Testosterone 17b-dehydrogenase (NADP+)

Testosterone 17beta-dehydrogenase (NADP+) (EC 1.1.1.64, 17-ketoreductase, NADP-dependent testosterone-17beta-oxidoreductase, testosterone 17beta-dehydrogenase (NADP)) is an enzyme with systematic name 17beta-hydroxysteroid:NADP+ 17-oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction

Testosterone 17beta-dehydrogenase (NADP+)
Identifiers
EC no.1.1.1.64
CAS no.9028-63-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins
testosterone + NADP+ androstenedione + NADPH + H+

Also oxidizes 3-hydroxyhexobarbital to 3-oxohexobarbital.

References

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  1. ^ Endahl GL, Kochakian CD, Hamm D (October 1960). "Separation of a triphosphopyridine nucleotide-specific from a diphosphopyridine nucleotide-specific 17 beta-hydroxy-(testosterone) dehydrogenase of guinea pig liver". The Journal of Biological Chemistry. 235: 2792–6. PMID 13696735.
  2. ^ Sweat ML, Samuels LT, Lumry R (July 1950). "Preparation and characterization of the enzyme which converts testosterone to androstenedione". The Journal of Biological Chemistry. 185 (1): 75–84. PMID 15436478.
  3. ^ Villee CA, Spencer JM (December 1960). "Some properties of the pyridine nucleotide-specific 17 beta-hydroxy steroid dehydrogenases of guinea pig liver". The Journal of Biological Chemistry. 235: 3615–9. PMID 13781425.
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