Tropomodulin 4 (muscle) also known as TMOD4 is a protein which in humans is encoded by the TMOD4 gene.[5][6]

TMOD4
Identifiers
AliasesTMOD4, SK-TMOD, tropomodulin 4
External IDsOMIM: 605834; MGI: 1355285; HomoloGene: 8355; GeneCards: TMOD4; OMA:TMOD4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013353

NM_016712

RefSeq (protein)

NP_037485

NP_057921

Location (UCSC)Chr 1: 151.17 – 151.18 MbChr 3: 95.03 – 95.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene encodes a muscle-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163157Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005628Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cox PR, Zoghbi HY (January 2000). "Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs". Genomics. 63 (1): 97–107. doi:10.1006/geno.1999.6061. PMID 10662549.
  6. ^ Almenar-Queralt A, Lee A, Conley CA, Ribas de Pouplana L, Fowler VM (October 1999). "Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle". J. Biol. Chem. 274 (40): 28466–75. doi:10.1074/jbc.274.40.28466. PMID 10497209.
  7. ^ "Entrez Gene: TMOD4, Tropomodulin 4 (muscle)".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.