UQCR10

Ubiquinol-cytochrome c reductase complex (7.2 kD), also known as UCRC or UQCR10, is a human gene.

UQCR10
Identifiers
Aliases	UQCR10, HSPC051, HSPC151, QCR9, UCCR7.2, UCRC, HSPC119, ubiquinol-cytochrome c reductase, complex III subunit X
External IDs	OMIM: 610843; MGI: 1913402; HomoloGene: 40876; GeneCards: UQCR10; OMA:UQCR10 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q12.2 Start 29,767,369 bp End 29,770,413 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 A1 Start 4,651,973 bp End 4,654,342 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of tongue lateral nuclear group of thalamus Skeletal muscle tissue of rectus abdominis external globus pallidus right ventricle thoracic diaphragm pars reticulata pars compacta pons biceps brachii Top expressed in right kidney choroid plexus of fourth ventricle muscle of thigh blastocyst interventricular septum plantaris muscle yolk sac lip extensor digitorum longus muscle superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquinol-cytochrome-c reductase activity Cellular component mitochondrial inner membrane respirasome membrane mitochondrion mitochondrial respiratory chain complex III Biological process mitochondrial respiratory chain complex III assembly mitochondrial electron transport, ubiquinol to cytochrome c aerobic respiration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29796 66152 Ensembl ENSG00000184076 ENSMUSG00000059534 UniProt Q9UDW1 Q8R1I1 RefSeq (mRNA) NM_013387 NM_001003684 NM_001047158 NM_197979 NM_001362879 RefSeq (protein) NP_001003684 NP_037519 NP_932096 NP_001349808 Location (UCSC) Chr 22: 29.77 – 29.77 Mb Chr 11: 4.65 – 4.65 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes: UQCRC1, UQCRC2, Cytochrome c1, UQCRFS1 (Rieske protein), UQCRB, UQCRQ [1]("11kDa protein"), UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, UCRC("cyt. c1 associated protein"), and UQCR [2]("Rieske-associated protein").

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Schägger H, Brandt U, Gencic S, von Jagow G (1995). "Ubiquinol-cytochrome-c reductase from human and bovine mitochondria". Mitochondrial Biogenesis and Genetics Part A. Methods in Enzymology. Vol. 260. pp. 82–96. doi:10.1016/0076-6879(95)60132-5. ISBN 978-0-12-182161-6. PMID 8592474.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Iwata S, Lee JW, Okada K, et al. (1998). "Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex". Science. 281 (5373): 64–71. Bibcode:1998Sci...281...64I. doi:10.1126/science.281.5373.64. PMID 9651245.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 171–84. PMID 12107413.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Guzy RD, Hoyos B, Robin E, et al. (2005). "Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing". Cell Metab. 1 (6): 401–8. doi:10.1016/j.cmet.2005.05.001. PMID 16054089.