Members of this protein family have been assigned as thiamine transporters by a phylogenomic analysis of families of genes regulated by the THI element, a broadly conserved RNA secondary structure element through which thiamine pyrophosphate (TPP) levels can regulate transcription of many genes related to thiamine transport, salvage, and de novo biosynthesis. Species with this protein always lack the ThiBPQ ABC transporter. In some species (e.g. Streptococcus mutans and Streptococcus pyogenes), yuaJ is the only THI-regulated gene. Evidence from Bacillus cereus indicates thiamine uptake is coupled to proton translocation.[1][2]
| Thia_YuaJ | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Thia_YuaJ | ||||||||
| Pfam | PF09515 | ||||||||
| Pfam clan | CL0315 | ||||||||
| InterPro | IPR012651 | ||||||||
| OPM superfamily | 134 | ||||||||
| OPM protein | 3rlb | ||||||||
| |||||||||
This family includes human solute transporters SLC19A1, SLC19A2 and SLC19A3.
References edit
- ^ Erkens GB, Slotboom DJ (April 2010). "Biochemical characterization of ThiT from Lactococcus lactis: a thiamin transporter with picomolar substrate binding affinity". Biochemistry. 49 (14): 3203–12. doi:10.1021/bi100154r. PMID 20218726.
- ^ Eitinger T, Rodionov DA, Grote M, Schneider E (January 2011). "Canonical and ECF-type ATP-binding cassette importers in prokaryotes: diversity in modular organization and cellular functions". FEMS Microbiology Reviews. 35 (1): 3–67. doi:10.1111/j.1574-6976.2010.00230.x. PMID 20497229.