Adoptive cell transfer (ACT) is the transfer of cells into a patient. The cells may have originated from the patient him- or herself and then been altered before being transferred back, or, they may have come from another individual. The cells are most commonly derived from the immune system, with the goal of transferring improved immune functionality and characteristics along with the cells back to the patient. Transferring autologous cells, or cells from the patient, minimizes graft-versus-host disease (GVHD) or what is more casually described as tissue or organ rejection.
Cancer therapy
editApproaches
editTILs approach
editGenetic engineering approach
edit... explain what a TCR does normally= killing mechanism...="cell death mechansim"
TCRs
edit-short description how it is build up (alpha+beta subunit...) ( nevertheless link to "TCR")
-which antigens are tackled until now
-challenges + solutions ( example: alpha and beta subunit shuffling)
-implementation in practice (ex: putting alpha and beta on same rna strand)