Telomere-associated protein RIF1

Telomere-associated protein RIF1 is a protein that in humans is encoded by the RIF1 gene.[5][6][7]

RIF1
Identifiers
AliasesRIF1, replication timing regulatory factor 1
External IDsOMIM: 608952; MGI: 1098622; HomoloGene: 41231; GeneCards: RIF1; OMA:RIF1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001177663
NM_001177664
NM_001177665
NM_018151

NM_175238
NM_001355414
NM_001355415

RefSeq (protein)

NP_001171134
NP_001171135
NP_001171136
NP_060621

NP_780447
NP_001342343
NP_001342344

Location (UCSC)Chr 2: 151.41 – 151.51 MbChr 2: 51.96 – 52.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RIF1 and RIF2 cap the chromosome ends (telomeres) in yeast.[8] In higher eukaryotes, Rif1 is involved in DNA damage response, organisation of chromatin architecture and the regulation of replication timing. RIF1 has been shown to bind to RNA in the nucleus.[9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000080345Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036202Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Silverman J, Takai H, Buonomo SB, Eisenhaber F, de Lange T (September 2004). "Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint". Genes & Development. 18 (17): 2108–19. doi:10.1101/gad.1216004. PMC 515289. PMID 15342490.
  6. ^ Adams IR, McLaren A (April 2004). "Identification and characterisation of mRif1: a mouse telomere-associated protein highly expressed in germ cells and embryo-derived pluripotent stem cells". Developmental Dynamics. 229 (4): 733–44. doi:10.1002/dvdy.10471. PMID 15042697. S2CID 22138565.
  7. ^ "Entrez Gene: RIF1 RAP1 interacting factor homolog (yeast)".
  8. ^ Ribeyre C, Shore D (2012). "Anticheckpoint pathways at telomeres in yeast". Nature Structural & Molecular Biology. 19 (3): 307–13. doi:10.1038/nsmb.2225. PMID 22343724. S2CID 10636976.
  9. ^ Conrad T, Albrecht AS, de Melo Costa VR, Sauer S, Meierhofer D, Ørom UA (2016-01-01). "Serial interactome capture of the human cell nucleus". Nature Communications. 7: 11212. Bibcode:2016NatCo...711212C. doi:10.1038/ncomms11212. PMC 4822031. PMID 27040163.

Further reading

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