Ubiquitin conjugation factor E4 B is a protein that in humans is encoded by the UBE4B gene.[5][6][7]

UBE4B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesUBE4B, E4, HDNB1, UBOX3, UFD2, UFD2A, ubiquitination factor E4B
External IDsOMIM: 613565; MGI: 1927086; HomoloGene: 107623; GeneCards: UBE4B; OMA:UBE4B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001105562
NM_006048

NM_022022

RefSeq (protein)

NP_001099032
NP_006039

NP_071305
NP_001391797
NP_001391798

Location (UCSC)Chr 1: 10.03 – 10.18 MbChr 4: 149.33 – 149.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s.

This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes.[7]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130939Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028960Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  6. ^ Koegl M, Hoppe T, Schlenker S, Ulrich HD, Mayer TU, Jentsch S (Apr 1999). "A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly". Cell. 96 (5): 635–44. doi:10.1016/S0092-8674(00)80574-7. PMID 10089879.
  7. ^ a b "Entrez Gene: UBE4B ubiquitination factor E4B (UFD2 homolog, yeast)".

Further reading

edit
edit