The incumbent was Republican Alan Nunnelee, who had represented the district since 2011. He was re-elected with 60% of the vote in 2012 and the district has a PVI of R+16.
Nunnelee was the only Congressman in Mississippi who did not face a primary opponent in 2014. Democrats Ron Dickey and Rex Weathers, who was a candidate for the seat in 1992 and 1996 and the nominee for the seat in 1998 and 2002, ran. Nunnelee died on February 6, 2015, shortly after starting his third term in office.
Danny Bedwell, Chairman of the Mississippi Libertarian Party, was the Libertarian nominee.
The incumbent was Republican Gregg Harper, who had represented the district since 2009. He was re-elected with 80% of the vote in 2012 and the district had a PVI of R+14.
Hardy Caraway, an Independent candidate for the 2nd district in 1984 and the Republican nominee for the 2nd district in 2000 was running against Harper in the Republican primary. Democrats Jim Liljeberg; Doug Magee, who was a Republican candidate for the 4th district in 1988; and Dennis Quinn also ran.
Chris McDaniel, a Republican member of the Mississippi State Senate, considered challenging Palazzo in the primary, but chose instead to run for the United States Senate. Taylor, who served in the U.S. House from 1989 to 2011, has switched parties, and ran for the seat as a Republican.
Tavish Kelly, Tom Carter, and Ron Vincent, who was a candidate for the seat in 2012, also ran against Palazzo.
Democrats Trish Causey and Matthew Moore, who was the nominee for the seat in 2012, also ran.