts with the site. | |||
- ^ Roth, BL; Driscol, J. "PDSP Ki Database". Psychoactive Drug Screening Program (PDSP). University of North Carolina at Chapel Hill and the United States National Institute of Mental Health.
{{cite web}}:|access-date=requires|url=(help); Missing or empty|url=(help) - ^ a b Burt, DR; Creese, I; Snyder, SH (September 1976). "Properties of [3H]haloperidol and [3H]dopamine binding associated with dopamine receptors in calf brain membranes". Molecular pharmacology. 12 (5): 800–12. PMID 995128.
- ^ a b c d e f g h i j k l Rickli, Anna; Luethi, Dino; Reinisch, Julian; Buchy, Danièle; Hoener, Marius C.; Liechti, Matthias E. (December 2015). "Receptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2,5-dimethoxy-substituted phenethylamines (2C drugs)". Neuropharmacology. 99: 546–553. doi:10.1016/j.neuropharm.2015.08.034.
- ^ a b c d e f g Janowsky, Aaron; Eshleman, Amy J.; Johnson, Robert A.; Wolfrum, Katherine M.; Hinrichs, David J.; Yang, Jongtae; Zabriskie, T. Mark; Smilkstein, Martin J.; Riscoe, Michael K. (July 2014). "Mefloquine and psychotomimetics share neurotransmitter receptor and transporter interactions in vitro". Psychopharmacology. 231 (14): 2771–2783. doi:10.1007/s00213-014-3446-0.
- ^ a b c d e f g h Nichols, David E.; Frescas, Stewart; Marona-Lewicka, Danuta; Kurrasch-Orbaugh, Deborah M. (1 September 2002). "Lysergamides of Isomeric 2,4-Dimethylazetidines Map the Binding Orientation of the Diethylamide Moiety in the Potent Hallucinogenic Agent N , N -Diethyllysergamide (LSD)". Journal of Medicinal Chemistry. 45 (19): 4344–4349. doi:10.1021/jm020153s.
- ^ Tran, V T; Chang, R S; Snyder, S H (December 1978). "Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramine". Proceedings of the National Academy of Sciences. 75 (12): 6290–6294. doi:10.1073/pnas.75.12.6290.