UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase

UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase (EC 2.3.1.201, WbpD, WlbB) is an enzyme with systematic name acetyl-CoA:UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate N-acetyltransferase.[1][2] This enzyme catalyses the following chemical reaction

UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase
Identifiers
EC no.2.3.1.201
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins
acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate CoA + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate

This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid).

References

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  1. ^ Westman EL, McNally DJ, Charchoglyan A, Brewer D, Field RA, Lam JS (May 2009). "Characterization of WbpB, WbpE, and WbpD and reconstitution of a pathway for the biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-D-mannuronic acid in Pseudomonas aeruginosa". The Journal of Biological Chemistry. 284 (18): 11854–62. doi:10.1074/jbc.M808583200. PMC 2673254. PMID 19282284.
  2. ^ Larkin A, Imperiali B (June 2009). "Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: enzymes in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1". Biochemistry. 48 (23): 5446–55. doi:10.1021/bi900186u. PMC 2694220. PMID 19348502.
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