Ubiquitin/ISG15-conjugating enzyme E2 L6 is a protein that in humans is encoded by the UBE2L6 gene.[5][6]

UBE2L6
Protein UBE2L6 PDB 1wzv.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesUBE2L6, RIG-B, UBCH8, ubiquitin conjugating enzyme E2 L6
External IDsOMIM: 603890 MGI: 1914500 HomoloGene: 3112 GeneCards: UBE2L6
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198183
NM_004223

NM_019949

RefSeq (protein)

NP_004214
NP_937826

NP_064333

Location (UCSC)Chr 11: 57.55 – 57.57 MbChr 2: 84.63 – 84.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1S), ubiquitin-conjugating enzymes (E2S) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family.

This enzyme is highly similar in primary structure to the enzyme encoded by UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[6]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000156587 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027078 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kumar S, Kao WH, Howley PM (Jul 1997). "Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity". J Biol Chem. 272 (21): 13548–54. doi:10.1074/jbc.272.21.13548. PMID 9153201.
  6. ^ a b "Entrez Gene: UBE2L6 ubiquitin-conjugating enzyme E2L 6".

Further readingEdit