UBL5

Ubiquitin-like protein 5 is a protein that in humans is encoded by the UBL5 gene.

UBL5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1P0R, 4PYU
Identifiers
Aliases	UBL5, HUB1, ubiquitin like 5
External IDs	OMIM: 606849; MGI: 1913427; HomoloGene: 83305; GeneCards: UBL5; OMA:UBL5 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.2 Start 9,827,892 bp End 9,830,115 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A3 Start 20,642,878 bp End 20,647,140 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary right testis left testis right adrenal gland mucosa of transverse colon left adrenal cortex right adrenal cortex C1 segment anterior cingulate cortex monocyte Top expressed in choroid plexus of fourth ventricle interventricular septum corneal stroma ventricular zone cardiac muscle tissue of left ventricle yolk sac lip granulocyte zygote plantaris muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein tag Cellular component cytoplasm nucleus Biological process mRNA splicing, via spliceosome positive regulation of protein targeting to mitochondrion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 59286 66177 Ensembl ENSG00000198258 ENSMUSG00000084786 UniProt Q9BZL1 Q9EPV8 RefSeq (mRNA) NM_024292 NM_001048241 NM_025401 NM_001310746 RefSeq (protein) NP_001041706 NP_077268 NP_001041706.1 NP_077268.1 NP_001297675 NP_079677 NP_001347954 NP_001347955 NP_001347956 Location (UCSC) Chr 19: 9.83 – 9.83 Mb Chr 9: 20.64 – 20.65 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

It has been shown that in C. elegans mitochondria treated to lower expression of certain electron transport chain proteins during the L3/L4 stage, its expression levels is higher leading to increased lifespans.

Ubiquitin-like proteins (UBLs) are thought to be reversible modulators of protein function rather than protein degraders like ubiquitin (MIM 191339).[supplied by OMIM]

Further reading

• Friedman JS, Koop BF, Raymond V, Walter MA (2001). "Isolation of a ubiquitin-like (UBL5) gene from a screen identifying highly expressed and conserved iris genes". Genomics. 71 (2): 252–5. doi:10.1006/geno.2000.6439. PMID 11161819.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kantham L, Kerr-Bayles L, Godde N, et al. (2003). "Beacon interacts with cdc2/cdc28-like kinases". Biochem. Biophys. Res. Commun. 304 (1): 125–9. doi:10.1016/S0006-291X(03)00549-7. PMID 12705895.
• McNally T, Huang Q, Janis RS, et al. (2004). "Structural analysis of UBL5, a novel ubiquitin-like modifier". Protein Sci. 12 (7): 1562–6. doi:10.1110/ps.0382803. PMC 2323916. PMID 12824502.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wilkinson CR, Dittmar GA, Ohi MD, et al. (2005). "Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast". Curr. Biol. 14 (24): 2283–8. doi:10.1016/j.cub.2004.11.058. PMID 15620657.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9BZL1 (Human Ubiquitin-like protein 5) at the PDBe-KB.
• Overview of all the structural information available in the PDB for UniProt: Q9EPV8 (Mouse Ubiquitin-like protein 5) at the PDBe-KB.