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UV radiation resistance-associated gene protein is a protein that in humans is encoded by the UVRAG gene.[5][6]

UVRAG
Identifiers
AliasesUVRAG, DHTX, VPS38, p63, UV radiation resistance associated
External IDsOMIM: 602493 MGI: 1925860 HomoloGene: 31150 GeneCards: UVRAG
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for UVRAG
Genomic location for UVRAG
Band11q13.5Start75,815,210 bp[1]
End76,144,232 bp[1]
RNA expression pattern
PBB GE UVRAG 203241 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003369

NM_178635

RefSeq (protein)

NP_003360

NP_848750

Location (UCSC)Chr 11: 75.82 – 76.14 MbChr 7: 98.89 – 99.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.[6]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198382 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035354 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Perelman B, Dafni N, Naiman T, Eli D, Yaakov M, Feng TL, Sinha S, Weber G, Khodaei S, Sancar A, Dotan I, Canaani D (Jul 1997). "Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus". Genomics. 41 (3): 397–405. doi:10.1006/geno.1997.4623. PMID 9169138.
  6. ^ a b "Entrez Gene: UVRAG UV radiation resistance associated gene".

Further readingEdit