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An Error has occurred retrieving Wikidata item for infobox Tetratricopeptide repeat 39A is a human protein encoded by the TTC39A gene. Other known aliases are TTC39A, differentially expressed in MCF7 with estradiol protein 6 (DEME-6), KIAA0452, and c1orf34[1] . TTC39A is induced by TFAP2C in hormone responsive breast carcinoma cells[2] and TTC39A is expressed in estrogen receptor positive carcinoma cell lines[3].

The TTC39A gene is located on the first chromosome at 1p32.3[4].

The location of TTC39A at 1p.32.3

The genomic DNA is 57,859 bases long, consists of 19 exons and is located on the minus strand[5]. The mRNA has a length of 2759 bases[6].

The longest protein sequence consists of 613 amino acids[7]. Within TTC39A, there is a domain of unknown function, DUF 3808[8]. DUF 3808 is generally considered to be an outer mitochondrial membrane protein and has been conserved from fungi to humans[9]. DUF 3808 also contains a tetratricopeptide, TPR_16 and a predicted transmembrane domain[10][11] .

File:TTC39Aproteinfeatures.png
Protein features including the location of DUF3808, TPR_16, and the circled predicted transmembrane domain

Homology

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TTC39A has several orthologs that have been found in eukaryotes, archea, and bacteria[12]. Two paralogs, TTC39B and TTC39C, have also been identified[13].

Species Common Name Accession Number Length Protein Identity Protein Similarity
Homo Sapiens Human NP_001073963.1 613aa 100% 100%
Mus musculus Mouse NP_001139420.1 578aa/2334bp 87.9% 91.0%
Macaca mulatta Rhesus Monkey XP_002801613.1 550aa/2747bp 92.0% 93.0%
Gallus gallus Chicken XP_422466.3 575aa/3614bp 71.3% 81.0%
Taeniopygia guttata Zebra Finch XP_002193183 575aa/1729bp 73.0% 82.0%
Anolis carolinensis Green Anole XP_003216860.1 570aa/1713bp 58.8% 74.0%
Danio rerio Zebra Fish XP_002663143.1 598aa/1980bp 60.8% 76.0%
Branchiostoma floridae Florida Lancelet XP_002591442.1 544aa/1632bp 41.1% 61.0%
Physcomitrella patens Moss XP_001766901.1 601aa/2225bp 24.2% 41.0%
Leishmania braziliensis Euglenazoa XP_001566995.1 584aa/1775bp 21.8% 40.0%
Aster yellows phytoplasma Phytoplasma AAO61940.1 299aa/1423bp 15.1% 42.0%

Expression

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There are 17 splice varients for TTC39A[14]. TTC39A is highly expressed protein in the human body[15] . The highest levels of expression are located in mammary glands and testis[16]. The lowest levels of expression are found in the immune system[17].

 
The expression levels of TTC39A found throughout the human body

Protein Properties

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TTC39A is predicted to have 12 alpha helices and a single beta sheet[18].

Post Translational Modifications

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There are several predicted phosphorylation sites but none have been experimentally confirmed[19]. A single sulfination site is predicted at position 175[20].

Interactions

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TTC39A has been found to interact with butyrophilin-like 2[21] and Mapk3[22].

Further Reading

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References

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  1. ^ [www.ncbi.nlm.nih.gov "National Center for Biotechnology Information"]. Retrieved 15 April 2012. {{cite web}}: Check |url= value (help)
  2. ^ Woodfield, George W.; Chen, Yizhen; Bair, Thomas B.; Domann, Frederick E.; Weigel, Ronald J. (2010). "Identification of Primary Gene Targets of TFAP2C in Homrone Responsive Breast Carcinoma Cells". Genes Chromosomes Cancer. 49 (10): 948–962. doi:10.1002/gcc.20807. PMC 2928401. PMID 20629094. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: date and year (link)
  3. ^ Kuang, W.; Thompson, D. A.; Hoch, R. V.; Weigel, R. J. (15). "Differential screening and suppression subtractive hybridization identified genes differentially expressed in an estrogen receptor-positive breast carcinoma cell line". Nucleic Acids Research. 26 (4): 1116–1123. doi:10.1093/nar/26.4.1116. PMC 147366. PMID 9461476. {{cite journal}}: Check date values in: |date= and |year= / |date= mismatch (help); Unknown parameter |month= ignored (help)
  4. ^ [www.genecards.org "Genecards"]. Retrieved 15 April 2012. {{cite web}}: Check |url= value (help)
  5. ^ [www.genecards.org "Genecards"]. Retrieved 15 April 2012. {{cite web}}: Check |url= value (help)
  6. ^ [www.genecards.org "Genecards"]. Retrieved 15 April 2012. {{cite web}}: Check |url= value (help)
  7. ^ [www.ncbi.nlm.gov "National Center for Biotechnology Information"]. Retrieved 17 April 2012. {{cite web}}: Check |url= value (help)
  8. ^ [www.ncbi.nlm.gov "National Center for Biotechnology Information"]. Retrieved 17 April 2012. {{cite web}}: Check |url= value (help)
  9. ^ [www.ncbi.nlm.gov "National Center for Biotechnology Information"]. Retrieved 17 April 2012. {{cite web}}: Check |url= value (help)
  10. ^ [www.ncbi.nlm.gov "National Center for Biotechnology Information"]. Retrieved 17 April 2012. {{cite web}}: Check |url= value (help)
  11. ^ "San Diego Biology Workbench". Predicted transmembrane domains.
  12. ^ [www.genecards.org "Genecards"]. Retrieved 15 April 2012. {{cite web}}: Check |url= value (help)
  13. ^ [www.genecards.org "Genecards"]. Retrieved 15 April 2012. {{cite web}}: Check |url= value (help)
  14. ^ "Aceview".
  15. ^ "Aceview".
  16. ^ [www.ncbi.nlm.nih.gov "National Center for Biotechnology Information"]. Retrieved 15 April 2012. {{cite web}}: Check |url= value (help)
  17. ^ [www.ncbi.nlm.nih.gov "National Center for Biotechnology Information"]. Retrieved 15 April 2012. {{cite web}}: Check |url= value (help)
  18. ^ "San Diego Supercomputer Biology Workbench Pele".
  19. ^ "Netphos".
  20. ^ "Expasy Sulfinator".
  21. ^ "String:Functional Protein Association Networks".
  22. ^ "Mint: Molecular Interaction Database".
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